1-chloro-3-fluorohexane

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: 1-chloro-3-fluorohexane
• 化学式: C₆H₁₂ClF
• 分子量: 138.613
• InChiKey: XNWDBKSDHYEDGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-己烯 、 N,N-二氯-N-甲胺 、 三氟化硼 以12%的产率得到
  参考文献：
  名称：

  HEASLEY, G. E.;JANES, J. M.;STARK, S. R.;ROBINSON, B. L.;HEASLEY, V. L.;S+, TETRAHEDRON LETT., 1985, 26, N 15, 1811-1814

  摘要：

  DOI：

文献信息

• Elemental fluorine. Part 19: Electrophilic fluorination of hexyl derivatives bearing electron withdrawing groups
  作者：Richard D. Chambers、Mandy Parsons、Graham Sandford、Emmanuelle Thomas、Jelena Trmcic、John S. Moilliet

  DOI：10.1016/j.tet.2006.03.113

  日期：2006.7

  Reaction of a series of model hexyl derivatives of the form C6H13–X (X=Cl, Br, I, CO2Me, COMe, CHO) with both elemental fluorine and Selectfluor™ was studied in order to assess the impact of electron withdrawing functional groups upon fluorination of an alkyl chain. Fluorination generally occurs at secondary sites, with a slight preference for those that are furthest removed from the electron withdrawing

  研究了一系列形式为C 6 H 13 –X（X = Cl，Br，I，CO 2 Me，COMe，CHO）的模型己基衍生物与元素氟和Selectfluor™的反应，以评估氟的影响。烷基链氟化时的吸电子官能团。氟化通常发生在次要位置，与亲电子取代过程一致，略微偏爱从吸电子基团离得最远的位置，尽管在大多数情况下会获得氟化产物的混合物。
• Boron trifluoride promoted reactions of n-haloelectrophiles with alkenes
  作者：Gene E. Heasley、J. Mark Janes、Stephen R. Stark、Brian L. Robinson、Victor L. Heasley、Dale F. Shellhamer

  DOI：10.1016/s0040-4039(00)94744-0

  日期：1985.1

  N-Haloelectrophiles react with alkenes in the presence of boron rifluoride etherate to give halofluorides and N-halo adducts.

  N-卤代亲电子试剂在氟氟化硼醚化物的存在下与烯烃反应，生成卤代氟化物和N-卤代加合物。
• PREPARATION OF SELECTIVELY FLUORINATED ORGANIC COMPOUNDS
  申请人：F2 Chemicals Limited

  公开号：EP1165464B1

  公开（公告）日：2003-08-20
• [EN] PREPARATION OF SELECTIVELY FLUORINATED ORGANIC COMPOUNDS<br/>[FR] PREPARATION DE COMPOSES ORGANIQUES FLUORES DE FAÇON SELECTIVE
  申请人：F2 CHEMICALS LIMITED

  公开号：WO2000058241A1

  公开（公告）日：2000-10-05

  The invention provides a method of selectively fluorinating an organic compound at an unactivated saturated sp3 hybridised carbon atom, the method comprising reacting the compound with a fluorinating agent containing an N-F bond. The carbon atom may be, for example, a tertiary carbon atom or a secondary carbon atom. The carbon atom may form part of a cyclic structure. The fluorinating agent may be any electrophilic fluorinating agent containing an N-F bond. Preferably, the fluorinating agent is an N-fluorinated diazoniabicycloalkane.