(2-丁基-苯氧基)-乙酸 | 102167-36-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (2-丁基-苯氧基)-乙酸
• 英文名称: (2-Butyl-phenoxy)-essigsaeure
• 英文别名: <2-Butyl-phenoxy>-essigsaeure；(2-butyl-phenoxy)-acetic acid；O-(2-Butyl-phenyl)-glykolsaeure；(O-Butylphenoxy)acetic acid；2-(2-butylphenoxy)acetic acid
• CAS: 102167-36-2
• 化学式: C₁₂H₁₆O₃
• 分子量: 208.257
• InChiKey: APIOACZJBZKBFB-UHFFFAOYSA-N

物化性质

• 熔点：
  105 °C
• 沸点：
  325.9±17.0 °C(Predicted)
• 密度：
  1.093±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-丁基-苯氧基)-乙酸 生成 (2-butyl-phenoxy)-acetic acid ethyl ester
  参考文献：
  名称：

  Kulkarni et al., Journal of the Karnatak University, 1957, vol. 2, p. 69,70, 76

  摘要：

  DOI：
• 作为产物：
  描述：

  2-丁-1-烯基-苯甲醚 在 氢氧化钾 、 palladium on activated charcoal 、 乙醇 、 氢碘酸 、 溶剂黄146 作用下， 生成 (2-丁基-苯氧基)-乙酸
  参考文献：
  名称：

  818.酸催化的烷基芳基醚的重排。第一部分。丁基苯醚与氯化铝的重排

  摘要：

  DOI：

  10.1039/jr9590004080

文献信息

• Peroxyacids, phenoxyacetate peracid precursors and perhydrolysis system
  申请人：The Clorox Company

  公开号：EP0267048A2

  公开（公告）日：1988-05-11

  A perhydrolysis system for in situ generation of peroxyacid characterised in that it comprises: a peroxyacid percursor including at least one α-substituted carbonyl moiety having the structure: wherein R is hydrogen or an alkyl with not more than 5 carbons and L is a group whose conjugate acid has a pKa in aqueous solution of from about 5 to about 13; and a source of peroxygen which will react with the peroxyacid precursor in aqueous solution to form a peroxyacid having the structure: is disclosed. Peroxyacids and peroxyacid precursors are also disclosed.

  一种原位生成过氧酸的过水解系统，其特征在于它包括 一种过氧酸前驱体，包括至少一个α-取代的羰基，其结构如下 其中 R 为氢或碳原子数不超过 5 个的烷基，L 为共轭酸在水溶液中的 pKa 为 5 至 13 的基团；以及 一种过氧源，它将与水溶液中的过氧酸前体反应，形成具有上述结构的过氧酸： 已公开。 还公开了过氧酸和过氧酸前体。
• Pigment epithelial detachment in the elderly
  作者：D. Pauleikhoff、D. Löffert、G. Spital、M. Radermacher、J. Dohrmann、A. Lommatzsch、A. Bird

  DOI：10.1007/s00417-002-0505-8

  日期：2002.7

  Background: A prospective analysis was performed to characterize the angiographic appearance, natural course and prognosis of serous pigment epithelial detachments (PEDs) in elderly patients. The aim was to differentiate PEDs according to their angiographic characteristics and to analyze the specific clinical, visual and morphologic course of the different PEDs. Methods: Fluorescein and indocyanine green angiography were performed in 10 1 consecutive patients (53-87 years; 63 female, 38 male) with clinical signs of serous PED and drusen. Results: Different types of serous PED were identified: polypoidal choroidal vasculopathy (PCV)-associated PED in 14 patients (13.9%), vascular PED in 72 (71.2%), and avascular PED in 15 (14.9%). All PEDs resulted initially in similar visual loss. Avascular PEDs were smaller than vascular PEDs, and the latter were smaller than PCV-PEDs. During follow-up these differences were always present, but all PEDs enlarged initially followed by regression. This course was associated in all PEDs with progressive visual loss, accompanied by the development of RPE atrophy in avascular PEDs or disciform scars or RPE tears in the two other types. Conclusion: Despite different associations, all PEDs have a similar clinical course with respect to visual loss and enlargement or regression. This is compatible with the proposed common pathogenetic background with a hydrophobic barrier in Bruch's membrane causing fluid resulting from RPE pumping activity to accumulate between the pigment epithelium and Bruch's membrane.
• HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS
  申请人：ZENECA LIMITED

  公开号：EP0690847A1

  公开（公告）日：1996-01-10
• SUBSTITUTED 1,3,5-TRIAZINES AND PYRIMIDINES AS ABCA-1 ELEVATING COMPOUNDS AGAINST CORONARY ARTERY DISEASE OR ATHEROSCLEROSIS
  申请人：CV THERAPEUTICS, INC.

  公开号：EP1341773A2

  公开（公告）日：2003-09-10
• METHOD OF OLIGONUCLEOTIDE LABELING USING CYCLOADDITION REACTION
  申请人：Chemgenes Corporation

  公开号：EP2427573A2

  公开（公告）日：2012-03-14

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