(2R)-2-[[(2R)-2-[[(2S)-2,6-二氨基己酰基]氨基]丙酰]氨基]丙酸 | 33755-56-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (2R)-2-[[(2R)-2-[[(2S)-2,6-二氨基己酰基]氨基]丙酰]氨基]丙酸
• 英文名称: Lys-D-Ala-D-Ala
• 英文别名: Lysyl-alanyl-alanine；(2R)-2-[[(2R)-2-[[(2S)-2,6-diaminohexanoyl]amino]propanoyl]amino]propanoic acid
• CAS: 33755-56-5
• 化学式: C₁₂H₂₄N₄O₄
• 分子量: 288.347
• InChiKey: FZIJIFCXUCZHOL-HLTSFMKQSA-N

物化性质

• 沸点：
  637.8±55.0 °C(Predicted)
• 密度：
  1.193±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.9
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  148
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Novel antibacterial agents
  申请人：Christensen G. Burton

  公开号：US20070134729A1

  公开（公告）日：2007-06-14

  This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

  本发明涉及一种新型多结合化合物（药剂），其为抗菌剂。该发明的多结合化合物由2-10个配体通过连接剂或连接剂共价连接而成，其中每个单价（即未连接的）配体具有与细胞壁生物合成和代谢中的酶、合成细菌细胞壁和/或细菌细胞表面的前体有结合能力，从而干扰细胞壁的合成和/或代谢。特别地，本发明的多结合化合物由2-10个配体通过连接剂或连接剂共价连接而成，其中每个配体具有能够结合青霉素结合蛋白、横向肽酶酶、横向肽酶酶底物、β-内酰胺酶、青霉素酶、头孢菌素酶、横向转移酶酶或横向转移酶酶底物的配体结构域。优选地，配体选自β-内酰胺类或糖肽类抗菌剂。
• Intermediate for preparing glycopeptide derivatives
  申请人：——

  公开号：US20040204346A1

  公开（公告）日：2004-10-14

  This invention provides compounds of the formula: 1 wherein A and B are as defined; and Fmoc is 9-fluorenylmethoxycarbonyl. Such compounds are useful as intermediates for preparing glycopeptide derivatives which are useful as antibiotics.

  该发明提供了以下式子的化合物：1其中A和B的定义如上；Fmoc是9-芴甲氧羰基。这些化合物可用作制备糖肽衍生物的中间体，这些糖肽衍生物可用作抗生素。
• Glycopeptide derivatives and pharmaceutical compositions containing the same
  申请人：——

  公开号：US20030060598A1

  公开（公告）日：2003-03-27

  Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —R a —Y—R b —(Z) x where R a , R b , Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.

  本发明涉及一种含有至少一个配基的糖肽衍生物化合物，其配基的公式如下：—Ra—Y—Rb—(Z)x，其中Ra、Rb、Y、Z和x的定义如上所述，并且包含这种糖肽衍生物的药物组合物。所述的糖肽衍生物可用作抗菌剂。
• NOVEL ANTIBACTERIAL AGENTS
  申请人：Chen Qi-Qi

  公开号：US20050171010A1

  公开（公告）日：2005-08-04

  Novel antibacterial agents that act as multibinding agents are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to a transglycosylase enzyme substrate thereby modulating the biological processes/functions thereof.

  本发明揭示了一种作为多重结合剂的新型抗菌剂。该发明的化合物包括2-10个共价连接的配体，每个配体都能够结合到转醣基酶（transglycosylase）酶底物上，从而调节其生物过程/功能。
• GLYCOPEPTIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
  申请人：Judice J. Kevin

  公开号：US20090215982A1

  公开（公告）日：2009-08-27

  Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —R a —Y—R b -(Z) x where R a , R b , Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.

  本发明涉及具有至少一个以下式子的取代基的糖肽化合物衍生物：—Ra—Y—Rb-(Z)x，其中Ra、Rb、Y、Z和x如定义所述，并且含有这种糖肽衍生物的药物组合物。所述的糖肽衍生物可用作抗菌剂。