(2,4-二氯苯基)磷酸二乙酯 | 3279-62-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (2,4-二氯苯基)磷酸二乙酯
• 英文名称: Dichlorofenoxon
• 英文别名: phosphoric acid diethyl ester-(2,4-dichloro-phenyl ester)；Phosphorsaeure-diaethylester-(2,4-dichlor-phenylester)；Diethyl-(2,4-dichlor-phenyl)-phosphat；Diethyl 2,4-dichlorophenyl phosphate；(2,4-dichlorophenyl) diethyl phosphate
• CAS: 3279-62-7
• 化学式: C₁₀H₁₃Cl₂O₄P
• 分子量: 299.091
• InChiKey: TVZVEGZSJDAAKQ-UHFFFAOYSA-N

物化性质

• 沸点：
  142-146 °C(Press: 0.2 Torr)
• 密度：
  1.320 g/cm3(Temp: 15 °C)
• 保留指数：
  1837

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2919900090

反应信息

• 作为反应物：
  描述：

  (2,4-二氯苯基)磷酸二乙酯 在 盐酸 、 sodium 作用下， 生成 5-氯-2-羟基苯基膦酸二乙酯
  参考文献：
  名称：

  1,3-carbanionische umlagerungen：Reaktionenvonphosphorsäure- o -haloarylestern mit metallen zuarylphosphonsäurederivaten

  摘要：

  磷酸的邻溴代芳基酯与镁反应，通过中间体格利雅（Grignard）化合物生成芳烃膦酸衍生物。如果将钠用作金属，则在邻氯芳基酯的情况下可以实现类似的金属化重排过程。2,4- Dibromoaryl酯是通过镁区域专一在攻击Ò位上。

  DOI：

  10.1016/s0022-328x(00)99340-9
• 作为产物：
  描述：

  除线磷 在 溴 作用下， 以 乙腈 为溶剂， 生成 (2,4-二氯苯基)磷酸二乙酯
  参考文献：
  名称：

  Oxidation of organophosphorus pesticides for the sensitive detection by a cholinesterase-based biosensor

  摘要：

  A potentiometric flow injection-type biosensor developed in our laboratory was used for the determination of organophosphorus pesticides (OPs). The principle of the biosensor is that the degree of inhibition of a sensor enzyme by an OP is dependent on the concentration of the pesticide. The sensor system consisted of a reactor with acetylcholinesterase (AChE) immobilized on a controlled pore glass and a detector with a tubular H+-selective membrane electrode. In order to examine the possibility of enhancing the sensitivity of the sensor by converting OPs to oxidized forms (stronger inhibitors), a comparison of the degree of enzyme inhibition by OPs at 10(-6) M before and after their oxidation was made. All of the ten pesticides tested exhibited greater inhibitory power toward the sensor enzyme following oxidation. All of the oxidized pesticides at 10(-6) M inhibited the sensor enzyme to a considerable degree, demonstrating the utility of the developed method for the class-specific determination of OPs. A calibration curve for diazinon, over the concentration range of 10(-11)-10(-4) M, was obtained. The lower detection limit was 2 x 10(-10) M. Treatment of the inhibited enzyme with pyridine-2-aldoxime restored the enzyme to near full activity, allowing repeated use of the sensor. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0045-6535(01)00005-4

文献信息

• Phosphorylation of Phenols with Diethyl Chlorophosphonate on the Surface of Magnesia
  作者：B. Kaboudin

  DOI：10.1039/a900183b

  日期：——

  Phosphorylation of phenols with diethyl chlorophosphonate on the surface of magnesia is an easy, rapid, safe and high-yielding reaction.

  氧化镁表面上的氯膦酸二乙酯使苯酚磷酸化是一种容易，快速，安全且高产的反应。
• Studies of organophosphorochloridates. Part V. Some derivatives of 2,4-dichlorophenyl and pentachlorophenyl phosphorodichloridates
  作者：R. J. W. Cremlyn、J. David、N. Kishore

  DOI：10.1039/p19720000583

  日期：——

  discussed. The phosphorodichloridates have been converted into some of the corresponding dialkyl phosphates, and NN′-dialkylphosphorodiamidates. The synthesis of 2,4-dichlorophenyl N-arylphosphoramidic chlorides and methyl 2,4-dichlorophenyl N-arylphosphoroamidates are also described. The pentachlorophenyl phosphorodichloridate derivatives were more fungicidal than those from 2,4-dichlorophenyl phosphorodichloridate

  讨论了2，4-二氯苯基和五氯苯基二氯化磷的制备和水解。二氯化磷已被转化为一些相应的磷酸二烷基酯和NN'-二烷基磷酸二酰胺酯。还描述了2，4-二氯苯基N-芳基磷酰氨基氯化物和2，4-二氯苯基N-芳基磷酰胺酸甲酯的合成。五氯苯基二氯磷酸酯衍生物比来自2，4-二氯苯基二氯磷酸酯的衍生物更具杀真菌作用。
• CH261807
  申请人：——

  公开号：——

  公开（公告）日：——
• HEINICKE J.; BOEHLE I.; TZSCHACH A., J. ORGANOMET. CHEM., 317,(1986) N 1, 11-21
  作者：HEINICKE J.、 BOEHLE I.、 TZSCHACH A.

  DOI：——

  日期：——