3-Phenanthrylsulfat | 96794-36-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 3-Phenanthrylsulfat
• 英文别名: 3-Phenanthryl hydrogen sulfate；phenanthren-3-yl hydrogen sulfate
• CAS: 96794-36-4
• 化学式: C₁₄H₁₀O₄S
• 分子量: 274.297
• InChiKey: DFCZQECVFFVKDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] AMPHIPHILIC COMPOUNDS WITH NEUROPROTECTIVE PROPERTIES<br/>[FR] COMPOSÉS AMPHIPHILES DOTÉ DE PROPRIÉTÉS NEUROPROTECTRICES
  申请人：USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I

  公开号：WO2016029888A1

  公开（公告）日：2016-03-03

  The present invention provides amphiphilic compounds with tetradecahydrophenanthrene skeleton and their enantiomers, exhibiting neuroprotective effects, their use as medicaments for treating neuropsychiatric disorders associated with an imbalance in glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post-traumatic stress disorder and diseases related to stress, anxiety, schizophrenia and psychotic disorders, pain, addiction, multiple sclerosis, epilepsy, glioma, and a pharmaceutical composition containing said compound.

  本发明提供了具有十四氢苯并骨架及其对映体的两性化合物，表现出神经保护作用，它们可用作治疗与谷氨酸能神经递质系统失衡相关的神经精神障碍的药物，如中枢神经系统缺血性损伤、神经退行性变化和中枢神经系统障碍、情感障碍、抑郁症、创伤后应激障碍以及与压力、焦虑、精神分裂症和精神障碍、疼痛、成瘾、多发性硬化、癫痫、胶质瘤有关的疾病，以及含有该化合物的药物组合物。
• 6-SUBSTITUTED ESTRADIOL DERIVATIVES FOR USE IN REMYELINATION OF NERVE AXONS
  申请人：Endece, LLC

  公开号：EP2688570B1

  公开（公告）日：2015-11-18
• NOVEL COMPOUNDS OF 11BETA-HYDROXY-STEROIDS FOR USE IN MITOCHONDRIA BIOGENESIS AND DISEASES ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION OR DEPLETION
  申请人：Sphaera Pharma Pvt. Ltd.

  公开号：EP2948152A2

  公开（公告）日：2015-12-02
• AMPHIPHILIC COMPOUNDS WITH NEUROPROTECTIVE PROPERTIES
  申请人：Ustav Organicke Chemie a Biochemie AV CR, v.v.i.

  公开号：EP3186267A1

  公开（公告）日：2017-07-05
• [EN] NOVEL COMPOUNDS OF 11BETA-HYDROXY-STEROIDS FOR USE IN MITOCHONDRIA BIOGENESIS AND DISEASES ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION OR DEPLETION<br/>[FR] NOUVEAUX COMPOSÉS DE 11BÊTA-HYDROXY-STÉROÏDES DESTINÉS À ÊTRE UTILISÉS UTILISATION DANS LA BIOGENÈSE DE MITOCHONDRIES ET LES MALADIES ASSOCIÉES AVEC LA DYSFONCTION OU LA DÉPLÉTION MITOCHONDRIALE
  申请人：SPHAERA PHARMA PRIVATE LTD

  公开号：WO2014115167A2

  公开（公告）日：2014-07-31

  The present invention provides novel compounds of 11β-hydroxy steroids and compositions and their application as pharmaceuticals for preventing or reversing injury to mitochondria, for treating or preventing diseases relating to mitochondrial dysfunction or depletion, and for inducing regeneration or restructuring of mitochondria as a means of treating diseases relating to abnormalities in mitochondrial structure and function in a human or animal subject. Also disclosed herein are methods for diagnosing injury to mitochondria and for diagnosing the success or failure of therapeutics designed to treat, prevent, or reverse injury to or depletion of mitochondria.