1-(pentan-2-yl)pyrrolidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(pentan-2-yl)pyrrolidine
• 英文别名: 1-(1-methyl-butyl)-pyrrolidine；1-(1-Methyl-butyl)-pyrrolidin；1-Pentan-2-ylpyrrolidine
• 化学式: C₉H₁₉N
• 分子量: 141.257
• InChiKey: CBUMFZKOKPMYIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 2-戊醇 在 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 双(2-二苯基磷苯基)醚 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 24.17h， 以72%的产率得到1-(pentan-2-yl)pyrrolidine
  参考文献：
  名称：

  Hamid, M. Haniti S. A.; Allen, C. Liana; Lamb, Gareth W., Journal of the American Chemical Society, 2009, vol. 131, p. 1766 - 1774

  摘要：

  DOI：

文献信息

• Photometric Characterization of the Reductive Amination Scope of the Imine Reductases from<i>Streptomyces tsukubaensis</i>and<i>Streptomyces ipomoeae</i>
  作者：Philipp Matzel、Lukas Krautschick、Matthias Höhne

  DOI：10.1002/cbic.201700257

  日期：2017.10.18

  reductive amination catalyzed by two promising imine reductases is established in a rapid photometric NADPH assay. Substrates ranging from aldehydes to ketones and from primary to secondary amines are accepted, thus giving access to various secondary and tertiary amine products.

  两种酶663种组合：在快速光度NADPH分析中确定了由两种有前途的亚胺还原酶催化的还原胺化中的底物范围。可以接受从醛到酮以及从伯胺到仲胺的各种底物，因此可以使用各种仲胺和叔胺产品。
• [EN] COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY<br/>[FR] COMPOSÉS POUR LE TRAITEMENT D'UNE AMYOTROPHIE SPINALE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2016184832A1

  公开（公告）日：2016-11-24

  The present invention provides compounds of formula (I) wherein A, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

  本发明提供了如下式（I）中的化合物，其中A、X、Y、R1和R2如本文所述，以及其药学上可接受的盐。此外，本发明涉及制造如式（I）中的化合物，包括含有它们的药物组合物以及它们作为药物的用途。
• Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists
  申请人：Santhera Pharmaceuticals (Schweiz) AG

  公开号：EP1974729A1

  公开（公告）日：2008-10-01

  The present invention relates to substituted imidazopyridine derivatives as melanocortin-4 receptor (MC-4R) modulators, in particular as melanocortin 4 receptor antagonists. The antagonists are useful for the treatment of disorders and diseases such as cancer cachexia, muscle wasting, anorexia, anxiety and depression.

  本发明涉及取代咪唑吡啶衍生物作为黑色素皮质素-4受体（MC-4R）调节剂，特别是作为黑色素皮质素4受体拮抗剂。这些拮抗剂对于治疗癌症消瘦，肌肉萎缩，厌食症，焦虑和抑郁等疾病和疾病是有用的。
• Selective removal of aromatics
  申请人：BP Oil International Limited

  公开号：EP2338955A1

  公开（公告）日：2011-06-29

  According to the present invention there is provided a process for reducing the concentration of one or more aromatic compounds in a feedstock comprising one or more aromatic compounds and one or more olefinic compounds, which process comprises contacting the feedstock with an ionic liquid comprising an anionic component and a cationic component to produce a product with a higher mole ratio of olefinic compounds to aromatic compounds than the feedstock, and an ionic liquid phase with a lower mole ratio of olefinic compounds to aromatic compounds than the feedstock, wherein the surface charge profile of the cationic component has a maximum value at a charge density value (σ) in the range -0.0085 < σ < -0.0040 e/Å2, and wherein from 25% to 65% of the molecular surface area of the anionic component has a charge density value (σ) in the range -0.0085 < σ < +0.0085 e/Å2, where e represents the charge of an electron.

  根据本发明，提供了一种用于降低由一种或多种芳香族化合物和一种或多种烯烃化合物组成的原料中的一种或多种芳香族化合物浓度的工艺，该工艺包括将原料与由阴离子组分和阳离子组分组成的离子液体接触，生成烯烃化合物与芳香族化合物摩尔比高于原料的产物、和烯烃化合物与芳香族化合物的摩尔比低于原料的离子液相，其中阳离子组分的表面电荷谱在电荷密度值(σ)在-0.0085＜σ＜-0.0040e/Å2，其中25％至65％的阴离子组分分子表面积的电荷密度值(σ)在-0.0085＜σ＜+0.0085e/Å2的范围内，其中e代表电子的电荷。
• Material for electrolytic solution, ionic material-containing composition and use thereof
  申请人：Nippon Shokubai Co., Ltd.

  公开号：EP2565886A1

  公开（公告）日：2013-03-06

  An object of the present invention is to provide a material for an electrolytic solution having improved ionic conductivity and, showing excellent in low temperature property, being stable with time, and being electrochemically stable at a high potential, and an ionic material-containing composition exhibiting excellent fundamental performance such as electrochemical stability, and preferably used in a variety of utilities. Another object of the present invention is to provide utilities thereof. The material for an electrolytic solution is the material containing an ionic compound, and the material comprises a cyano group-containing anion represented by the formula (1) ; , and 1 to 99% by mass of a solvent in 100% by mass of the material for an electrolytic solution.

  本发明的一个目的是提供一种用于电解溶液的材料，该材料具有更好的离子导电性，并且在低温下表现出优异的性能，随时间变化稳定，在高电位下电化学稳定，以及一种含有离子材料的组合物，该组合物表现出优异的基本性能，如电化学稳定性，最好用于各种公用事业。本发明的另一个目的是提供其实用性。 用于电解溶液的材料是含有离子化合物的材料，该材料包括由式（1）表示的含氰基阴离子； 以及在 100%质量的电解溶液用材料中含有 1 至 99%质量的溶剂。