(3,5-二甲氧基苯基)三乙氧基硅烷 | 1428345-71-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (3,5-二甲氧基苯基)三乙氧基硅烷
• 英文名称: (3,5-dimethoxyphenyl)triethoxysilane
• 英文别名: (3,5-dimethoxyphenyl)-triethoxysilane
• CAS: 1428345-71-4
• 化学式: C₁₄H₂₄O₅Si
• 分子量: 300.427
• InChiKey: NVOKNYODZALBSH-UHFFFAOYSA-N

物化性质

• 沸点：
  334.9±32.0 °C(Predicted)
• 密度：
  1.04±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.96
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (3,5-二甲氧基苯基)三乙氧基硅烷 、 N,N-二甲基甲酰胺 在 碘化铵 、 potassium fluoride 、 copper(II) nitrate trihydrate 、 氧气 作用下， 反应 25.0h， 以85%的产率得到3,5-二甲氧基苯腈
  参考文献：
  名称：

  Copper-Mediated Transformation of Organosilanes to Nitriles with DMF and Ammonium Iodide

  摘要：

  Cyanation of aryl-, diaryldimethyl-, and styrylsilanes was developed for the first time under copper-mediated oxidative conditions using ammonium iodide and DMF as the combined source of nitrogen and carbon atom of the introduced cyano unit, respectively. The reaction was observed to proceed in a two-step process: initial conversion of organosilanes to their iodo intermediates and then cyanation. This method has a broad substrate scope with high functional group tolerance.

  DOI：

  10.1021/ol400659p

文献信息

• Copper-Mediated Transformation of Organosilanes to Nitriles with DMF and Ammonium Iodide
  作者：Zhen Wang、Sukbok Chang

  DOI：10.1021/ol400659p

  日期：2013.4.19

  Cyanation of aryl-, diaryldimethyl-, and styrylsilanes was developed for the first time under copper-mediated oxidative conditions using ammonium iodide and DMF as the combined source of nitrogen and carbon atom of the introduced cyano unit, respectively. The reaction was observed to proceed in a two-step process: initial conversion of organosilanes to their iodo intermediates and then cyanation. This method has a broad substrate scope with high functional group tolerance.