4-methyl-6-(2,4-dichlorophenyl)-N-(2-chlorophenyl)-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-6-(2,4-dichlorophenyl)-N-(2-chlorophenyl)-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamide
• 英文别名: N-(2-chlorophenyl)-4-(2,4-dichlorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
• 化学式: C₁₈H₁₄Cl₃N₃OS
• 分子量: 426.754
• InChiKey: OYVSMFBHKMMONQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  85.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氯乙酰乙酰替苯胺 、 2,4-二氯苯甲醛 、 硫脲 以82%的产率得到4-methyl-6-(2,4-dichlorophenyl)-N-(2-chlorophenyl)-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamide
  参考文献：
  名称：

  Synthesis and antimicrobial activity of N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides

  摘要：

  Three-component reactions of acetoacetic acid N-arylamides, aromatic aldehydes, and thiourea afforded N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. Structure and antimicrobial activity of the compounds obtained were examined.

  DOI：

  10.1134/s107036321612015x

文献信息

• Synthesis and antimicrobial activity of N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides
  作者：V. L. Gein、T. M. Zamaraeva、A. V. Balandina、M. V. Dmitriev

  DOI：10.1134/s107036321612015x

  日期：2016.12

  Three-component reactions of acetoacetic acid N-arylamides, aromatic aldehydes, and thiourea afforded N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. Structure and antimicrobial activity of the compounds obtained were examined.