(2,4-二氯苯基)苯甲酸酯 | 7396-91-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 中文名称: (2,4-二氯苯基)苯甲酸酯
• 英文名称: Benzoesaeure-<2,4-dichlor-phenylester>
• 英文别名: 2,4-dichlorophenyl benzoate；(2,4-Dichlorophenyl) benzoate
• CAS: 7396-91-0
• 化学式: C₁₃H₈Cl₂O₂
• 分子量: 267.111
• InChiKey: UNNUESFABWIRHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2,4-二氯苯基)苯甲酸酯 在 N-甲基吡咯烷酮 、 potassium carbonate 、 苯硫酚 作用下， 反应 0.25h， 以74%的产率得到2,4-二氯酚
  参考文献：
  名称：

  Selective Deprotection of Aryl Acetates, Benzoates, Pivalates, and Tosylates under Nonhydrolytic and Virtually Neutral Conditions

  摘要：

  DOI：

  10.1021/jo990780y
• 作为产物：
  描述：

  2,6-二氯-3-羟基苯甲醛 在 氢氧化钾 、 sodium hydroxide 作用下， 生成 (2,4-二氯苯基)苯甲酸酯
  参考文献：
  名称：

  Lock, Monatshefte fur Chemie, 1930, vol. 55, p. 307,311

  摘要：

  DOI：

文献信息

• Easily Prepared Azopyridines As Potent and Recyclable Reagents for Facile Esterification Reactions. An Efficient Modified Mitsunobu Reaction
  作者：Nasser Iranpoor、Habib Firouzabadi、Dariush Khalili、Somayeh Motevalli

  DOI：10.1021/jo8000782

  日期：2008.7.1

  class of electron-deficient reagents for Mitsunobu esterification reactions. Among these compounds, 4,4′-azopyridine was found to be the most suitable one for esterification and thioesterification reactions. This new reagent promises to provide general and complementary solutions for separation problems in Mitsunobu reactions without restricting the reaction scope and facilitates the isolation of its

  研究了2,2'-，3,3'-和4,4'-偶氮吡啶（azpy）及其烷基吡啶鎓离子液体，作为用于Mitsunobu酯化反应的新型缺电子试剂。在这些化合物中，发现4,4'-偶氮吡啶是最适合酯化和硫酯化反应的化合物。这种新试剂有望为Mitsunobu反应中的分离问题提供通用和补充的解决方案，而不会限制反应范围，并有助于分离其肼副产物。吡啶肼副产物可通过氧化反应简单地再循环至其偶氮吡啶。
• 5,5′-Dimethyl-3,3′-azoisoxazole as a new heterogeneous azo reagent for esterification of phenols and selective esterification of benzylic alcohols under Mitsunobu conditions
  作者：Nasser Iranpoor、Habib Firouzabadi、Dariush Khalili

  DOI：10.1039/c004357e

  日期：——

  3′-azoisoxazole is used as a new efficient heterogeneous azo reagent for the highly selective esterification of primary and secondary benzylic alcohols and phenols with aliphatic and aromatic carboxylic acids via Mitsunobu protocols. The reaction is highly selective for primary benzylic alcohols versus secondary ones, aliphatic alcohols and also phenols. The isoxazole hydrazine byproduct can be simply isolated

  5,5'-二甲基-3,3'-偶氮异恶唑通过Mitsunobu协议，它用作新型高效的异质偶氮试剂，用于伯和仲苄醇和酚与脂肪族和芳香族羧酸的高选择性酯化。该反应对伯苄醇与仲醇，脂族醇以及酚的选择性很高。这异恶唑肼 副产物可以简单地通过过滤分离，并循环到其中 偶氮异恶唑 通过氧化。
• Copper-Catalyzed Regioselective Sila-acylation and Sila-imination of Allenes Using Esters and Nitriles
  作者：Tetsuaki Fujihara、Katsushi Suda、Yuki Matsuda、Tatsuya Yamaguchi

  DOI：10.1055/a-1648-7154

  日期：2022.2

  presence of a copper catalyst using PhMe2Si-B(pin) and esters as the silyl and acyl sources, respectively. β-Silyl-β,γ-unsaturated ketones are obtained regioselectively in good to high yields. The sila-imination of allenes is also achieved using nitriles as electrophiles. Exposure of the reaction mixture to air results in the production of cyclic silyl peroxides.

  丙二烯的硅烷酰化是在铜催化剂存在下使用 PhMe2Si-B(pin) 和酯分别作为甲硅烷基和酰基来源进行的。β-甲硅烷基-β,γ-不饱和酮以良好到高产率的区域选择性获得。使用腈作为亲电试剂也可以实现丙二烯的硅烷化。将反应混合物暴露在空气中会产生环状过氧化甲硅烷。
• NHC/Iron cooperative catalysis: aerobic oxidative esterification of aldehydes with phenols
  作者：R. Sudarshan Reddy、João N. Rosa、Luís F. Veiros、Stephen Caddick、Pedro M. P. Gois

  DOI：10.1039/c1ob05151b

  日期：——

  An NHC/iron cooperative catalytic system mediates the aerobic oxidative esterification of aldehydes with phenols. The use of equimolar amounts of reactants led to good to excellent isolated yields of esters.

  NHC /铁协同催化系统介导醛与酚的需氧氧化酯化。等摩尔量的反应物的使用导致酯的良好至优异的分离产率。
• Green and Efficient Method for the Acylation of Amines and Phenols in the Presence of Hydrotalcite in Water
  作者：Ahmad Reza Massah、Mitra Toghyani、Batool Hojati Najafabadi

  DOI：10.3184/174751912x13460810792101

  日期：2012.10

  In this study a mild, efficient and environmentally friendly method has been developed for the synthesis of amides and esters in the presence of hydrotalcite in water at room temperature. Different types of amines and phenols have been used and in all cases the products were obtained in moderate to high yields after an easy work-up. This method follows the principles of green chemistry.

  本研究开发了一种温和、高效、环保的方法，用于在氢滑石存在下于室温水中合成酰胺和酯。该方法使用了不同类型的胺和酚，在所有情况下，经过简单的加工，都能获得中等到高产率的产品。该方法遵循绿色化学原则。