N^α-[(butyloxycarbonyl)-N^ε-(2-chlorobenzyloxycarbonyl)-L-lysyl]-L-aspartic acid β-cyclohexyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N^α-[(butyloxycarbonyl)-N^ε-(2-chlorobenzyloxycarbonyl)-L-lysyl]-L-aspartic acid β-cyclohexyl ester
• 英文别名: Boc-Lys(Cbz(2-Cl))(Cbz(2-Cl))-Asp(OcHex)(OcHex)-OH；(2S)-2-[[(2S)-6-[(2-chlorophenyl)methoxycarbonylamino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoyl]amino]-4-cyclohexyloxy-4-oxobutanoic acid
• 化学式: C₂₉H₄₂ClN₃O₉
• 分子量: 612.12
• InChiKey: TXFHERLTDVWCJA-GOTSBHOMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  42
• 可旋转键数：
  18
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  169
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  N-叔丁氧羰基-N'-甲苯磺酰基-L-精氨酸 、 6-methyl-5-[(tert-butyloxycarbonyl)amino]-4-oxo-2-benzylheptanoic acid 、 N^α-[(butyloxycarbonyl)-N^ε-(2-chlorobenzyloxycarbonyl)-L-lysyl]-L-aspartic acid β-cyclohexyl ester 生成 Arg-Lys-Asp-Val(k)Phe
  参考文献：
  名称：

  Stabilized Analogs of Thymopentin. 1. 4,5-Ketomethylene Pseudopeptides

  摘要：

  The pentapeptide, thymopentin (Arg(1)-Lys(2)-Asp(3)-Val(4)-Tyr(5)) is known for its activity as an immunomodulating drug, but with limited half-life in plasma. In this first paper of a series of three studies, the synthesis of analogs stabilized at the peptide bond between the C-terminal amino acids via insertion of a ketomethylene moiety is described. N-Blocked pseudopeptides containing Val(k)Phe, Ala(k)Phe, and Val(k)Val units were prepared and attached to chloromethyl Merrifield resin via the carboxy terminal. Removal of the N-BOC group by trifluoroacetic acid was followed by sequential coupling with N-BOC dipeptides of aspartic acid to yield resin-bound N-BOC pseudotetrapeptides. Removal of N-BOC and coupling with N-BOC-r-N-tosylarginine followed by total cleavage of blocking groups and resin by HF afforded the target pseudopentapeptides. The analogs were found to compete favorably with thymopentin for binding to CEM cells, but binding was reduced by about 20-30% on average. All analogs showed significant enhancement of half-life versus thymopentin in mouse serum, but most showed only modest improvement in human serum. Insertion of proline or norleucine at position 2 in the chain caused a substantial increase in half-life (3-4-fold), while N-methylnorleucine conferred complete stability in the analogs.

  DOI：

  10.1021/jm950803a
• 作为产物：
  描述：

  N-叔丁氧羰基-N'-(2-氯苄氧羰基)-L-赖氨酸 在 N-甲基吗啉 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 生成 N^α-[(butyloxycarbonyl)-N^ε-(2-chlorobenzyloxycarbonyl)-L-lysyl]-L-aspartic acid β-cyclohexyl ester
  参考文献：
  名称：

  Stabilized Analogs of Thymopentin. 1. 4,5-Ketomethylene Pseudopeptides

  摘要：

  The pentapeptide, thymopentin (Arg(1)-Lys(2)-Asp(3)-Val(4)-Tyr(5)) is known for its activity as an immunomodulating drug, but with limited half-life in plasma. In this first paper of a series of three studies, the synthesis of analogs stabilized at the peptide bond between the C-terminal amino acids via insertion of a ketomethylene moiety is described. N-Blocked pseudopeptides containing Val(k)Phe, Ala(k)Phe, and Val(k)Val units were prepared and attached to chloromethyl Merrifield resin via the carboxy terminal. Removal of the N-BOC group by trifluoroacetic acid was followed by sequential coupling with N-BOC dipeptides of aspartic acid to yield resin-bound N-BOC pseudotetrapeptides. Removal of N-BOC and coupling with N-BOC-r-N-tosylarginine followed by total cleavage of blocking groups and resin by HF afforded the target pseudopentapeptides. The analogs were found to compete favorably with thymopentin for binding to CEM cells, but binding was reduced by about 20-30% on average. All analogs showed significant enhancement of half-life versus thymopentin in mouse serum, but most showed only modest improvement in human serum. Insertion of proline or norleucine at position 2 in the chain caused a substantial increase in half-life (3-4-fold), while N-methylnorleucine conferred complete stability in the analogs.

  DOI：

  10.1021/jm950803a

文献信息

• Stabilized Analogs of Thymopentin. 1. 4,5-Ketomethylene Pseudopeptides
  作者：Joseph I. DeGraw、Ronald G. Almquist、Charles K. Hiebert、William T. Colwell、Jac Crase、Takeshi Hayano、Amrit K. Judd、Linda Dousman、R. Lane Smith、William R. Waud、Itsuo Uchida

  DOI：10.1021/jm950803a

  日期：1997.7.1

  The pentapeptide, thymopentin (Arg(1)-Lys(2)-Asp(3)-Val(4)-Tyr(5)) is known for its activity as an immunomodulating drug, but with limited half-life in plasma. In this first paper of a series of three studies, the synthesis of analogs stabilized at the peptide bond between the C-terminal amino acids via insertion of a ketomethylene moiety is described. N-Blocked pseudopeptides containing Val(k)Phe, Ala(k)Phe, and Val(k)Val units were prepared and attached to chloromethyl Merrifield resin via the carboxy terminal. Removal of the N-BOC group by trifluoroacetic acid was followed by sequential coupling with N-BOC dipeptides of aspartic acid to yield resin-bound N-BOC pseudotetrapeptides. Removal of N-BOC and coupling with N-BOC-r-N-tosylarginine followed by total cleavage of blocking groups and resin by HF afforded the target pseudopentapeptides. The analogs were found to compete favorably with thymopentin for binding to CEM cells, but binding was reduced by about 20-30% on average. All analogs showed significant enhancement of half-life versus thymopentin in mouse serum, but most showed only modest improvement in human serum. Insertion of proline or norleucine at position 2 in the chain caused a substantial increase in half-life (3-4-fold), while N-methylnorleucine conferred complete stability in the analogs.