PI3K-1-GM

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: PI3K-1-GM
• 英文别名: [(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-19-[5-(2-morpholin-4-yl-4-oxochromen-8-yl)pent-4-ynylamino]-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
• 化学式: C₄₆H₅₆N₄O₁₁
• 分子量: 840.971
• InChiKey: IHHXWOLBGAPCCE-FHZXOCNPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  61
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  205
• 氢给体数：
  4
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  1-(3-溴-2-羟基苯基)乙酮 在 吗啉 copper(l) iodide 、 四(三苯基膦)钯 、 TEA 、 potassium tert-butylate 、 potassium carbonate 、 溶剂黄146 、 三苯基膦 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 丙酮 、 苯 为溶剂， 反应 17.5h， 生成 PI3K-1-GM
  参考文献：
  名称：

  LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family

  摘要：

  Several LY294002-GM heterodimers were synthesized with the intent of modulating their activity in the presence of hsp90 and thereby creating selective inhibitors of PI3K and PI3K-related family. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00099-3

文献信息

• ERYTHROPOIETIN: REMODELING AND GLYCOCONJUGATION OF ERYTHROPOIETIN
  申请人：DeFrees Shawn

  公开号：US20070042458A1

  公开（公告）日：2007-02-22

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• Factor IX: remodeling and glycoconjugation of factor IX
  申请人：DeFrees Shawn

  公开号：US20080305991A1

  公开（公告）日：2008-12-11

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• Glycopegylation methods and proteins/peptides produced by the methods
  申请人：DeFrees Shawn

  公开号：US20090093399A1

  公开（公告）日：2009-04-09

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• GLUCOSAMINE NUCLEOTIDE SUGARS
  申请人：DeFrees Shawn

  公开号：US20090137763A1

  公开（公告）日：2009-05-28

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• GLYCOPEGYLATION METHODS AND PROTEINS/PEPTIDES PRODUCED BY THE METHODS
  申请人：DeFrees Shawn

  公开号：US20100048456A1

  公开（公告）日：2010-02-25

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.