(1-苯基环丙基)甲胺盐酸盐 | 935-43-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (1-苯基环丙基)甲胺盐酸盐
• 英文名称: (1-phenylcyclopropyl)methylamine hydrochloride
• 英文别名: (Phenylcyclopropyl)methylamine Hydrochloride；(1-phenylcyclopropyl)methanamine;hydrochloride
• CAS: 935-43-3
• 化学式: C₁₀H₁₃N*ClH
• 分子量: 183.681
• InChiKey: SFMJEPXECDDEHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

安全信息

• 海关编码：
  2921499090
• 包装等级：
  III
• 危险类别：
  6.1
• 危险性防范说明：
  P301+P310,P305+P351+P338
• 危险品运输编号：
  2811
• 危险性描述：
  H301,H319

反应信息

• 作为反应物：
  描述：

  (1-苯基环丙基)甲胺盐酸盐 在 N-Boc-L-缬氨酸 、 sodium 2,2,2-trifluoroacetate 、 palladium diacetate 、 三乙胺 、 silver carbonate 作用下， 以 二氯甲烷 、 叔丁醇 为溶剂， 反应 18.08h， 生成 1,1,1-trifluoro-N-((1-phenyl-2-(p-tolyl)cyclopropyl)methyl)methanesulfonamide
  参考文献：
  名称：

  Palladium(II)-Catalyzed Highly Enantioselective C–H Arylation of Cyclopropylmethylamines

  摘要：

  C-H arylation via a Pd(II)/Pd(IV) catalytic cycle has been one of the most extensively studied C-H activation reactions since the 1990s. Despite the rapid development of this reaction in the past two decades, an enantioselective version has not been reported to date. Herein, we report a Pd(II)-catalyzed highly enantioselective (up to 99.5% ee) arylation of cyclopropyl C-H bonds with aryl iodides using mono-N-protected amino acid (MPAA) ligands, providing a new route for the preparation of chiral cis-aryl-cyclopropylmethylamines. The enantiocontrol is also shown to override the diastereoselectivity of chiral substrates.

  DOI：

  10.1021/ja512529e
• 作为产物：
  描述：

  1-苯基环丙甲胺 在 ammonium hydroxide 、 氯化亚砜 、 硼烷四氢呋喃络合物 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 (1-苯基环丙基)甲胺盐酸盐
  参考文献：
  名称：

  Palladium(II)-Catalyzed Highly Enantioselective C–H Arylation of Cyclopropylmethylamines

  摘要：

  C-H arylation via a Pd(II)/Pd(IV) catalytic cycle has been one of the most extensively studied C-H activation reactions since the 1990s. Despite the rapid development of this reaction in the past two decades, an enantioselective version has not been reported to date. Herein, we report a Pd(II)-catalyzed highly enantioselective (up to 99.5% ee) arylation of cyclopropyl C-H bonds with aryl iodides using mono-N-protected amino acid (MPAA) ligands, providing a new route for the preparation of chiral cis-aryl-cyclopropylmethylamines. The enantiocontrol is also shown to override the diastereoselectivity of chiral substrates.

  DOI：

  10.1021/ja512529e

文献信息

• INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME
  申请人：University Health Network

  公开号：US20140371202A1

  公开（公告）日：2014-12-18

  The present teaching provide indazole compounds represented by Structural Formulae (I) or (I′) or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof as protein kinase inhibitors, such as TTK protein kinase, polo-like kinase 4 (PLK4) and Aurora kinases having anticancer activity against breast cancer cells, colon cancer cells, and ovarian cancer cells.

  本教学提供由结构式（I）或（I'）所代表的吲唑化合物或其药学上可接受的盐。还描述了制备药物组合物和使用方法，作为蛋白激酶抑制剂，例如TTK蛋白激酶，极化样激酶4（PLK4）和极化激酶，对乳腺癌细胞，结肠癌细胞和卵巢癌细胞具有抗癌活性。
• EP3466962
  申请人：——

  公开号：——

  公开（公告）日：——
• C-Terminal Modifications of Histidyl-<i>N</i>-benzylglycinamides To Give Improved Inhibition of Ras Farnesyltransferase, Cellular Activity, and Anticancer Activity in Mice
  作者：Dennis J. McNamara、Ellen Dobrusin、Daniele M. Leonard、Kevon R. Shuler、James S. Kaltenbronn、John Quin、Scott Bur、Charles E. Thomas、Annette M. Doherty、Jeffrey D. Scholten、Karen K. Zimmerman、Barbara S. Gibbs、Richard C. Gowan、Michael P. Latash、Wilbur R. Leopold、Sally A. Przybranowski、Judith S. Sebolt-Leopold

  DOI：10.1021/jm970470c

  日期：1997.10.1
• CYCLOALKYL INHIBITORS OF PROTEIN FARNESYLTRANSFERASE
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0951471A1

  公开（公告）日：1999-10-27
• US6281194B1
  申请人：——

  公开号：US6281194B1

  公开（公告）日：2001-08-28