(1R,6S)-6-氨基-3-环己烯-1-羧酸盐酸盐(1:1) | 57266-56-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (1R,6S)-6-氨基-3-环己烯-1-羧酸盐酸盐(1:1)
• 英文名称: cis-6-Amino-3-cyclohexene-1-carboxylic acid hydrochloride
• 英文别名: (1R,6S)-6-aminocyclohex-3-ene-1-carboxylic acid;hydrochloride
• CAS: 57266-56-5
• 化学式: C7H12ClNO2
• 分子量: 177.63
• InChiKey: HZJHDHWPTTVQSN-IBTYICNHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.79
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  63.3
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302

文献信息

• [EN] FEM1B PROTEIN BINDING AGENTS AND USES THEREOF<br/>[FR] AGENTS SE LIANT À LA PROTÉINE FEM1B ET UTILISATIONS ASSOCIÉES
  申请人：UNIV CALIFORNIA

  公开号：WO2021183431A1

  公开（公告）日：2021-09-16

  Disclosed herein, inter alia, are compounds for binding FEMIB protein and uses thereof. In an aspect, provided herein is a pharmaceutical composition including a compound as described herein and a pharmaceutically acceptable excipient.

  本文披露了用于结合FEMIB蛋白的化合物及其用途。在一个方面，本文提供了一种包括本文描述的化合物和药用可接受的赋形剂的药物组合物。
• [EN] COMPOSITIONS AND METHODS RELATING TO SALTS OF SPECIALIZED PRO-RESOLVING MEDIATORS OF INFLAMMATION<br/>[FR] COMPOSITIONS ET PROCÉDÉS RELATIFS À DES SELS DE MÉDIATEURS SPÉCIALISÉS DE PRO-RÉSOLUTION D'INFLAMMATION
  申请人：THETIS PHARMACEUTICALS LLC

  公开号：WO2017210604A1

  公开（公告）日：2017-12-07

  The present invention relates to compounds of Formulas I-IV, which are salts of special lipid mediators of inflammation, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both.

  本发明涉及公式I-IV的化合物，它们是炎症特殊脂质介质的盐，包括含有它们的组合物，并且在治疗由慢性或过度炎症或两者都特征的各种疾病和障碍中使用它们的方法。
• Compositions and methods relating to salts of specialized pro-resolving mediators
  申请人：Thetis Pharmaceuticals LLC

  公开号：US10130719B2

  公开（公告）日：2018-11-20

  The present invention relates to compounds which are salts of specialized pro-resolving mediators (referred to herein as “SPMs”) which include lipoxins, resolvins, protectins, and their aspirin-triggered counterparts. The SPM salts described here contain at least one or two SPM molecules ionically bound to at least one basic function that is provided by a scaffold moiety as described herein, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both.

  本发明涉及的化合物是特异性促溶解介质（本文称为 "SPMs"）的盐，其中包括脂质素、溶血素、保护素及其阿司匹林触发的对应物。本文所述的 SPM 盐含有至少一个或两个与本文所述的支架分子提供的至少一种基本功能离子结合的 SPM 分子、含有相同成分的组合物以及使用相同成分治疗以慢性或过度炎症为特征的各种疾病和失调或两者兼而有之的方法。
• Compositions and methods for modulating protease activity
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US11124498B2

  公开（公告）日：2021-09-21

  Disclosed herein, inter alia, are compositions for modulating protease activity and treating cancer.

  本文特别披露了用于调节蛋白酶活性和治疗癌症的组合物。
• P38 map kinase inhibitors
  申请人：City of Hope

  公开号：US11225665B2

  公开（公告）日：2022-01-18

  Provided herein, inter alia, are p38 mitogen-activated protein kinase inhibitors and methods of treating cancer using p38 mitogen-activated protein kinase inhibitors.

  本文特别提供了p38丝裂原活化蛋白激酶抑制剂和使用p38丝裂原活化蛋白激酶抑制剂治疗癌症的方法。