N,N'-(ethane-1,2-diyl)bis(1-(2,4-dichlorophenyl)methanimine) | 157982-80-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-(ethane-1,2-diyl)bis(1-(2,4-dichlorophenyl)methanimine)
• 英文别名: n,n'-Bis(2,4-dichlorobenzylidene)ethylenediamine；1-(2,4-dichlorophenyl)-N-[2-[(2,4-dichlorophenyl)methylideneamino]ethyl]methanimine
• CAS: 157982-80-4
• 化学式: C₁₆H₁₂Cl₄N₂
• 分子量: 374.097
• InChiKey: LEQRXQOSITZTTI-UHFFFAOYSA-N

物化性质

• 沸点：
  472.6±45.0 °C(Predicted)
• 密度：
  1.33±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  24.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-(ethane-1,2-diyl)bis(1-(2,4-dichlorophenyl)methanimine) 在 sodium tetrahydroborate 、 盐酸 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and tripanocidal activity of ferrocenyl and benzyl diamines against Trypanosoma brucei and Trypanosoma cruzi

  摘要：

  Trypanosoma brucei and Trypanosoma cruzi are the etiologic agents of sleeping sickness and Chagas disease, respectively, two of the 17 preventable tropical infectious diseases (NTD) which have been neglected by governments and organizations working in the health sector, as well as pharmaceutical industries. High toxicity and resistance are problems of the conventional drugs employed against trypanosomiasis, hence the need for the development of new drugs with trypanocidal activity. In this work we have evaluated the trypanocidal activity of a series of N1, N2-dibenzylethane-1,2-diamine hydrochlorides (benzyl diamines) and N1-benzyl, N2-methyferrocenylethane-1,2-diamine hydrochlorides (ferrocenyl diamines) against T. brucei and T. cruzi parasite strains. We show that incorporation of the ferrocenyl group into the benzyl diamines increases the trypanocidal activity. The molecules exhibit potential trypanocidal activity in vitro against all parasite strains. Cytotoxicity assay was also carried out to evaluate the toxicity in HepG2 cells. (c) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.02.046
• 作为产物：
  描述：

  2,4-二氯苯甲醛 、 乙二胺 以 乙醇 为溶剂， 反应 3.0h， 以88%的产率得到N,N'-(ethane-1,2-diyl)bis(1-(2,4-dichlorophenyl)methanimine)
  参考文献：
  名称：

  二亚胺基铜（i）配合物在光氧化还原催化中的设计和应用。

  摘要：

  以高度模块化的方式制备结构不同的双（亚氨基）铜（i）配合物，并将其用作苯乙烯和烷基卤化物的ATRA反应中的铜基光催化剂。新的光催化剂显示出良好的催化活性并确保了有效的化学转化。

  DOI：

  10.1039/c9ob01331h

文献信息

• FUNCTIONALIZATION OF 1-AMINO-1-ARYLMETHYL PHOSPHONIC ACID DIETHYL ESTERS AT THE NH GROUP
  作者：Salvatore Failla、Paolo Finocchiaro、Giorgio La Rosa

  DOI：10.1080/10426509608046392

  日期：1996.6.1

  Functionalization at the NH group (s) of 1-amino-1-arylmethyl phosphonic acid diethyl esters with mono-isocyanates was performed in order to produce alkyl ureas bearing the phosphonate group. The condensation reaction is easily performed in dry toluene at 80 degrees C using a catalytic amount of Et(3)N, and the white crystalline products are obtained in satisfactory yields. Characterizations of these new compounds, of potential applications in agrochemistry, were performed by H-1-NMR spectroscopy and by MS-FAB spectrometry, which reveals the presence of very diagnostic signals or peaks for structural assignments.