cis-2-butoxy-1-phenyl-cyclopropane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: cis-2-butoxy-1-phenyl-cyclopropane
• 英文别名: [(1R,2R)-2-butoxycyclopropyl]benzene
• 化学式: C₁₃H₁₈O
• 分子量: 190.285
• InChiKey: SADUBIQVPMKKEU-CHWSQXEVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  乙烯基正丁醚 、 benzylidene(pentacarbonyl)tungsten 生成 cis-2-butoxy-1-phenyl-cyclopropane
  参考文献：
  名称：

  DOYLE, M. P.;GRIFFIN, J. H.;BAGHERI, V.;DOROW, R. L., ORGANOMETALLICS, 1984, 3, N 1, 53-61

  摘要：

  DOI：

文献信息

• CYCLOPROPYLBORONIC COMPOUNDS, METHOD FOR PREPARING SAME AND USE THEREOF
  申请人：DIVERCHIM

  公开号：US20150329566A1

  公开（公告）日：2015-11-19

  Cyclopropylboronic compounds, the preparation process thereof and the use thereof.

  环丙基硼化合物，其制备方法及用途。
• Catalytic Cyclopropanation of Alkenes Using Diazo Compounds Generated in Situ. A Novel Route to 2-Arylcyclopropylamines
  作者：Varinder K. Aggarwal、Javier de Vicente、Roger V. Bonnert

  DOI：10.1021/ol0164177

  日期：2001.8.1

  [reaction: see text]. A user-friendly, one-pot process for catalytic cyclopropanation of alkenes from tosylhydrazones is described. The cyclopropanation of N-vinylphthalimide provides a new route to 2-arylcyclopropylamines, and this is exemplified in the efficient synthesis of the HIV-1 reverse transcriptase inhibitor 6.

  [反应：请参见文字]。本文描述了一种用户友好的一锅法，用于从甲苯磺酰nes酮进行烯烃的催化环丙烷化。N-乙烯基邻苯二甲酰亚胺的环丙烷化为2-芳基环丙胺提供了一条新途径，这在HIV-1逆转录酶抑制剂6的有效合成中得到了证明。
• Substituent Effects and the Mechanism of Gold to Alkene Benzylidene Transfer Employing a Gold Sulfonium Benzylide Complex
  作者：Mitch Rivers、Robert G. Carden、Ross A. Widenhoefer

  DOI：10.1021/acs.organomet.2c00097

  日期：2022.5.9

  sulfonium benzylide complex [(P)AuCHPh(SPh2)]+ B [3,5-CF3C6H3]4}− [P = P (t-Bu)2o-biphenyl; 1] at room temperature via the cationic two-coordinate gold benzylidene complex [(P)AuCHPh]+ (I) to form phenyclyclopropanes. The reactivity of p-substituted vinyl arenes toward I decreased with the decreasing electron donor ability of the vinyl arene (ρ = −1.49 ± 0.15), and the reactivity of aliphatic alkenes

  脂肪族和芳香族烯烃与金锍苄基络合物 [( P )AuCHPh(SPh 2 )] + B [3,5-CF 3 C 6 H 3 ] 4 } - [ P = P ( t -Bu ) 2邻联苯；1 ] 在室温下通过阳离子双配位金亚苄基配合物[( P )AuCHPh] + ( I ) 生成苯环丙烷。对位取代乙烯基芳烃对I的反应性随着乙烯基芳烃的电子供体能力降低（ρ = -1.49 ± 0.15），脂肪族烯烃对I的反应性在很大程度上取决于连接到更多取代烯烃末端的烷基数量。亚苄基向顺式和反式-β-甲基苯乙烯的转移发生，烯烃构型完全保留。亚苄基转移到乙烯基芳烃导致顺式的主要形成-环丙烷（dr = 4.1:1 至 13.9:1），而亚苄基转移至脂肪族烯烃的选择性通常较低（dr = 1.3:1 至 5.1:1）。我们所有的实验观察结果都与协调的、异步的、亲电的亚苄基转移机制一致。亚苄基转移的非对映选择性是在
• Olefin cyclopropanation with aryl diazocompounds upon catalysis by a dirhodium(II) complex
  作者：Mirella Verdecchia、Cristina Tubaro、Andrea Biffis

  DOI：10.1016/j.tetlet.2011.01.002

  日期：2011.3

  A dirhodium(II) complex with N-perfluorooctylsulfonylprolinate ligands is found to catalyze the cyclopropanation of olefins with simple aryl diazomethanes. In contrast to previously reported dirhodium(II) catalysts, the present complex works well not only with very electron-rich olefins such as enol ethers, but also with styrenes. Consequently, the present catalyst allows to prepare functionalized diarylcyclopropanes in moderate yields with good diastereoselectivity for the cis product, whereas the enantioselectivity of the reaction appears negligible. (C) 2011 Elsevier Ltd. All rights reserved.
• COMPOSES CYCLOPROPYLBORONIQUES, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION
  申请人：Diverchim

  公开号：EP2931708B1

  公开（公告）日：2017-05-10