N-phenethyl-3,3-di(4-pyridylmethyl)-2-indolinone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-phenethyl-3,3-di(4-pyridylmethyl)-2-indolinone
• 英文别名: 1-(2-Phenylethyl)-3,3-bis(pyridin-4-ylmethyl)indol-2-one
• 化学式: C₂₈H₂₅N₃O
• 分子量: 419.526
• InChiKey: BWUUWERSCMBCHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  46.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-phenethyl-indolin-2-one 、 4-氯甲基吡啶盐酸盐 在 potassium fluoride on basic alumina 作用下， 反应 0.07h， 以88%的产率得到N-phenethyl-3,3-di(4-pyridylmethyl)-2-indolinone
  参考文献：
  名称：

  Microwave-Assisted Rapid Synthesis of Neurotransmitter Release Enhancer Linopiridine and Its New Analogues

  摘要：

  A neurotransmitter release enhancer linopiridine and its new analogues have been synthesized rapidly in yields from the 1:2 coupling of oxiindole with 4-picolyl chloride hydrochloride on the surface of basic alumina doped with 37% KF under microwave irradiation in solvent-free conditions.

  DOI：

  10.1081/scc-120023425

文献信息

• Microwave-Assisted Rapid Synthesis of Neurotransmitter Release Enhancer Linopiridine and Its New Analogues
  作者：J. S. Yadav、B. V. S. Reddy

  DOI：10.1081/scc-120023425

  日期：2003.9

  A neurotransmitter release enhancer linopiridine and its new analogues have been synthesized rapidly in yields from the 1:2 coupling of oxiindole with 4-picolyl chloride hydrochloride on the surface of basic alumina doped with 37% KF under microwave irradiation in solvent-free conditions.