4-(2-thiophene)6-methyl-2-pyranone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 4-(2-thiophene)6-methyl-2-pyranone
• 英文别名: 6-Methyl-4-thiophen-2-ylpyran-2-one
• 化学式: C₁₀H₈O₂S
• 分子量: 192.238
• InChiKey: UFVWTSLZEQXTNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  54.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-羟基-6-甲基-2-吡喃酮 在 1,2-双(二苯基膦)乙烷氯化镍 三乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 4-(2-thiophene)6-methyl-2-pyranone
  参考文献：
  名称：

  通过镍催化芳烃磺酸盐与有机锌试剂交叉偶联制备 4-取代-2(5H)-呋喃酮、2(1H)-喹诺酮和吡喃酮的有效途径

  摘要：

  镍 (II) 催化的 4-甲苯磺酰基-2(1H)-喹诺酮、吡喃酮和 2(5H)-呋喃酮与各种有机锌试剂的交叉偶联反应为高产...

  DOI：

  10.1246/cl.2005.796

文献信息

• [Pd(PPh3)2(saccharinate)2]—general catalyst for Suzuki–Miyaura, Negishi cross-coupling and C–H bond functionalization of coumaryl and pyrone substrates
  作者：Parin Shah、M. Dolores Santana、Joaquín García、J. Luis Serrano、Minal Naik、Suhas Pednekar、Anant R. Kapdi

  DOI：10.1016/j.tet.2012.12.030

  日期：2013.2

  The potential of complex [Pd(PPh3)(2)(saccharinate)(2)] 1 in catalyzing Suzuki-Miyaura cross-coupling of 4-halo and 4-bromomethyl coumaryl and pyrone substrates with different aryl boronic acids has been explored. Excellent yields of the desired products are obtained in competitive reaction time and under relatively mild conditions. Negishi cross-coupling of 4-coumaryl tosylate with aryl and allcylzinc reagents has also been performed with good yields of the cross-coupled products obtained in most cases. Intramolecular C-H bond functionalization of coumaryl ethers also furnished very high yields of synthetically attractive tetracyclic ring systems exhibiting the potential of I as a powerful catalyst in synthetically important reactions. (C) 2012 Elsevier Ltd. All rights reserved.
• Kalinin; Shilova; Okladnoi, Doklady Chemistry, 1996, vol. 351, # 1-3, p. 276 - 278
  作者：Kalinin、Shilova、Okladnoi、Schmidhammer

  DOI：——

  日期：——
• Efficient Route to 4-Substituted-2(5<i>H</i>)-furanones, 2(1<i>H</i>)-quinolones, and pyrones by Nickel-catalyzed Cross-coupling of Arenesulfonates with Organozinc Reagents
  作者：Jie Wu、Xiaoyu Sun、Liang Zhang

  DOI：10.1246/cl.2005.796

  日期：2005.6

  Nickel(II)-catalyzed cross-coupling reactions of 4-tosyl-2(1H)-quinolone, pyrone, and 2(5H)-furanone with various organozinc reagents provide an efficient and practical method for the high-yielding...

  镍 (II) 催化的 4-甲苯磺酰基-2(1H)-喹诺酮、吡喃酮和 2(5H)-呋喃酮与各种有机锌试剂的交叉偶联反应为高产...