N-tosyl-2,3,5,6-tetramethyl-1,4-aminophenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-tosyl-2,3,5,6-tetramethyl-1,4-aminophenol
• 英文别名: N-(4-hydroxy-2,3,5,6-tetramethylphenyl)-4-methylbenzenesulfonamide
• 化学式: C₁₇H₂₁NO₃S
• 分子量: 319.425
• InChiKey: WMJNVAXWDXPOKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二硝基均四甲苯(二硝基杜烯) 在 lead(IV) acetate 、 亚磷酸氢二甲酯 、 镍 、 一水合肼 、 三乙胺 作用下， 以 乙醚 、 乙醇 、 溶剂黄146 为溶剂， 生成 N-tosyl-2,3,5,6-tetramethyl-1,4-aminophenol
  参考文献：
  名称：

  摘要：

  N-Tosyl-2,3,5,6-tetramethyl-1,4-benzoquinonimine as the other N-arylsulfonyl-1,4-benzoquinonimines with an activated C=N bond reacts along 1,2-addition path with alcohols and sodium azide and along 1,2-addition-elimination path with aromatic amines. The higher activity of the C=N bond in the N-arylsulfonyl-1,4-benzoquinonimines is not due to the electronic character of the substituent attached to the ring (Cl, CH3) but to steric influence resulting in increase in the bond angle C=N-S.

  DOI：

  10.1023/a:1013140330701

文献信息

• ——
  作者：A. P. Avdeenko、A. L. Yusina、L. M. Yagupol'skii

  DOI：10.1023/a:1013140330701

  日期：——

  N-Tosyl-2,3,5,6-tetramethyl-1,4-benzoquinonimine as the other N-arylsulfonyl-1,4-benzoquinonimines with an activated C=N bond reacts along 1,2-addition path with alcohols and sodium azide and along 1,2-addition-elimination path with aromatic amines. The higher activity of the C=N bond in the N-arylsulfonyl-1,4-benzoquinonimines is not due to the electronic character of the substituent attached to the ring (Cl, CH3) but to steric influence resulting in increase in the bond angle C=N-S.