3,5-dihydroxyphenyl decanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 3,5-dihydroxyphenyl decanoate
• 英文别名: Decanoic acid 3,5-dihydroxyphenyl ester；(3,5-dihydroxyphenyl) decanoate
• 化学式: C₁₆H₂₄O₄
• 分子量: 280.364
• InChiKey: KRVWPDOYIOBFEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  间苯三酚 、 壬酸 在 N,N'-二环己基碳二亚胺 作用下， 生成 3,5-dihydroxyphenyl decanoate
  参考文献：
  名称：

  Inhibitory effects of cardols and related compounds on superoxide anion generation by xanthine oxidase

  摘要：

  5-Pentadecatrienylresorcinol, isolated from cashew nuts and commonly known as cardol (C-15:3), prevented the generation of superoxide radicals catalysed by xanthine oxidase without the inhibition of uric acid formation. The inhibition kinetics did not follow the Michelis-Menten equation, but instead followed the Hill equation. Cardol (C-10:0) also inhibited superoxide anion generation, but resorcinol and cardol (C-5:0) did not inhibit superoxide anion generation. The related compounds 3,5-dihydroxyphenyl alkanoates and alkyl 2,4-dihydroxybenzoates, had more than a C9 chain, cooperatively inhibited but alkyl 3,5-dihydroxybenzoates, regardless of their alkyl chain length, did not inhibit the superoxide anion generation. These results suggested that specific inhibitors for superoxide anion generation catalysed by xanthine oxidase consisted of an electron-rich resorcinol group and an alkyl chain having longer than C9 chain. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.foodchem.2014.06.021

文献信息

• Rational design of antimicrobial agents: antifungal activity of alk(en)yl dihydroxybenzoates and dihydroxyphenyl alkanoates
  作者：Ken-ichi Nihei、Atsuko Nihei、Isao Kubo

  DOI：10.1016/j.bmcl.2003.08.057

  日期：2003.11

  similar antifungal activity against Saccharomyces cerevisiae. Their nonyl derivatives exhibit the most potent antifungal activity against this yeast with the minimum fungicidal concentration (MFC) in the range between 12.5 and 50 microg/mL. In addition, various 3,4-dihydroxybenzoates, possessing different side chains, namely unsaturated, branched and alicyclic were synthesized and their activity was compared

  每个3,4-和3,5-二羟基苯甲酸烷基酯和3,4-和3,5-二羟基苯基链烷酸烷基酯的同源系列（C3-C14）对啤酒酵母具有相似的抗真菌活性。它们的壬基衍生物对这种酵母表现出最有效的抗真菌活性，其最小杀真菌浓度（MFC）在12.5至50微克/毫升之间。此外，合成了具有不同侧链的各种3,4-二羟基苯甲酸酯，即不饱和，支链和脂环族，并比较了它们的活性。
• METHOD AND SYSTEM FOR EFFECTING CHANGES IN PIGMENTED TISSUE
  申请人：Moazed Kambiz Thomas

  公开号：US20110280909A1

  公开（公告）日：2011-11-17

  Methods and systems are described for a rapid and sustainable change in the pigment melanin content of melanocytes of the iris stroma, thereby to change the color of the eye. Also described are nanoparticle compositions for lightening the pigmented tissues or treating a pigmented tissue related disease.

  描述了一种快速和可持续改变虹膜基质黑色素含量的黑色素细胞的方法和系统，从而改变眼睛的颜色。还描述了用于淡化有色组织或治疗有色组织相关疾病的纳米颗粒组合物。
• Method and system for effecting changes in pigmented tissue
  申请人：Moazed Kambiz Thomas

  公开号：US20120207809A1

  公开（公告）日：2012-08-16

  Methods and systems are described for a rapid and sustainable change in the pigment melanin content of melanocytes of the iris stroma, thereby to change the color of the eye. Also described are compositions for lightening or darkening the pigmented tissues or treating a pigmented tissue disease.

  本文描述了一种快速和可持续改变虹膜基质黑素细胞中黑色素含量的方法和系统，从而改变眼睛的颜色。还描述了用于使色素组织变浅或变深或治疗色素组织疾病的组合物。
• Method for producing polyphenol compounds
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)

  公开号：US10179921B2

  公开（公告）日：2019-01-15

  The present invention relates to a method for producing polyphenol compounds, i.e. phloroglucinol or one of its derivatives, with a polyketide synthase of type III (PKSIII) from a brown marine alga. The invention also relates to recombinant nucleic acids coding for a polyketide synthase of type III (PKSIII) from the brown alga Ectocarpus siliculosus (E. siliculosus), to recombinant vectors comprising these nucleic acids, as well as to host cells comprising these vectors. Finally, the invention relates to a method for preparing of various compounds by means of polyphenol compounds produced according to the aforementioned method.

  本发明涉及一种利用来自褐海藻的Ⅲ型多酮苷合成酶（PKSⅢ）生产多酚化合物（即氯葡萄糖醇或其衍生物之一）的方法。本发明还涉及编码来自棕色海藻硅藻（Ectocarpus siliculosus）的 III 型多酮苷合成酶（PKSIII）的重组核酸、包含这些核酸的重组载体以及包含这些载体的宿主细胞。最后，本发明涉及一种利用按上述方法生产的多酚化合物制备各种化合物的方法。
• UTILISATION DE " POLYKETIDE SYNTHASES " DE TYPE III (PKS III) RECOMBINANTES D'ALGUES BRUNES MARINES
  申请人：Université Pierre et Marie Curie (Paris 6)

  公开号：EP2761005A1

  公开（公告）日：2014-08-06