2,4-bis-(3-nitrophenyl)-1,3,5-triazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-bis-(3-nitrophenyl)-1,3,5-triazine
• 英文别名: 2,4-bis-(3-nitro-phenyl)-[1,3,5]triazine；2,4-Bis(3-nitrophenyl)-1,3,5-triazine
• 化学式: C₁₅H₉N₅O₄
• 分子量: 323.268
• InChiKey: SAJFRSKAFOGJCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  130
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-(甲氧基甲烯基)-2,2-二甲基-1,3-二氧己环-4,6-二酮 、 3-硝基苯甲脒 盐酸盐 在 potassium tert-butylate 作用下， 以 甲醇 为溶剂， 以52%的产率得到2,4-bis-(3-nitrophenyl)-1,3,5-triazine
  参考文献：
  名称：

  A simple synthesis of 2,4-diaryl-1,3,5-triazines

  摘要：

  Arylamidines 2 react with 5-methoxymethylen-2,2-dimethyl-1,3-dioxan-4,6-dione 5 to give 2,4-diaryl-1,3,5-triazines in moderate to good yields. 5 can be comprehended as a formic acid derivative which transfers a C-1-building block. Other formic acid derivatives give only poor to moderate yields of triazines by treatment with amidines. The synthetic method is applicable to aromatic amidines.

  DOI：

  10.1007/bf00811762

文献信息

• C-H Functionalization and C-N Bond Formation Approaches under Catalytic Conditions for the Synthesis of α-Ketoamides and 2,4-Disubstituted-1,3,5-triazines
  作者：Laimujam Sidartha Singh、Arup K. Kabi、Ragini Sengupta、Anupam Roy、Abhishek Sahoo、Indranil Saha、Chandi C. Malakar

  DOI：10.14233/ajchem.2022.23769

  日期：——

  This work describes an easy way to perform approach for the transformation of arylmethyl ketones to α-ketoamides using secondary amines as starting materials in the presence of iodine as a catalyst in water under peroxide free reaction conditions. The established amidation reaction proceeds via α-C(sp3)-H functionalization and C-N bond formation approaches in water at ambient temperature. On the other hand, a novel and straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via nickel-catalyzed cyclization of amidines with DMSO as one-carbon synthon has been developed. The developed strategy proceeds via C-N bond formation.

  这项工作描述了一种易于实施的方法，利用二级胺作为起始物，在碘催化下，在不使用过氧化物的反应条件下，在水中将芳基甲基酮转化为α-酮酰胺。建立的酰胺化反应通过α-C(sp3)-H官能团化和C-N键形成方法在室温下在水中进行。另一方面，通过DMSO作为一碳合成体的铜催化的酰胺环化反应，开发了一种新颖而简单的2,4-二取代-1,3,5-三嗪合成方法。所开发的策略通过C-N键形成进行。
• A simple synthesis of 2,4-diaryl-1,3,5-triazines
  作者：P. Wessig、J. Schwarz

  DOI：10.1007/bf00811762

  日期：1995.1

  Arylamidines 2 react with 5-methoxymethylen-2,2-dimethyl-1,3-dioxan-4,6-dione 5 to give 2,4-diaryl-1,3,5-triazines in moderate to good yields. 5 can be comprehended as a formic acid derivative which transfers a C-1-building block. Other formic acid derivatives give only poor to moderate yields of triazines by treatment with amidines. The synthetic method is applicable to aromatic amidines.