3-[2-(4-amino-1-piperidinyl)ethyl]indole monohydrate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-[2-(4-amino-1-piperidinyl)ethyl]indole monohydrate
• 英文别名: 4-Amino-1-[2-(3-indolyl)ethyl]piperidine hydrate；3-[2-(4-Amino-1-piperidyl) ethyl]indole hydrate；3-[2-(4-aminopiperidyl)ethyl]indole, hydrate；3-[2-(4-aminopiperidyl)ethyl]indole hydrate；1-[2-(1H-indol-3-yl)ethyl]piperidin-4-amine;hydrate
• 化学式: C₁₅H₂₁N₃*H₂O
• 分子量: 261.367
• InChiKey: ZBRYLZUNTAQVSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.31
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  46
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-[2-(4-amino-1-piperidinyl)ethyl]indole monohydrate 、 3,4-二氯苯异氰酸酯 在 1-(3,4-dichloro-phenyl)-3-[1-(2-indol-3-yl-ethyl)-piperidin-4-yl]-urea 作用下， 以gave the crude title compound (2.03 g.) from which a pure hydrochloride (1.70 g., m.p. 258.4°, dec.)的产率得到1-(3,4-dichloro-phenyl)-3-[1-(2-indol-3-yl-ethyl)-piperidin-4-yl]-urea
  参考文献：
  名称：

  1-[(3-Indolyl)-alkyl]-piperidyl ureas and hypotensive compositions

  摘要：

  本发明提供了一般式I的化合物及其药学上可接受的酸加成物和季铵盐，其中R代表氢或低碳基，R.sup.1代表氢或低碳基，R.sup.2代表氢或低碳基，R.sup.3代表氢，卤素，低烷氧基，羟基或低碳基，R.sup.4代表氢，低碳基，5至7个碳原子的环烷基，噻吩基，呋喃基，苯基；苯单取代或双取代的卤素，低烷基，低烷氧基，羟基或三氟甲基；或苯甲酰基，卤苯甲酰基，6至8个碳原子的环烷基酰基，或噻吩基酰基，A代表1至5个碳原子的烷基，单或双酮基或羟基烷基基团，X为氧或硫。这些化合物表现出对心血管系统的作用，特别是降压和/或抗高血压活性。

  公开号：

  US04177279A1

文献信息

• Ureidopiperidino-ketoalkyl indoles
  申请人：John Wyeth & Brother Limited

  公开号：US04061641A1

  公开（公告）日：1977-12-06

  The invention provides compounds of general formula I ##STR1## and pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein R represents hydrogen or lower alkyl, R.sup.1 represents hydrogen or lower alkyl, R.sup.2 represents hydrogen or lower alkyl, R.sup.3 represents hydrogen, halogen, lower alkoxy, hydroxy, or lower alkyl, R.sup.4 represents hydrogen, lower alkyl, cycloalkyl of 5 to 7 carbon atoms, thienyl, furyl, phenyl; phenyl mono- or disubstituted by halogen, lower alkyl, lower alkoxy, hydroxy or trifluoromethyl; or benzoyl, halobenzoyl, lower alkanoyl, cycloalkanoyl of 6 to 8 carbon atoms, or thienoyl, A represents an alkylene, mono- or diketo- or hydroxy-alkylene radical having from 1 to 5 carbon atoms and X is oxygen or sulphur. The compounds exhibit action on the cardiovascular system particularly hypotensive and/or anti-hypertensive activity.

  本发明提供一般式I的化合物及其药学上可接受的酸加合物和季铵盐，其中R代表氢或较低的烷基，R.sup.1代表氢或较低的烷基，R.sup.2代表氢或较低的烷基，R.sup.3代表氢、卤素、较低的烷氧基、羟基或较低的烷基，R.sup.4代表氢、较低的烷基、5至7个碳原子的环烷基、噻吩基、呋喃基、苯基；苯基单取代或双取代的卤素、较低的烷基、较低的烷氧基、羟基或三氟甲基；或苯甲酰基、卤代苯甲酰基、较低的烷酰基、6至8个碳原子的环烷酰基或噻吩酰基，A代表含有1至5个碳原子的烷基、单或双酮基或羟基烷基基团，X为氧或硫。这些化合物表现出对心血管系统的作用，特别是降低血压和/或抗高血压活性。
• Piperidyl-glycylamide derivatives
  申请人：John Wyeth & Brother Limited

  公开号：US04045566A1

  公开（公告）日：1977-08-30

  This invention relates to compounds having the general formula: ##STR1## wherein W represents a phenyl or indolyl radical, either of which radicals may be unsubstituted or substituted by halogen, lower alkyl, lower alkoxy or hydroxy; A represents a lower alkylene radical an oxo lower alkylene radical or a hydroxy lower alkylene radical; R represents a phenyl radical optionally substituted by halogen, lower alkyl, lower alkoxy or hydroxy, or a cycloalkyl radical of 5 to 7 carbon atoms; R.sup.1 represents hydrogen or a lower alkyl radical or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof; which possess hypotensive activity.

  本发明涉及具有以下一般式的化合物：##STR1##其中W代表苯基或吲哚基，这两种基团可以是未取代的或被卤素、低烷基、低烷氧基或羟基取代的；A代表低烷基烷基、氧代低烷基烷基或羟基低烷基烷基；R代表苯基，可选地被卤素、低烷基、低烷氧基或羟基取代，或者是由5到7个碳原子的环烷基；R.sup.1代表氢或低烷基基团或其药学上可接受的酸加合物或季铵盐；这些化合物具有降压作用。
• Sulphonamidopiperidyl derivatives
  申请人：John Wyeth & Brother Limited

  公开号：US04034098A1

  公开（公告）日：1977-07-05

  This invention relates to compounds having the general formula: ##STR1## WHEREIN W represents a phenyl or indolyl radical, either of which radicals may be unsubstituted or substituted by halogen, lower alkyl, lower alkoxy or hydroxy. A represents a lower alkylene radical, an oxo lower alkylene radical or a hydroxy lower alkylene radical; R represents a phenyl radical optionally substituted by halogen, lower alkyl, lower alkoxy or hydroxy, a cycloalkyl radical of 5 to 7 carbon atoms or a lower alkyl radical; R.sup.1 represents hydrogen or a lower alkyl radical or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof; which possess hypotensive activity.

  本发明涉及具有以下通式的化合物：##STR1## 其中W代表苯基或吲哚基，这两种基团可以是未取代的或取代为卤素，较低的烷基，较低的烷氧基或羟基。A代表较低的烷基烯基基团，氧代较低的烷基烯基基团或羟基较低的烷基烯基基团；R代表苯基基团，该基团可以选择性地被卤素，较低的烷基，较低的烷氧基或羟基取代，环烷基基团，其碳原子数为5到7，或较低的烷基基团；R.sup.1代表氢或较低的烷基基团，或其药学上可接受的酸加合物或季铵盐；这些化合物具有降压活性。
• Hypotensive sulphonamidopiperidyl indoles
  申请人：John Wyeth & Brother Ltd.

  公开号：US04131680A1

  公开（公告）日：1978-12-26

  This invention relates to compounds having the general formula: ##STR1## WHEREIN W represents a phenyl or indolyl radical, either of which radicals may be unsubstituted or substituted by halogen, lower alkyl, lower alkoxy or hydroxy. A represents a lower alkylene radical, an oxo lower alkylene radical or a hydroxy lower alkylene radical; R represents a phenyl radical optionally substituted by halogen, lower alkyl, lower alkoxy or hydroxy, a cycloalkyl radical of 5 to 7 carbon atoms or a lower alkyl radical; R.sup.1 represents hydrogen or a lower alkyl radical or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof; which possess hypotensive activity.

  本发明涉及具有以下一般式的化合物：##STR1## 其中W代表苯基或吲哚基，这两种基团可以是未取代的或被卤素、低烷基、低烷氧基或羟基取代的；A代表低烷基烷基、氧代低烷基烷基或羟基低烷基烷基；R代表苯基，可选地被卤素、低烷基、低烷氧基或羟基取代，5到7个碳原子的环烷基或低烷基；R.sup.1代表氢或低烷基基团或其药学上可接受的酸盐或季铵盐；这些化合物具有降压活性。
• US4131680A
  申请人：——

  公开号：US4131680A

  公开（公告）日：1978-12-26