2-(1-hydroxy-1-phenyl-2-oxopropyl)cyclopentanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(1-hydroxy-1-phenyl-2-oxopropyl)cyclopentanone
• 英文别名: 2-(1-Hydroxy-2-oxo-1-phenylpropyl)cyclopentan-1-one；2-(1-hydroxy-2-oxo-1-phenylpropyl)cyclopentan-1-one
• 化学式: C₁₄H₁₆O₃
• 分子量: 232.279
• InChiKey: BTEOJNCJXQAFIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  环戊酮 、 1-苯基-1,2-丙二酮 在 L-脯氨酸 作用下， 以 二甲基亚砜 为溶剂， 反应 72.0h， 以27%的产率得到2-(1-hydroxy-1-phenyl-2-oxopropyl)cyclopentanone
  参考文献：
  名称：

  Asymmetric direct aldol reaction of 1,2-diketones and ketones mediated by proline derivatives

  摘要：

  The direct aldol reaction of 1,2-diketones and ketones mediated by proline derivatives yields the corresponding 2-hydroxy 1,4-diketones in high regioselectivity, diastereoselectivity and good enantioselectivity. This reaction provides an easy access to optically active tertiary alcohols, which are flanked by two carbonyl groups for further elaborations. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.03.085

文献信息

• Asymmetric direct aldol reaction of 1,2-diketones and ketones mediated by proline derivatives
  作者：Sampak Samanta、Cong-Gui Zhao

  DOI：10.1016/j.tetlet.2006.03.085

  日期：2006.5

  The direct aldol reaction of 1,2-diketones and ketones mediated by proline derivatives yields the corresponding 2-hydroxy 1,4-diketones in high regioselectivity, diastereoselectivity and good enantioselectivity. This reaction provides an easy access to optically active tertiary alcohols, which are flanked by two carbonyl groups for further elaborations. (c) 2006 Elsevier Ltd. All rights reserved.