2-heptyl-1-undecanoic anhydride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-heptyl-1-undecanoic anhydride
• 英文别名: 2-Heptylundecanoyl 2-heptylundecanoate；2-heptylundecanoyl 2-heptylundecanoate
• 化学式: C₃₆H₇₀O₃
• 分子量: 550.95
• InChiKey: POZCOAMVPONNQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.4
• 重原子数：
  39
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-heptyl-1-undecanoic anhydride 、 5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite] 、 2-heptylundecanoyl chloride 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 72.5h， 以67.5%的产率得到5'-O-(4,4'-dimethoxytrityl)-N⁴-(2-heptyl-1-undecanoyl)-2'-deoxycytidine-3'-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite]
  参考文献：
  名称：

  Oligonucleotide with protected base

  摘要：

  本发明提供了一种用于延伸的受保护核苷酸，可以通过液液萃取操作高效地和高产率地纯化，并且可以通过磷酰胺酯法实现寡核苷酸的生产方法。已经发现，上述问题可以通过包含受保护碱基和/或在3'-位置含有支链含芳基团的特定寡核苷酸来解决。

  公开号：

  US09371353B2

文献信息

• Oligonucleotide with protected base
  申请人：Ajinomoto Co., Inc.

  公开号：US09371353B2

  公开（公告）日：2016-06-21

  The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method. It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3′-position.

  本发明提供了一种用于延伸的受保护核苷酸，可以通过液液萃取操作高效地和高产率地纯化，并且可以通过磷酰胺酯法实现寡核苷酸的生产方法。已经发现，上述问题可以通过包含受保护碱基和/或在3'-位置含有支链含芳基团的特定寡核苷酸来解决。
• OLIGONUCLEOTIDE WITH PROTECTED BASE
  申请人：Ajinomoto Co., Inc.

  公开号：US20130267697A1

  公开（公告）日：2013-10-10

  The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method. It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3′-position.

  本发明提供了一种用于延长的受保护核苷酸，可以通过液-液萃取操作高效且高产地纯化，并且可以通过磷酰胺酯法实现寡核苷酸的生产方法。已发现上述问题可以通过包含受保护碱基和/或在3'-位置带有分支链含芳基的特定寡核苷酸来解决。
• LUBRICATING OIL ADDITIVE, LUBRICATING OIL COMPOSITION CONTAINING THE SAME, VARIOUS LOW-FRICTION SLIDING MEMBERS, ROLLING BEARING, AND SLIDING BEARING
  申请人：Idemitsu Kosan Co., Ltd.

  公开号：EP2011853A1

  公开（公告）日：2009-01-07

  Provided is an additive for lubricating oils which enhances frictional characteristics of slide parts in internal combustion engines and driving system transmission engines and which exhibit an excellent fuel consumption reducing effect. The above additive for lubricating oils comprises a heterocyclic compound having a heterocyclic skeleton originating in a compound selected from pyridines, pyrroles, pyrimidines, pyrazoles, pyridazines, indazoles, pyrazines, triazines, triazoles, tetrazoles, oxazoles, oxadiazoles, thiazoles, thiadiazoles, furans, dioxanes, pyrans and thiophenes. A lubricating oil composition containing the above additive for lubricating oils is effectively used for various low friction slide members, antifriction bearings and slide bearings.

  本发明提供了一种润滑油添加剂，它能增强内燃机和驱动系统传动发动机中滑动部件的摩擦特性，并具有出色的降低油耗效果。上述润滑油添加剂包含一种杂环化合物，其杂环骨架源自选自吡啶、吡咯、嘧啶、吡唑、哒嗪、吲唑、吡嗪、三嗪、三唑、四唑、噁唑、噁二唑、噻唑、噻二唑、呋喃、二噁烷、吡喃和噻吩的化合物。含有上述润滑油添加剂的润滑油组合物可有效地用于各种低摩擦滑动部件、减摩轴承和滑动轴承。
• BASE-PROTECTED OLIGONUCLEOTIDE
  申请人：AJINOMOTO CO., INC.

  公开号：EP2816053B1

  公开（公告）日：2021-03-24
• US8748358B2
  申请人：——

  公开号：US8748358B2

  公开（公告）日：2014-06-10