(2S,4S)-4-(二苯基膦基)-2-((二苯基膦基)甲基)-N-苯基吡咯烷-1-甲酰胺 | 74571-27-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (2S,4S)-4-(二苯基膦基)-2-((二苯基膦基)甲基)-N-苯基吡咯烷-1-甲酰胺
• 英文名称: (2S,4S)-4-(Diphenylphosphino)-2-<(diphenylphosphino)-methyl>-N-phenylcarbamoylpyrrolidine
• 英文别名: (2S,4S)-N-phenylaminocarbonyl-4-diphenylphosphino-2-diphenylphosphinomethylpyrrolidine；(2S,4S)-4-(Diphenylphosphino)-2-[(diphenylphosphino)methyl]-N-phenyl-1-pyrrolidinecarboxamide；(2S,4S)-4-diphenylphosphanyl-2-(diphenylphosphanylmethyl)-N-phenylpyrrolidine-1-carboxamide
• CAS: 74571-27-0
• 化学式: C₃₆H₃₄N₂OP₂
• 分子量: 572.626
• InChiKey: AAYSIAJWYYFANM-QGRQJHSQSA-N

物化性质

• 沸点：
  730.7±60.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  41
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (2S,4S)-(-)-4-二苯基膦基-2-(二苯基膦甲基)吡咯烷 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以76.2%的产率得到(2S,4S)-4-(二苯基膦基)-2-((二苯基膦基)甲基)-N-苯基吡咯烷-1-甲酰胺
  参考文献：
  名称：

  Asymmetric Reactions Catalyzed by Chiral Metal Complexes. XLV. Efficient Preparation of Optically Active (S)-(-)-3-Methyl-.GAMMA.-butyrolactone by Catalytic Asymmetric Hydrogenation Using Chiral N-Substituted Pyrrolidinebisphosphine Rhodium Complexes.

  摘要：

  (S)-(-)-2-甲基琥珀酰胺酸是一种良好的(S)-(-)-3-甲基-γ-丁内酯的前体，可通过(2S, 4S)-N-取代的-4-(二苯膦基)-2-[(二苯膦基)甲基]吡咯烷-铑配合物催化的2-亚甲基琥珀酰胺酸的均相不对称氢化制备。合成了多种N-取代的吡咯烷双膦配体，以寻找最佳配体并比较N-取代基的影响。

  DOI：

  10.1248/cpb.39.2706
• 作为试剂：
  描述：

  4,5-二氢-6-肟-咪唑并[4,5,1-jk][1]苯并氮杂卓-2,6,7(1H)-三酮 在 bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate 、 (2S,4S)-4-(二苯基膦基)-2-((二苯基膦基)甲基)-N-苯基吡咯烷-1-甲酰胺 氢气 作用下， 以 甲醇 、 水 为溶剂， 40.0 ℃ 、5.0 MPa 条件下， 反应 20.0h， 生成 C₁₁H₁₃N₃O₂ 、 C₁₁H₁₃N₃O₂
  参考文献：
  名称：

  EP1995248

  摘要：

  公开号：

文献信息

• N-carbamoyl-4-diphenylphosphino-2-diphenylphosphinomethylpyrrolidines(CAPP). Efficient new chiral ligands for asymmetric hydrogenation
  作者：Iwao Ojima、Noriko Yoda

  DOI：10.1016/s0040-4039(00)78836-8

  日期：1980.1

  N-(N′-substituted carbamoyl)-4-diphenylphosphino-2-diphenylphosphinomethylpyrrolidines (CAPP) was prepared, which exhibited excellent stereoselectivity in the asymmetric hydrogenation of α-acetamidocinnamic acid derivatives and itaconic acid as chiral ligand of the rhodium(I) catalyst.

  制备了一系列的N-（N'-取代的氨基甲酰基）-4-二苯基膦基-2-二苯基膦基甲基吡咯烷酮（CAPP），它们在作为铑的手性配体的α-乙酰氨基doc酰胺酸衍生物和衣康酸的不对称加氢中表现出优异的立体选择性。 I）催化剂。
• Asymmetric Reduction Method
  申请人：Matsumoto Yoshinori

  公开号：US20090043110A1

  公开（公告）日：2009-02-12

  The present invention is to provide a novel method for producing (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid which is useful as a therapeutic agent for diabetes. The present invention relates to a method for producing (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid, which is characterized in that 2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid is subjected to a catalytic reduction reaction in the presence of an asymmetric catalyst prepared from a pyrrolidinebisphosphine compound (I) represented by the following general formula (I): wherein, R 1 represents a linear or branched alkyl group having 1-10 carbon atoms, cycloalkyl group, aralkyl group or aryl group which may respectively have a substituent; and R 2 and R 3 independently represent an optionally substituted aryl group. The * mark in the pyrrolidine ring shows that the carbon atom at that position has the S configuration, and a rhodium compound.

  本发明旨在提供一种新的制备(2S)-2-苄基-3-(顺式-六氢-2-异吲哚基甲酰)丙酸的方法，该方法可用作糖尿病治疗剂。本发明涉及一种制备(2S)-2-苄基-3-(顺式-六氢-2-异吲哚基甲酰)丙酸的方法，其特征在于将2-苄基亚甲基-3-(顺式-六氢-2-异吲哚基甲酰)丙酸在不对称催化剂的存在下进行催化还原反应，该不对称催化剂由下式(I)表示的吡咯烷双膦化合物制备而成：其中，R1代表具有1-10个碳原子的线性或支链烷基、环烷基、芳基烷基或芳基，它们可以分别具有取代基；R2和R3独立地代表可选取代的芳基。吡咯烷环中的*标记表示该位置的碳原子具有S构型，还包括一种铑化合物。
• Enantioselective synthesis of 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-JK][1]-benzazepin-2[1H]-one and zilpaterol
  申请人：Almena-Perea Juan Jose

  公开号：US20100173892A1

  公开（公告）日：2010-07-08

  This invention relates to a process for the hydrogenation of a ketooxime to selectively form an aminoalcohol stereoisomer, and, in particular, to a process for the hydrogenation of 4,5-dihydro-imidazo[4,5,1-jk][1]benzazepin-2,6,7[1H]-trione-6-oxime or a salt thereof to selectively form a stereoisomer of 6-amino-7-hydroxy-4,5,6, 7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one or a salt thereof. This invention also relates to the use of the 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one hydrogenation product or a salt thereof to selectively make a stereoisomer of zilpaterol or a salt thereof, as well as the use of such a zilpaterol stereoisomer or salt in methods of treatment and medicaments for animals.

  本发明涉及一种氢化酮肟的方法，以选择性地形成氨基醇立体异构体，特别是涉及一种对4,5-二氢咪唑[4,5,1-jk][1]苯并氮杂环-2,6,7[1H]-三酮-6-肟或其盐进行氢化的方法，以选择性地形成6-氨基-7-羟基-4,5,6,7-四氢咪唑[4,5,1-jk][1]-苯并氮杂环-2[1H]-酮或其盐的立体异构体。本发明还涉及使用6-氨基-7-羟基-4,5,6,7-四氢咪唑[4,5,1-jk][1]-苯并氮杂环-2[1H]-酮氢化产物或其盐选择性地制备一种齐帕特罗尔的立体异构体或其盐，以及使用这种齐帕特罗尔立体异构体或其盐在动物治疗和药物中的方法。
• ASYMMETRIC REDUCTION METHOD
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：EP1978016A1

  公开（公告）日：2008-10-08

  The present invention is to provide a novel method for producing (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcar bonyl)propionic acid which is useful as a therapeutic agent for diabetes. The present invention relates to a method for producing (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarb onyl)propionic acid, which is characterized in that 2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propi onic acid is subjected to a catalytic reduction reaction in the presence of an asymmetric catalyst prepared from a pyrrolidinebisphosphine compound (I) represented by the following general formula (I): wherein, R1 represents a linear or branched alkyl group having 1-10 carbon atoms, cycloalkyl group, aralkyl group or aryl group which may respectively have a substituent; and R2 and R3 independently represent an optionally substituted aryl group. The * mark in the pyrrolidine ring shows that the carbon atom at that position has the S configuration, and a rhodium compound.

  本发明旨在提供一种生产(2S)-2-苄基-3-(顺式六氢-2-异吲哚啉基羰基)丙酸的新方法，该方法可用作糖尿病的治疗剂。本发明涉及一种生产(2S)-2-苄基-3-(顺式-六氢-2-异吲哚啉基羰基)丙酸的方法，其特征在于 2-亚苄基-3-(顺式-六氢-2-异吲哚啉基羰基)丙酸在由吡咯烷二膦化合物(I)制备的不对称催化剂存在下进行催化还原反应，吡咯烷二膦化合物(I)由以下通式(I)表示： 其中，R1 代表具有 1-10 个碳原子的直链或支链烷基、环烷基、芳烷基或芳基，可分别具有一个取代基；R2 和 R3 独立地代表任选取代的芳基。吡咯烷环中的 * 号表示该位置的碳原子具有 S 构型，是一种铑化合物。
• ENANTIOSELECTIVE SYNTHESIS OF 6-AMINO-7-HYDROXY-4, 5, 6, 7-TETRAHYDRO-IMIDAZO [4, 5, 1-JK][1]-BENZAZEPIN-2 [1H]-ONE AND ZILPATEROL
  申请人：Intervet International B.V.

  公开号：EP2109614B1

  公开（公告）日：2014-08-06