(2-丁基环丙基)硼酸 | 190187-98-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 硼酸衍生物
• 中文名称: (2-丁基环丙基)硼酸
• 英文名称: trans-2-butylcyclopropylboronic acid
• 英文别名: (2-Butylcyclopropyl)boronic acid
• CAS: 190187-98-5
• 化学式: C₇H₁₅BO₂
• 分子量: 142.006
• InChiKey: JGKUHIAOLUTHAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.04
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  ethyl (2Z)-4,4,4-trifluoro-3-iodobut-2-enoate 、 (2-丁基环丙基)硼酸 在 bis-triphenylphosphine-palladium(II) chloride potassium phosphate 作用下， 以 甲苯 为溶剂， 反应 8.0h， 以91%的产率得到ethyl (E)-3-trans-n-butylcyclopropyl-4,4,4-trifluoro-2-butenoate
  参考文献：
  名称：

  Facile access to stereodefined dienoates and cyclopropylenoates containing a trifluoromethyl group

  摘要：

  Ethyl (2E,4E)-3-trifluoromethyl-2,4-dienoates 1a-e and ethyl (E)-3-trans-alkylcyclopropyl-4,4,4-trifluoro-2-butenoates 2a-e were prepared from the tratis-alkenylboronic acids 3a-e and the trans-cyclopropylboronic acids 4a-e with ethyl (Z)-3-iodo-4,4,4-trifluoro-2-butenoate (5) by the Suzuki cross-coupling reaction in high yields (88-95%). The configurations of both 3a-e or 4a-e and 5 were retained in the reaction. (C) 2003 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/s0022-1139(03)00192-1

文献信息

• Facile access to stereodefined dienoates and cyclopropylenoates containing a trifluoromethyl group
  作者：Ping-An Wang、Min-Zhi Deng、Rui-Qi Pan、Sheng-Yong Zhang

  DOI：10.1016/s0022-1139(03)00192-1

  日期：2003.11

  Ethyl (2E,4E)-3-trifluoromethyl-2,4-dienoates 1a-e and ethyl (E)-3-trans-alkylcyclopropyl-4,4,4-trifluoro-2-butenoates 2a-e were prepared from the tratis-alkenylboronic acids 3a-e and the trans-cyclopropylboronic acids 4a-e with ethyl (Z)-3-iodo-4,4,4-trifluoro-2-butenoate (5) by the Suzuki cross-coupling reaction in high yields (88-95%). The configurations of both 3a-e or 4a-e and 5 were retained in the reaction. (C) 2003 Elsevier B.V. All rights reserved.