2-(tert-butoxycarbonyl)-4-ethoxycarbonyl-3-methylpyrrole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-(tert-butoxycarbonyl)-4-ethoxycarbonyl-3-methylpyrrole
• 英文别名: 2-O-tert-butyl 4-O-ethyl 3-methyl-1H-pyrrole-2,4-dicarboxylate
• 化学式: C₁₃H₁₉NO₄
• 分子量: 253.298
• InChiKey: OTGTXLRGDJDGGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  68.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-丁炔酸乙酯 、 异氰基乙酸叔丁酯 在 copper(I) oxide 、 1,10-菲罗啉 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.5h， 以71%的产率得到2-(tert-butoxycarbonyl)-4-ethoxycarbonyl-3-methylpyrrole
  参考文献：
  名称：

  Copper- or Phosphine-Catalyzed Reaction of Alkynes with Isocyanides. Regioselective Synthesis of Substituted Pyrroles Controlled by the Catalyst

  摘要：

  The copper-catalyzed reaction of isocyanides (CNCH(2)EWG(1)) 1 with electron-deficient alkynes (RC equivalent to CEWG(2)) 2 gave the 2,4-di-EWG-substituted pyrroles 3 selectively, whereas the phosphine-catalyzed reaction of 1 with 2 afforded the 2,3-di-EWG-subsituted pyrroles 4. Accordingly, regioselective synthesis of substituted pyrroles has been achieved by merely choosing the catalyst.

  DOI：

  10.1021/ja051875m

文献信息

• Copper- or Phosphine-Catalyzed Reaction of Alkynes with Isocyanides. Regioselective Synthesis of Substituted Pyrroles Controlled by the Catalyst
  作者：Shin Kamijo、Chikashi Kanazawa、Yoshinori Yamamoto

  DOI：10.1021/ja051875m

  日期：2005.6.1

  The copper-catalyzed reaction of isocyanides (CNCH(2)EWG(1)) 1 with electron-deficient alkynes (RC equivalent to CEWG(2)) 2 gave the 2,4-di-EWG-substituted pyrroles 3 selectively, whereas the phosphine-catalyzed reaction of 1 with 2 afforded the 2,3-di-EWG-subsituted pyrroles 4. Accordingly, regioselective synthesis of substituted pyrroles has been achieved by merely choosing the catalyst.