N-iso-butyl-3-methylmaleimide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-iso-butyl-3-methylmaleimide
• 英文别名: 3-Methyl-1-(2-methylpropyl)pyrrole-2,5-dione
• 化学式: C₉H₁₃NO₂
• 分子量: 167.208
• InChiKey: JRZCAEFRXXFWLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  柠康酸酐 、 异丁胺 在 溶剂黄146 作用下， 以70.8%的产率得到N-iso-butyl-3-methylmaleimide
  参考文献：
  名称：

  一系列马来酰亚胺的抗Leishmanial和细胞毒活性：合成，生物学评估和结构活性关系。

  摘要：

  在本研究中，已经合成了45种马来酰亚胺，并评估了其对体外杜氏乳酸杆菌的抗利什曼活性和对THP1细胞的细胞毒性。所有化合物均表现出明显的抗利什曼活性。在所测试的化合物中，有10种具有比标准药物两性霉素B更高的抗利什曼活性的马来酰亚胺，和32种具有比标准药物戊tam具有更好的抗利什曼活性的马来酰亚胺，尤其是化合物16（IC50 <0.0128μg/ mL）和42（IC50 <0.0128μg/ mL），在体外测试中显示出非凡的功效，并且细胞毒性低（CC50> 10μg/ mL）。16和42的抗Leishmanial活性比两性霉素B强10倍。结构和活性关系（SAR）研究表明，3，与3-甲基-马来酰亚胺和3,4-二氯-马来酰亚胺相比，4-未取代的马来酰亚胺显示出最强的抗利什曼活性。与3-甲基-马来酰亚胺和3,4-非取代的马来酰亚胺相比，3,4-二氯-马来酰亚胺的细胞毒性最小。结果表明，一些已报道的

  DOI：

  10.3390/molecules23112878

文献信息

• Organometallic compounds and polymers made therefrom
  申请人：ELF ATOCHEM NORTH AMERICA, INC.

  公开号：EP0723967A1

  公开（公告）日：1996-07-31

  Compounds of formula (I) are disclosed: wherein L1 is a main group atom, L2 is a neutral ligand, M is a transition element or a metal element of Group 13, 14, 15, or 16 of the Periodic Table, x is the number of coordination sites of M, R1 is a polymerizable group, R2, R3, and R4 are ligands, and R5 is an anionic ligand. The compounds or monomers of formula (I) are capable of conversion to polymers by combination with one or more other known monomers, such as methyl methacrylate. Such polymers can then be added as a binder in a paint formulation to make marine antifouling coating compositions. Also described is a method to prevent fouling on surfaces wherein a composition containing a metal complex compound of formula (II): wherein M, x, L2, n, and R4 have the same meaning as in formula (I), is applied to the surface susceptible to fouling.

  公开了式 (I) 化合物： 其中 L1 是主基团原子，L2 是中性配位体，M 是过渡元素或元素周期表第 13、14、15 或 16 族金属元素，x 是 M 的配位位点数，R1 是可聚合基团，R2、R3 和 R4 是配位体，R5 是阴离子配位体。式 (I) 的化合物或单体可与一种或多种其他已知单体（如甲基丙烯酸甲酯）结合转化为聚合物。这种聚合物可作为粘合剂加入涂料配方中，制成船舶防污涂料组合物。此外，还介绍了一种防止表面结垢的方法，其中的组合物含有式 (II) 的金属络合物： 其中 M、x、L2、n 和 R4 的含义与式（I）中的含义相同。
• In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes
  申请人：California Institute of Technology

  公开号：US10208322B2

  公开（公告）日：2019-02-19

  The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.

  本发明提供了使用血红素酶催化烯烃向任何含有一个或多个环丙烷官能团的化合物转化的方法。在某些方面，本发明提供了一种生产环丙烷化产物的方法，包括提供烯烃底物、重氮试剂和血红素酶；以及在反应中将各组分混合足够长的时间以生产环丙烷化产物。在其他方面，本发明提供了能够进行体内和体外烯烃环丙烷化反应的血红素酶，包括其变体和片段。本发明还提供了表达血红素酶的表达载体和宿主细胞。
• Cytochrome P450 BM3 enzyme variants for preparation of cyclopropanes
  申请人：California Institute of Technology

  公开号：US11008596B2

  公开（公告）日：2021-05-18

  The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.

  本发明提供了利用血红素酶催化烯烃向任何含有一个或多个环丙烷官能团的化合物转化的方法。在某些方面，本发明提供了一种生产环丙烷化产物的方法，包括提供烯烃底物、重氮试剂和血红素酶；以及在反应中将各组分混合足够长的时间以生产环丙烷化产物。在其他方面，本发明提供了能够进行体内和体外烯烃环丙烷化反应的血红素酶，包括其变体和片段。本发明还提供了表达血红素酶的表达载体和宿主细胞。
• TAGGED MULTI-NUCLEOTIDES USEFUL FOR NUCLEIC ACID SEQUENCING
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3464310B1

  公开（公告）日：2021-01-27
• IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES
  申请人：California Institute of Technology

  公开号：US20170247725A1

  公开（公告）日：2017-08-31

  The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.