trimethylsilylpropynal tetramethylethylene acetal

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧戊环
• 英文名称: trimethylsilylpropynal tetramethylethylene acetal
• 英文别名: Trimethyl-[2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)ethynyl]silane
• 化学式: C₁₂H₂₂O₂Si
• 分子量: 226.391
• InChiKey: RGJMWJWLYIEHLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  对苯二甲醛 、 trimethylsilylpropynal tetramethylethylene acetal 在 titanium(IV) isopropylate 异丙基溴化镁 、 盐酸 作用下， 以 乙醚 、 四氢呋喃 、 乙醇 为溶剂， 反应 5.0h， 以75%的产率得到1,4-二(呋喃-2-基)苯
  参考文献：
  名称：

  One-pot preparation of 2-substituted and 2,3-disubstituted furans from 2-alkynal tetramethylethylene acetals and aldehydes using a divalent titanium reagent Ti(O-i-Pr)4/2 i-PrMgX

  摘要：

  Sequential treatment of 2-alkynal tetramethylethylene acetals with a divalent titanium reagent Ti(O-i-Pr)(4)/2 i-PrMgX and aldehydes gave, after acidic work-up, furans in good to excellent yields, thus providing a new efficient one-pot access to a variety of 2-substituted and 2,3-disubstituted furans including those having a functionalized substituent(s). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01068-1

文献信息

• One-pot preparation of 2-substituted and 2,3-disubstituted furans from 2-alkynal tetramethylethylene acetals and aldehydes using a divalent titanium reagent Ti(O-i-Pr)4/2 i-PrMgX
  作者：Xin Teng、Takeshi Wada、Sentaro Okamoto、Fumie Sato

  DOI：10.1016/s0040-4039(01)01068-1

  日期：2001.8

  Sequential treatment of 2-alkynal tetramethylethylene acetals with a divalent titanium reagent Ti(O-i-Pr)(4)/2 i-PrMgX and aldehydes gave, after acidic work-up, furans in good to excellent yields, thus providing a new efficient one-pot access to a variety of 2-substituted and 2,3-disubstituted furans including those having a functionalized substituent(s). (C) 2001 Elsevier Science Ltd. All rights reserved.