3-(2-piperidinoethylamino)indazole hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 3-(2-piperidinoethylamino)indazole hydrochloride
• 英文别名: N-(2-piperidin-1-ylethyl)-1H-indazol-3-amine;hydrochloride
• 化学式: C₁₄H₂₀N₄*ClH
• 分子量: 280.801
• InChiKey: CWZVIMXLLNFOPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.88
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  44
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(2-piperidinoethylamino)indazole 、 盐酸 在 ice 、 乙醚 作用下， 以 乙醇 为溶剂， 以to give 3-(2-piperidinoethylamino)indazole hydrochloride的产率得到3-(2-piperidinoethylamino)indazole hydrochloride
  参考文献：
  名称：

  3-aminoindazole derivatives

  摘要：

  化合物的公式(I)：##STR1## 其中W.sub.1为氢原子或##STR2##其中Y是C.sub.1-6烷基或具有C.sub.1-6烷基取代基的C.sub.1-6烷基；R.sub.1和R.sub.2各自独立地为氢原子或C.sub.1-6烷基，且R.sub.1和R.sub.2可以与相邻氮原子一起形成C.sub.4-6杂环或含氮C.sub.4-6杂环，而C.sub.4-6杂环可以具有至少一个C.sub.1-6烷基，羟基或卤素原子；W.sub.2为氢原子或##STR3##其中Z是C.sub.1-6烷基或具有C.sub.1-6烷基取代基的C.sub.1-6烷基；R.sub.3和R.sub.4各自独立地为氢原子或C.sub.1-6烷基，且R.sub.3和R.sub.4可以与相邻氮原子一起形成C.sub.4-6杂环或含氮C.sub.4-6杂环，而C.sub.4-6杂环可以具有至少一个C.sub.1-6烷基，羟基或卤素原子；当W.sub.1为氢原子时，W.sub.2为##STR4##当W.sub.2为氢原子时，W.sub.1为##STR5##以及其药学上可以接受的酸加成盐，具有抗炎，镇痛和消化道溃疡抑制活性。

  公开号：

  US04585869A1

文献信息

• 3-Aminoindazole derivatives
  申请人：Asahi, Kasei, Kogyo, Kabushiki, Kaisha

  公开号：US04474964A1

  公开（公告）日：1984-10-02

  A compound of the formula (I): ##STR1## wherein W.sub.1 is a hydrogen atom or a ##STR2## group wherein Y is a C.sub.1-6 alkylene group or a C.sub.1-6 alkylene group having a C.sub.1-6 alkyl group substituent; and R.sub.1 and R.sub.2 each independently is a hydrogen atom or a C.sub.1-6 alkyl group and R.sub.1 and R.sub.2 may form a C.sub.4-6 heterocyclic ring or a nitrogen-containing C.sub.4-6 heterocyclic ring together with the adjacent nitrogen atom and the C.sub.4-6 heterocyclic rings may have at least one C.sub.1-6 alkyl group, hydroxyl group or halogen atom; W.sub.2 is a hydrogen atom or a ##STR3## group wherein Z is a C.sub.1-6 alkylene group or a C.sub.1-6 alkylene group having a C.sub.1-6 alkyl group substituent; and R.sub.3 and R.sub.4 each independently is a hydrogen atom or a C.sub.1-6 alkyl group and R.sub.3 and R.sub.4 may form a C.sub.4-6 heterocyclic ring or a nitrogen-containing C.sub.4-6 heterocyclic ring together with the adjacent nitrogen atom and the C.sub.4-6 heterocyclic rings may have at least one C.sub.1-6 alkyl group, hydroxyl group or halogen atom; when W.sub.1 is a hydrogen atom, W.sub.2 is the ##STR4## group; and when W.sub.2 is a hydrogen atom, W.sub.1 is the ##STR5## group; and the pharmaceutically acceptable acid addition salt thereof having antiinflammatory, analgesic and digestive tract ulcer suppressing activity.

  化合物的式子(I)：##STR1## 其中W.sub.1是氢原子或##STR2##基团，其中Y是C.sub.1-6烷基链或具有C.sub.1-6烷基链取代基的C.sub.1-6烷基链; R.sub.1和R.sub.2各自独立地是氢原子或C.sub.1-6烷基链，且R.sub.1和R.sub.2可以与相邻的氮原子一起形成C.sub.4-6杂环环或含氮的C.sub.4-6杂环环，且C.sub.4-6杂环环可以具有至少一个C.sub.1-6烷基链、羟基或卤原子；W.sub.2是氢原子或##STR3##基团，其中Z是C.sub.1-6烷基链或具有C.sub.1-6烷基链取代基的C.sub.1-6烷基链; R.sub.3和R.sub.4各自独立地是氢原子或C.sub.1-6烷基链，且R.sub.3和R.sub.4可以与相邻的氮原子一起形成C.sub.4-6杂环环或含氮的C.sub.4-6杂环环，且C.sub.4-6杂环环可以具有至少一个C.sub.1-6烷基链、羟基或卤原子；当W.sub.1是氢原子时，W.sub.2是##STR4##基团; 当W.sub.2是氢原子时，W.sub.1是##STR5##基团; 以及其药学上可接受的酸盐，具有抗炎、镇痛和消化道溃疡抑制活性。
• 3-Aminoindazole derivatives and process for preparation thereof
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0049779A1

  公开（公告）日：1982-04-21

  A compound of the formula (I): wherein W, is a hydrogen atom or a group wherein Y is a C1-6 alkylene group or a C1-6 alkylene group having a C1-6 alkyl group substituent; and R, and R2 each independently is a hydrogen atom or a C1-6 alkyl group and R,, R2 and the adjacent nitrogen atom may form a C4-6 heterocyclic ring or a C4-6 heterocyclic ring containing an additional nitrogen atom and the C4-6 heterocyclic rings may have at least one C1-6 alkyl group, hydroxyl group or halogen atom; W2 is a hydrogen atom or a group wherein Z is a C1-6 alkylene group or a C1-6 alkylene group having a C1-6 alkyl group substituent; and R3 and R4 each independently is a hydrogen atom or a C1-6 alkyl group and R3, R4 and the adjacent nitrogen atom may form a C4-6 hetercyclic ring or a C4-6 heterocyclic ring containing an additional nitrogen atom and the C4-6 heterocyclic rings may have at least one C1-6 alkyl group, hydroxyl group or halogen atom; when W, is a hydrogen atom, W2 is the group; and when W2 is a hydrogen atom, W, is the group; and the pharmaceutically acceptable acid addition salt thereof.

  式 (I) 的化合物： 其中 W，是氢原子或 其中 Y 是 C1-6 亚烷基或具有 C1-6 烷基取代基的 C1-6 亚烷基；R 和 R2 各自独立地是氢原子或 C1-6 烷基，且 R、R2 和相邻的氮原子可形成 C4-6 杂环或含有额外氮原子的 C4-6 杂环，且 C4-6 杂环可具有至少一个 C1-6 烷基、羟基或卤素原子； W2 是氢原子或 其中 Z 为 C1-6 亚烷基或具有 C1-6 烷基取代基的 C1-6 亚烷基；以及 R3 和 R4 各自独立地为氢原子或 C1-6 烷基，且 R3、R4 和相邻氮原子可形成 C4-6 杂环或含有额外氮原子的 C4-6 杂环，且 C4-6 杂环可具有至少一个 C1-6 烷基、羟基或卤素原子； 当 W 是氢原子时，W2 是 基团；以及 当 W2 是氢原子时，W, 是基团；及 基团；及其药学上可接受的酸加成盐。
• US4474964A
  申请人：——

  公开号：US4474964A

  公开（公告）日：1984-10-02
• US4549023A
  申请人：——

  公开号：US4549023A

  公开（公告）日：1985-10-22
• US4585869A
  申请人：——

  公开号：US4585869A

  公开（公告）日：1986-04-29