ethyl 3-(1,4-dithiaspiro[4.5]dec-6-yl)propionate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 3-(1,4-dithiaspiro[4.5]dec-6-yl)propionate
• 英文别名: Ethyl 3-(1,4-dithiaspiro[4.5]decan-6-yl)propanoate；ethyl 3-(1,4-dithiaspiro[4.5]decan-6-yl)propanoate
• 化学式: C₁₃H₂₂O₂S₂
• 分子量: 274.448
• InChiKey: QBNMEVVKMPFLSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  76.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl β-(2-ethylene ketal-cyclohexyl)propionate 、 1,2-乙二硫醇 在 In(OSO₂CF₃)3 作用下， 以 二氯甲烷 为溶剂， 反应 4.5h， 以90%的产率得到ethyl 3-(1,4-dithiaspiro[4.5]dec-6-yl)propionate
  参考文献：
  名称：

  Indium triflate: a mild Lewis acid catalyst for thioacetalization and transthioacetalization

  摘要：

  Protection of a variety of carbonyl compounds as thioacetals using indium triflate, a mild Lewis acid catalyst, was achieved at ambient temperature in very good yield. Transthioacetalization of oxyacetals into thioacetals was also achieved in an excellent yield. A mixture of carbonyl compound and its respective oxyacetal was also completely converted into thioacetal in the presence of indium triflate. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00897-9

文献信息

• Indium triflate: a mild Lewis acid catalyst for thioacetalization and transthioacetalization
  作者：Sengodagounder Muthusamy、Srinivasarao Arulananda Babu、Chidambaram Gunanathan

  DOI：10.1016/s0040-4020(02)00897-9

  日期：2002.9

  Protection of a variety of carbonyl compounds as thioacetals using indium triflate, a mild Lewis acid catalyst, was achieved at ambient temperature in very good yield. Transthioacetalization of oxyacetals into thioacetals was also achieved in an excellent yield. A mixture of carbonyl compound and its respective oxyacetal was also completely converted into thioacetal in the presence of indium triflate. (C) 2002 Elsevier Science Ltd. All rights reserved.