(2S)-6-(2-羟基乙基)-2-(羟基甲基)-5,7-二甲基-2,3-二氢茚-1-酮 | 35964-50-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 中文名称: (2S)-6-(2-羟基乙基)-2-(羟基甲基)-5,7-二甲基-2,3-二氢茚-1-酮
• 英文名称: pterosin G
• 英文别名: (S)-2,3-Dihydro-6-(2-hydroxyethyl)-2-(hydroxymethyl)-5,7-dimethyl-1H-inden-1-one；(2S)-6-(2-hydroxyethyl)-2-(hydroxymethyl)-5,7-dimethyl-2,3-dihydroinden-1-one
• CAS: 35964-50-2
• 化学式: C₁₄H₁₈O₃
• 分子量: 234.295
• InChiKey: LGXRGPOUGZXSEB-NSHDSACASA-N

物化性质

• 沸点：
  458.1±45.0 °C(Predicted)
• 密度：
  1.192±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  在 硫酸 作用下， 以 水 为溶剂， 以0.78 mg的产率得到(2S)-6-(2-羟基乙基)-2-(羟基甲基)-5,7-二甲基-2,3-二氢茚-1-酮
  参考文献：
  名称：

  Ptesculentoside, a novel norsesquiterpene glucoside from the Australian bracken fern Pteridium esculentum

  摘要：

  A novel norsesquiterpene glucoside ptesculentoside has been isolated from the Australian bracken pteridium esculentum, together with the known bracken carcinogen ptaquiloside and lesser amounts of caudatoside. The structure of ptesculentoside is determined by analysis of 1D and 2D NMR spectra, and via its conversion into previously known pterosin G. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.02.032

文献信息

• USE OF PTEROSIN COMPOUNDS FOR TREATING DIABETES AND OBESITY
  申请人：Hsu Feng-Lin

  公开号：US20100190732A1

  公开（公告）日：2010-07-29

  This invention relates to the use of pterosin compounds of formula I for treating diabetes including type I and type II. Also disclosed is the use of the pterosin compounds for treating obesity.

  本发明涉及使用式I的翼龙素化合物治疗糖尿病，包括1型和2型糖尿病。还揭示了使用翼龙素化合物治疗肥胖症。
• US8633252B2
  申请人：——

  公开号：US8633252B2

  公开（公告）日：2014-01-21
• Ptesculentoside, a novel norsesquiterpene glucoside from the Australian bracken fern Pteridium esculentum
  作者：Mary T. Fletcher、Patrica Y. Hayes、Michael J. Somerville、James J. De Voss

  DOI：10.1016/j.tetlet.2010.02.032

  日期：2010.4

  A novel norsesquiterpene glucoside ptesculentoside has been isolated from the Australian bracken pteridium esculentum, together with the known bracken carcinogen ptaquiloside and lesser amounts of caudatoside. The structure of ptesculentoside is determined by analysis of 1D and 2D NMR spectra, and via its conversion into previously known pterosin G. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.