1,2-bis(1-phospholano)ethane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 金属杂环化合物
• 英文名称: 1,2-bis(1-phospholano)ethane
• 英文别名: 1,2-diphospholanoethane；bis(phosphanyl)ethane；1-[2-(Phospholan-1-yl)ethyl]phospholane
• 化学式: C₁₀H₂₀P₂
• 分子量: 202.216
• InChiKey: KBYIBPNDDLGOML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,2-bis(1-phospholano)ethane 、 (dmpe)₂FeCl₂ 以 四氢呋喃 为溶剂， 生成 trans-Fe(1,2-diphospholanoethane)(1,2-bis(dimethylphosphino)ethane)Cl2
  参考文献：
  名称：

  Iron(II) Complexes Containing the 1,2-Diphospholanoethane Ligand

  摘要：

  The synthesis and crystal structure of cis-Fe(BPE5)(2)Cl-2 (BPE5 = 1,2-diphospholanoethane). the first symmetrical cis-Fr(PP)(2)Cl-2 (PP = bidentate phosphine), is reported (monoclinic. P2(1)/n, a = 12.084(3) Angstrom, b = 14.059(2) Angstrom, c = 17.665(2) Angstrom, beta = 101.77(1)degrees, Z = 4). The overall structure and Fe-P and Fe-CI bend lengths of cis-Fe(BPE5)(2)Cl-2 more closely resemble those in Fe(PP3)Cl-2 complexes (PP3 = tripodal, tetradentate phosphine ligand) than in other Fe(PP)(2)Cl-2 complexes. In solution, cis-Fe(BPE5)(2)Cl-2 exhibits temperature-dependent paramagnetic behavior due to reversible dissociation of chloride. The dissociation of chloride was exploited in the synthesis of Fe(BPE5)(2)X-2 (X = Br, I) and [Fe(BPE5)(2)(L)(CI)](+). (L = CO, PMe3). The crystal structure of [cis-Fe(BPE5)(2)-(CO)(Cl)][BPh4] is reported (monoclinic, P2(1)/a, a = 12.938(3) Angstrom, b = 29.647(4) Angstrom, c = 13.131(3) Angstrom, beta = 107.89(2)degrees, Z = 4). The relative chelation strength of BPES in Fe(PP)(2)Cl-2 complexes is BPE5 approximate to DMPE > DEPE > DPrPE [DMPE = 1,2-bis(dimethylphoshino)ethane: DEPE = 1,2-bis(diethylphoshino)ethane; DPrPE = bis(di-n-propylphosphino)ethane].

  DOI：

  10.1021/ic9701928

文献信息

• Asymmetric hydrogenation of &bgr;-keto esters
  申请人：BASF Aktienegesellschaft

  公开号：US06359165B1

  公开（公告）日：2002-03-19

  Enantiomerically pure &bgr;-hydroxy esters are prepared by a process in which &bgr;-keto esters are reacted with hydrogen in the presence of catalysts of the formula LRuX2 where X is halogen, acetate, allyl, methallyl, 2-phenylallyl, perchlorate, trifluoroacetate, tetrafluoroborate, hexafluoroantimonate, hexafluorophosphate, hexafluoroarsenate or trichloroacetate, L is a bidentate phospholane of the formula I  where B=a bridging link with 1-5 carbon atoms between the two phosphorus atoms, R1=H, C1-C6-alkyl, aryl, alkylaryl or SiR23, R2=alkyl or aryl, m=0 or 1, R3=H or OR4, and R4=R1, with the proviso that if m=1 then R3=H and if m=0 then R3 ≠ H.

  对映纯度的β-羟基酯通过以下过程制备：在催化剂LRuX2存在下，β-酮酯与氢反应，其中 X为卤素、乙酸酯、烯丙基、甲基烯丙基、2-苯基烯丙基、高氯酸盐、三氟乙酸盐、四氟硼酸盐、六氟锑酸盐、六氟磷酸盐、六氟砷酸盐或三氯乙酸盐， L为具有以下式I的双齿膦烷 其中 B=连接两个磷原子的1-5个碳原子的桥链， R1=H、C1-C6-烷基、芳基、烷基芳基或SiR23， R2=烷基或芳基， m=0或1， R3=H或OR4，以及 R4=R1， 但条件是如果m=1，则R3=H，如果m=0，则R3≠H。
• Inter- and Intramolecular Thermal Activation of sp³ C−H Bonds with Ruthenium Bisallyl Complexes
  作者：Christian Six、Barbara Gabor、Helmar Görls、Richard Mynott、Petra Philipps、Walter Leitner

  DOI：10.1021/om990229r

  日期：1999.8.1

  of 1.9 h-1 was observed using complex 5a under refluxing conditions without the need of a hydrogen scavenger. A maximum total number of 5 catalytic turnovers was achieved after 48 h. Ligand degradation by dehydrogenation was detected under catalytic conditions, presumably initiated via intramolecular C−H activation as in species of type 8. Attempts to utilize complexes 5 for C−H activation in scCO2

  [R 2 P（CH 2）n PR 2 } Ru（2-Me-​​all）2 ]类型的络合物（2-Me-​​all = 2-甲基丙烯基； R = Cy，n = 1-3，5a - c ; R = Me，n = 2，6 ; R 2 = -（CH 2）4-，n = 2，7）是由相应的富电子二膦与[（cod）Ru（2- Me-all）2 ]（4）在50-70°C下。新的配合物通过多核NMR光谱和质谱技术进行了充分表征。反应4用Cy 2 P（CH 2）Ñ PCY 2含有与烃类桥Ñ = 3（图1C）和Ñ = 4（图1D），在95和50℃，分别导致[κ 2 P，P' - （η 3 -C 6 ħ 8）的CyP（CH 2）ñ PCY 2 }钌（η 3 -C 8 ħ 13）]（ñ = 3,4;8c，d）通过分子内CH键活化和伴随的氢化物转移到环辛二烯。8c的分子结构通过多核1D和2D NMR光谱法明确分配，
• Process for Producing Aliskiren
  申请人：Taddei Maurizio

  公开号：US20130071899A1

  公开（公告）日：2013-03-21

  A new route of synthesis of the compound Aliskiren of formula (I), used in the treatment of hypertension, is described.

  描述了一种用于治疗高血压的化合物阿利司钠（分子式为（I））的新合成途径。
• Field, Leslie D.; Thomas, Iain P., Inorganic Chemistry, <hi>1996</hi>, vol. 35, # 9, p. 2546 - 2548
  作者：Field, Leslie D.、Thomas, Iain P.

  DOI：——

  日期：——
• JPH11100393A
  申请人：——

  公开号：JPH11100393A

  公开（公告）日：1999-04-13