S-(3-phenylpropyl) n-hexyldithiocarbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: S-(3-phenylpropyl) n-hexyldithiocarbamate
• 英文别名: 3-phenylpropyl N-hexylcarbamodithioate
• 化学式: C₁₆H₂₅NS₂
• 分子量: 295.513
• InChiKey: LNMXSJPCPVYQCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  69.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二硫化碳 、 正己胺 、 1-氯-3-苯基丙烷 在 苄基三甲基氢氧化铵 作用下， 以 二甲基亚砜 为溶剂， 反应 4.33h， 以92%的产率得到S-(3-phenylpropyl) n-hexyldithiocarbamate
  参考文献：
  名称：

  Triton-B Catalyzed Efficient One-Pot Synthesis of Dithiocarbamate Esters

  摘要：

  A novel process for the one-step chemoselective conversion of alkyl halides into dithiocarbamates as protected amines was developed using benzyltrimethylammonium hydroxide (Triton-B) in presence of carbon disulfide. Thus, dithiocarbamates of different amines were prepared in very good to excellent yields. This protocol is mild, chemoselective, and efficient compared to other methods.

  DOI：

  10.1007/s00706-006-0438-8

文献信息

• An efficient, one-pot, synthesis of dithiocarbamates from the corresponding alcohols using Mitsunobu’s reagent
  作者：Devdutt Chaturvedi、Suprabhat Ray

  DOI：10.1016/j.tetlet.2005.12.079

  日期：2006.2

  A Mitsunobu-based protocol has been developed for the synthesis of dithiocarbamates from the corresponding alcohols using carbon disulfide and amines in good to excellent yields. This protocol is mild, chemoselective and efficient compared to other reported methods.

  已经开发出一种基于Mitsunobu的方案，该方案可以使用二硫化碳和胺从相应的醇合成二硫代氨基甲酸酯，且收率良好至极佳。与其他报道的方法相比，该方案是温和的，化学选择性的和有效的。
• A High Yielding, One-Pot, Triton-B Catalyzed Synthesis of Dithiocarbamates Using Alcoholic Tosylates
  作者：Devdutt Chaturvedi、Suprabhat Ray

  DOI：10.1007/s00706-005-0460-2

  日期：2006.4

  A novel process for the one-step chemoselective conversion of alcoholic tosylates into. dithiocarbamates as protected amines was developed using benzyltlimethylammoniumhydroxide (Triton-B) in presence of carbon disulfide. Thus, dithiocarbamates of different amines were prepared in very good to excellent yields. This protocol is mild, chemoselective, and efficient compared to other reported methods.
• Triton-B Catalyzed Efficient One-Pot Synthesis of Dithiocarbamate Esters
  作者：Devdutt Chaturvedi、Suprabhat Ray

  DOI：10.1007/s00706-006-0438-8

  日期：2006.3

  A novel process for the one-step chemoselective conversion of alkyl halides into dithiocarbamates as protected amines was developed using benzyltrimethylammonium hydroxide (Triton-B) in presence of carbon disulfide. Thus, dithiocarbamates of different amines were prepared in very good to excellent yields. This protocol is mild, chemoselective, and efficient compared to other methods.