3,6-di-(p-tolyl)-1,2-difluorobenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,6-di-(p-tolyl)-1,2-difluorobenzene
• 英文别名: 2,3-Difluoro-1,4-bis(4-methylphenyl)benzene
• 化学式: C₂₀H₁₆F₂
• 分子量: 294.344
• InChiKey: HXEBRPJFHIFBFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对溴甲苯 、 1,2-二氟苯 在 palladium diacetate di-tert-butyl(methyl)phosphonium tetrafluoroborate salt 、 potassium carbonate 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 以29%的产率得到1,2-difluoro-3-(4-methylphenyl)benzene
  参考文献：
  名称：

  Catalytic Intermolecular Direct Arylation of Perfluorobenzenes

  摘要：

  Penta-, tetra-, tri-, and difluorobenzenes undergo direct arylation with a wide range of arylhalides in high yield. Inverse reactivity is observed compared to the common electrophilic aromatic substitution pathway since electron-deficient, C-H acidic arenes react preferentially. Computational studies indicate that C-H bond cleavage occurs via a concerted carbon-palladium and carbon-hydrogen bond cleaving event involving a carbonate or a bromide ligand. The reactions are rapid, require only a slight excess of the perfluoroarene reagent, and utilize commercially available, air-stable catalyst precursors.

  DOI：

  10.1021/ja062509l

文献信息

• POLYMERIZABLE COMPOUNDS
  申请人：Bremer Matthias

  公开号：US20090141215A1

  公开（公告）日：2009-06-04

  The present invention relates to novel polymerizable compounds, to processes and intermediates for the preparation thereof, and to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, especially in LC displays of the PS (polymer-stabilized) and PSA (polymer-sustained alignment) type.

  本发明涉及新型可聚合化合物，以及用于制备其的过程和中间体，以及其在光学、电光和电子方面的用途，特别是在液晶（LC）介质和LC显示器中的应用，尤其是在PS（聚合物稳定）和PSA（聚合物维持对齐）类型的LC显示器中的应用。
• LIQUID-CRYSTALLINE MEDIUM AND LIQUID-CRYSTAL DISPLAY COMPRISING THE SAME AND COMPOUNDS
  申请人：Merck Patent GmbH

  公开号：US20210207029A1

  公开（公告）日：2021-07-08

  A liquid-crystalline medium having a nematic phase containing one or more compounds of formula D the use thereof in an electro-optical display, particularly in an active-matrix display based on the IPS or FFS effect, displays of this type which contain a liquid-crystalline medium of this type and the use of the compounds of formula D for improvement of the contrast and/or response times of a liquid-crystalline medium which contain one or more additional mesogenic compounds, as well as certain compounds of formula D.

  一种具有向列相的液晶介质，其中包含一个或多个化合物的化学式D，在电光显示器中的使用，特别是基于IPS或FFS效应的主动矩阵显示器中的使用，这种类型的显示器包含这种类型的液晶介质，并且使用化学式D的化合物来改善包含一个或多个额外向列相化合物的液晶介质的对比度和/或响应时间，以及某些化学式D的化合物。
• [EN] LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY<br/>[FR] MÉLANGE DE CRISTAUX LIQUIDES ET DISPOSITIF D'AFFICHAGE À CRISTAUX LIQUIDES
  申请人：MERCK PATENT GMBH

  公开号：WO2020245084A1

  公开（公告）日：2020-12-10

  The invention relates to a compound of formula (I), wherein R11, R21, A11, A, Z, X11, X21, Y11, Y12, Sp11, Sp21, o and p have one of the meanings as given in claim 1. The invention further relates to method of production of a compound of formula (I), to the use of said compounds in LC media and to LC media comprising one or more compounds of formula (I). Further, the invention relates to a method of production of such LC media, to the use of such media in LC devices, and to LC device comprising a LC medium according to the present invention.The present invention further relates to a process for the fabrication such liquid crystal display and to the use of the liquid crystal mixtures according to the invention for the fabrication of such liquid crystal display.

  该发明涉及一种具有式（I）的化合物，其中R11、R21、A11、A、Z、X11、X21、Y11、Y12、Sp11、Sp21、o和p具有如权利要求1中所述的含义之一。该发明还涉及一种生产式（I）化合物的方法，以及在液晶介质中使用所述化合物和包含一种或多种式（I）化合物的液晶介质。此外，该发明涉及一种生产此类液晶介质的方法，以及在液晶设备中使用此类介质，以及包括根据本发明的液晶介质的液晶设备。本发明还涉及一种制造液晶显示器的方法，以及根据本发明使用液晶混合物制造此类液晶显示器。
• LIQUID CRYSTAL COMPOUNDS OF CYCLOALKYL-CONTAINING DIBENZOFURAN DERIVATIVES, PREPARATION METHOD THEREFOR AND USE THEREOF
  申请人：Shijiazhuang Chengzhi Yonghua Display Material Co., Ltd

  公开号：US20180112132A1

  公开（公告）日：2018-04-26

  Disclosed are liquid crystal compounds of cycloalkyl-containing dibenzofuran derivatives, a preparation method therefor and use thereof. The compounds are as represented by formula I. In the molecular structures of the compounds of formula I provided by the present invention, liquid crystal compounds of cycloalkyl terminal group-containing dibenzofuran derivatives, compared with those having flexible alkyl chains as terminal groups, exhibit better intersolubility, and thus the use of a compound as represented by formula I provided by the present invention can improve the intersolubility of a liquid crystal compound and extend the application range of a liquid crystal mixture, producing an important application value.

  本发明揭示了环烷基含有二苯并呋喃衍生物的液晶化合物，其制备方法和用途。该化合物如公式I所示。在本发明提供的公式I化合物的分子结构中，与具有柔性烷基链作为末端基团的化合物相比，含有环烷基末端基团的二苯并呋喃衍生物的液晶化合物表现出更好的互溶性，因此使用本发明提供的公式I所代表的化合物可以改善液晶化合物的互溶性并扩展液晶混合物的应用范围，产生重要的应用价值。
• COMPOUNDS AND LIQUID-CRYSTALLINE MEDIUM
  申请人：MERCK PATENT GMBH

  公开号：US20180216005A1

  公开（公告）日：2018-08-02

  Compounds of the formula I, and liquid-crystalline media, preferably having a nematic phase and negative dielectric anisotropy, comprising a) one or more compounds of the formula I and one or more compounds selected from b) one or more compounds of formula II and/or c) one or more compounds selected from compounds of formulae III-1 to III-4 and formula B Methods for making and using these liquid-crystalline media in electro-optical displays, particularly in active-matrix displays based on the VA, ECB, PALC, FFS or IPS effect and the displays which contain these media. Methods for stabilizing liquid-crystalline media with compounds of formula I, where the liquid-crystalline media comprise one or more compounds of the formula II and one or more compounds selected from compounds of the formulae III-1 to III-4 and formula B.

  公式I的化合物和液晶介质，最好具有向列相和负介电各向异性，包括a) 一个或多个公式I的化合物和一个或多个选自b) 一个或多个公式II的化合物和/或c) 一个或多个选自公式III-1至III-4和公式B的化合物的液晶介质的方法。制备和使用这些液晶介质的方法在电光显示中，特别是基于VA、ECB、PALC、FFS或IPS效应的主动矩阵显示和包含这些介质的显示器。一种使用公式I的化合物稳定液晶介质的方法，其中液晶介质包括一个或多个公式II的化合物和一个或多个选自公式III-1至III-4和公式B的化合物。