1-(3'-pyridyl)-2-bromoethanol* hydrobromide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(3'-pyridyl)-2-bromoethanol* hydrobromide
• 英文别名: 2-Bromo-1-pyridin-3-ylethanol;hydrobromide
• 化学式: BrH*C₇H₈BrNO
• 分子量: 282.963
• InChiKey: TYBIIBNASRJZOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.09
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  33.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(3'-pyridyl)-2-bromoethanol* hydrobromide 在 N,N-二异丙基乙胺 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(pyridin-3-yl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide
  参考文献：
  名称：

  2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

  摘要：

  A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.102

文献信息

• Aryloxymethyl derivatives of nitrogenous heterocyclic methanols and
  申请人：A. H. Robins Company, Incorporated

  公开号：US04835164A1

  公开（公告）日：1989-05-30

  Novel heterocyclicmethanols are disclosed having the formula: ##STR1## wherein Z is pyrrolidinyl, piperidinyl, homopiperidinyl or pyridinyl; R.sup.1 is hydrogen, loweralkyl or carbethoxymethyl; R.sup.2 is hydrogen, loweralkyl, cycloalkyl, phenyl or phenyl-loweralkyl; R.sup.3 is 1 or 2-naphthalenyl, 2,3-dihydroinden-4 or 5-yl, phenyl or phenyl substituted by loweralkyl, loweralkoxy, halogen, trifluoromethyl, phenyl, methylenedioxy, nitro, amino, loweralkylamino, diloweralkylamino, loweracylamino; the 1-position of 2-pyrrolidinyl, 2-piperidinyl or 2-homopiperidinyl may be substituted by an R.sup.4 loweralkyl group, or R.sup.1 may form methylene or --CH.sub.2 -C(O)-bridges with R.sup.4 ; the pharmaceutically acceptable salts and diastereomers thereof, which compounds have antiarrhythmic and/or hypotensive activity in animals.

  公开了具有以下式子的新型杂环甲醇：##STR1## 其中Z为吡咯烷基，哌啶基，同哌啶基或吡啶基; R.sup.1为氢，低碳基或羰乙氧甲基; R.sup.2为氢，低碳基，环烷基，苯基或苯基-低碳基; R.sup.3为1或2-萘基，2,3-二氢吲哚-4或5-基，苯基或被低碳基，低碳氧基，卤素，三氟甲基，苯基，亚甲二氧基，硝基，氨基，低碳基氨基，二低碳基氨基，低酰胺基取代的苯基; 2-吡咯烷基，2-哌啶基或2-同哌啶基的1-位置可以被R.sup.4的低碳基取代，或者R.sup.1可以与R.sup.4形成亚甲基或--CH.sub.2-C(O)-桥。这些化合物及其药学上可接受的盐和对映异构体在动物中具有抗心律失常和/或降压活性。
• Aryloxymethyl derivatives of nitrogenous heterocyclic methanols and ethers thereof having cardiovascular activity
  申请人：A.H. ROBINS COMPANY, INCORPORATED

  公开号：EP0279707A2

  公开（公告）日：1988-08-24

  Novel heterocyclicmethanols are disclosed having the formula: wherein Z is pyrrolidinyl, piperidinyl, homopiperidinyl or pyridinyl;     R¹ is hydrogen, loweralkyl or carbethoxymethyl;     R² is hydrogen, loweralkyl or cycloalkyl, phenyl or phenyl-loweralkyl;     R³ is 1 or 2-naphthalenyl, 2,3-dihydroinden-4 or 5-yl, phenyl or phenyl substituted by loweralkyl, loweralkoxy, halogen, trifluoromethyl, phenyl, methylenedioxy, nitro, amino, loweralkylamino, diloweralkylamino, loweracylamino;     the 1-position of 2-pyrrolidinyl, 2-piperidinyl or 2-homopiperidinyl may be substituted by an R⁴ loweralkyl group, or R¹ may form methylene or -CH₂-C(O)- bridges with R⁴;     the pharmaceutically acceptable salts and diastereomers thereof, which compounds have antiarrhythmic and/or hypotensive activity in animals.

  公开了具有以下式子的新型杂环甲醇： 其中 Z 是吡咯烷基、哌啶基、均哌啶基或吡啶基； R¹ 是氢、低级烷基或碳氧甲基； R² 是氢、低级烷基或环烷基、苯基或苯基-低级烷基； R³ 是 1 或 2-萘基、2,3-二氢茚-4 或 5-基、苯基或被低级烷基、低级烷氧基、卤素、三氟甲基、苯基、亚甲基二氧基、硝基、氨基、低级烷基氨基、稀释低级烷基氨基、低级酰基氨基取代的苯基； 2-吡咯烷基、2-哌啶基或 2-高哌啶基的 1-位可被 R⁴ 低烷基取代，或 R¹ 可与 R⁴ 形成亚甲基或-CH₂-C(O)-桥； 其药学上可接受的盐和非对映异构体，这些化合物在动物体内具有抗心律失常和/或降血压活性。
• US4835164A
  申请人：——

  公开号：US4835164A

  公开（公告）日：1989-05-30
• 2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases
  作者：Mark E. Schnute、David J. Anderson、Roger J. Brideau、Fred L. Ciske、Sarah A. Collier、Michele M. Cudahy、MariJean Eggen、Michael J. Genin、Todd A. Hopkins、Thomas M. Judge、Euibong J. Kim、Mary L. Knechtel、Sajiv K. Nair、James A. Nieman、Nancee L. Oien、Allen Scott、Steven P. Tanis、Valerie A. Vaillancourt、Michael W. Wathen、Janet L. Wieber

  DOI：10.1016/j.bmcl.2007.03.102

  日期：2007.6

  A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases. (c) 2007 Elsevier Ltd. All rights reserved.