diethyl-(6-methyl-2-pyridin-4-yl-pyrimidin-4-yl)-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: diethyl-(6-methyl-2-pyridin-4-yl-pyrimidin-4-yl)-amine
• 英文别名: N,N-Diethyl-6-methyl-2-(4-pyridinyl)-4-pyrimidinamine；N,N-diethyl-6-methyl-2-pyridin-4-ylpyrimidin-4-amine
• 化学式: C₁₄H₁₈N₄
• 分子量: 242.324
• InChiKey: XKXQOVNSUKRWGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-amidinopyridine hydrochloride 在 苯膦酰二氯 、 sodium methylate 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 反应 35.0h， 生成 diethyl-(6-methyl-2-pyridin-4-yl-pyrimidin-4-yl)-amine
  参考文献：
  名称：

  Novel orally active inhibitors of passive cutaneous anaphylaxis in rats: N-[2-(4-Pyridinyl)-4-pyrimidinyl] ureas and dialkyl [[[2-(4-pyridinyl)-4-pyrimidinyl]amino]methylene]malonates

  摘要：

  4-Chloro-2-(4-pyridinyl)pyrimidines were treated with alkylamines to afford the corresponding N-substituted amino derivatives. 4-Amino-2-(4-pyridinyl)pyrimidines and their N-substituted analogues were converted to amides, carbamates, aminomethylenemalonates, and ureas. Many of these compounds were found to have potential antiallergic activity as indicated by the rat passive cutaneous anaphylaxis screen. The most compounds were found in the last two series.

  DOI：

  10.1021/jm00349a014

文献信息

• Ranunculus asiaticus plant named ‘ABIZANAGI’
  申请人：Biancheri Alberto

  公开号：USPP030024P3

  公开（公告）日：2018-12-25

  A new and distinct Ranunculus cultivar plant named ‘ABIZANAGI’ is disclosed, characterized by deep magenta colored flowers. Plants are highly productive and consistently produce quality flowers through the season. Flower stems are above average in length. The new variety is a Ranunculus , normally produced as a cut flower and also potentially useful as an ornamental plant.

  本发明公开了一种新的独特的毛茛属植物品种，命名为“ABIZANAGI”，其特征为深洋红色的花朵。该植物高产，并在整个季节内始终产生高质量的花朵。花茎长度高于平均水平。这种新品种是一种毛茛属植物，通常用作切花，也有可能用作观赏植物。
• 4-Amino (or halo or hydroxy or hydrazino)-2-(pyridinyl)pyrimidines
  申请人：Sterling Drug Inc.

  公开号：US04032523A1

  公开（公告）日：1977-06-28

  Compounds useful as anti-allergic agents are 2-Q-4-[XZC=C(R)NH]-5-R.sub.1 -6-R.sub.2 -pyrimidines (I), where Q is 4- or 3- or 2-pyridinyl or 4- or 3- or 2-pyridinyl having one or two lower-alkyl substituents or N-oxide thereof, R is hydrogen or lower-alkyl, R.sub.1 is hydrogen, lower-alkyl or cyano, R.sub.2 is hydrogen, lower-alkyl, hydroxy or halo, X and Z are the same or different and are each selected from lower-carbalkoxy, lower-alkanoyl, carbamyl and cyano, or ##STR1## is ##STR2## where R.sub.3 and R.sub.4 are each lower-alkyl, or X is hydrogen, are prepared by reacting 4-amino-2-Q-5-R.sub.1 -6-R.sub.2 -pyrimidine (II where Q' is amino) with R'O--C(R)=CXZ (III). Preparations of II are given. Also shown as intermediates and/or anti-allergic agents are 4-(AcNH)-2-Q-5-R.sub.1 -6-R.sub.2 -pyrimidines (IV) and 4-(R.sub.5 R.sub.6 N)-2-Q-5-R.sub.1 -6-R.sub.2 -pyrimidines (V) where Ac is lower-alkanoyl or lower-carbalkoxy, R.sub.5 is hydrogen, lower-alkyl or lower-hydroxyalkyl, and R.sub.6 is lower-alkyl or lower-hydroxyalkyl.

  有用作为抗过敏剂的化合物是2-Q-4-[XZC=C(R)NH]-5-R.sub.1 -6-R.sub.2 -嘧啶（I），其中Q是4-或3-或2-吡啶基或有一个或两个较低烷基取代基或其N-氧化物，R是氢或较低烷基，R.sub.1是氢，较低烷基或氰基，R.sub.2是氢，较低烷基，羟基或卤素，X和Z相同或不同，各自选择自较低羰基烷氧基，较低烷酰基，氨基甲酰基和氰基，或##STR1##是##STR2##其中R.sub.3和R.sub.4是各自的较低烷基，或X是氢，通过将4-氨基-2-Q-5-R.sub.1 -6-R.sub.2 -嘧啶（其中Q'是氨基）与R'O--C(R)=CXZ（III）反应制备。给出了II的制备方法。4-(AcNH)-2-Q-5-R.sub.1 -6-R.sub.2 -嘧啶（IV）和4-(R.sub.5 R.sub.6 N)-2-Q-5-R.sub.1 -6-R.sub.2 -嘧啶（V）也显示为中间体和/或抗过敏剂，其中Ac是较低烷酰基或较低羰基烷氧基，R.sub.5是氢，较低烷基或较低羟基烷基，R.sub.6是较低烷基或较低羟基烷基。
• US4032523A
  申请人：——

  公开号：US4032523A

  公开（公告）日：1977-06-28
• US4018770A
  申请人：——

  公开号：US4018770A

  公开（公告）日：1977-04-19
• US4086233A
  申请人：——

  公开号：US4086233A

  公开（公告）日：1978-04-25