岩黄连碱 | 83218-34-2

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 中文名称: 岩黄连碱
• 中文别名: 去氢紫堇碱；脱氢卡维丁；脱水卡维丁
• 英文名称: Benzo(a)-1,3-benzodioxolo(4,5-g)quinolizinium, 8,9-dimethoxy-6-methyl-
• 英文别名: 16,17-dimethoxy-12-methyl-5,7-dioxa-1-azoniapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),9,11,14,16,18,20-nonaene
• CAS: 83218-34-2
• 化学式: C21H18NO4+
• 分子量: 348.4
• InChiKey: TWSZDJCOYVYRGM-UHFFFAOYSA-N

物化性质

• 溶解度：
  溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  41
• 氢给体数：
  0
• 氢受体数：
  4

制备方法与用途

化学性质
山奈酚-3-O-芸香糖苷为浅黄色针状结晶，可溶于甲醇、乙醇和DMSO等有机溶剂，来源于岩黄连。

用途
该化合物具有降血脂和活血化瘀的作用。

文献信息

• Methods for preparing dehydrocavidine, dehydroapocavidine or their composition, their use and medicinal compositon containing them
  申请人：Zhang Weidong

  公开号：US20070249650A1

  公开（公告）日：2007-10-25

  A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” ( Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.

  提供一种制备脱氢洋黄连碱、脱氢异洋黄连碱及其组合物的方法。该组合物首先通过溶剂萃取、水相有机萃取、结晶和重结晶等过程，从药用植物“岩黄连”（Corydalis saxicola Bunting）中分离和纯化季铵类生物碱成分，然后经过干燥以得到含有脱氢洋黄连碱和脱氢异洋黄连碱的组合物。必要时，可以通过色谱分离组合物或其粗提取物以得到脱氢洋黄连碱或脱氢异洋黄连碱。脱氢洋黄连碱、脱氢异洋黄连碱或其组合物可用于制造治疗病毒性肝炎、肝损伤、流感、艾滋病、肿瘤或心律不齐的药物。
• METHODS FOR PREPARING DEHYDROCAVIDINE, DEHYDROAPOCAVIDINE OR THEIR COMPOSITION, THEIR USE AND MEDICINAL COMPOSITON CONTAINING THEM
  申请人：Zhang Weidong

  公开号：US20100137350A9

  公开（公告）日：2010-06-03

  A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” ( Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.

  提供了一种制备脱氢阿匹卡啶、脱氢阿匹可卡啶及其相应组合物的方法。该组合物首先通过溶剂萃取、水相有机萃取、结晶和重结晶等过程从药用植物“燕黄连”（岩黄堇科黄堇属）中分离和纯化季铵类生物碱成分制备而成，然后干燥以获得含有脱氢阿匹卡啶和脱氢阿匹可卡啶的该组合物。必要时，该组合物或其粗提取物可以通过色谱分离获得脱氢阿匹卡啶或脱氢阿匹可卡啶。脱氢阿匹卡啶、脱氢阿匹可卡啶或其相应组合物可用于制造治疗病毒性肝炎、肝损伤、流感、艾滋病、肿瘤或心律失常的药物。
• US7732458B2
  申请人：——

  公开号：US7732458B2

  公开（公告）日：2010-06-08