Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are z-2-acylamino-3-monosubstituted propenoates.
Combination of thienamycin-type antibiotics with dipeptidase inhibitors
申请人:Merck & Co., Inc.
公开号:US04539208A1
公开(公告)日:1985-09-03
A novel antibacterial drug combination is provided, one component being a fused ring .beta.-lactam, such as thienamycin and its semi-synthetic derivatives, and the other component is a dipeptidase (E.C. 3.4.13.11) inhibitor. The dual-component combination is formulated so that 1 to 3 parts by weight of the .beta.-lactam compound are employed for 30 to 1 parts by weight of the inhibitor compound.
Use of substituted propenoates to prevent nephrotoxicity of certain
申请人:Merck & Co., Inc.
公开号:US04668504A1
公开(公告)日:1987-05-26
Antibiotics to prevent nephrotoxicity.
使用抗生素以预防肾毒性。
Combination of 2-substituted carbapenems with dipeptidase inhibitors
申请人:Merck & Co., Inc.
公开号:US05071843A1
公开(公告)日:1991-12-10
A combination of a carbapenem of the formula: ##STR1## where R is H or CH.sub.3 and R.sup.1 is ##STR2## with a renal dipeptidase inhibitor is disclosed.
Antibacterial compositions comprising a beta-lactam-type compound and a 3-substituted propenoate
申请人:Merck & Co., Inc.
公开号:EP0028778A1
公开(公告)日:1981-05-20
An antibacterial composition comprising (a) cephaloridine and a 3-substituted propenoate of either of the formula
wherein e.g. R2 and R3 are hydrocarbon radicals; a terminal hydrogen in R3 can be replaced by several groups; R' is hydrogen or C1-C6 alkyl or dialkylaminoalkyl, n is 3 to 5 and Y is heterocyclic or phenyl optionally substituted with hydroxyl, oxo, carboxyl, or methyl or (b) thienamycin, N-guanyl or N-formimidoyl thienamycin and a compound of formula II. The propenoate compounds prevent nephrotoxicity of the antibiotics. The antibiotic to propenoate weight ratio is from about 1 to 0.1-3.