(3-Ethyl-2-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazono}-4-oxo-thiazolidin-5-yl)-acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-Ethyl-2-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazono}-4-oxo-thiazolidin-5-yl)-acetic acid
• 英文别名: {3-Ethyl-2-[(4-nitro-benzylidene)-hydrazono]-4-oxo-thiazolidin-5-yl}-acetic acid；2-[(2Z)-3-ethyl-2-[(E)-(4-nitrophenyl)methylidenehydrazinylidene]-4-oxo-1,3-thiazolidin-5-yl]acetic acid
• 化学式: C₁₄H₁₄N₄O₅S
• 分子量: 350.355
• InChiKey: HLTLMKSHAKIJEK-VFDNREJYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  153
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  对硝基苯甲醛 在 溶剂黄146 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 生成 (3-Ethyl-2-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazono}-4-oxo-thiazolidin-5-yl)-acetic acid
  参考文献：
  名称：

  Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity

  摘要：

  Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively, from thiosemicarbazide, in satisfactory yields. Then, the synthesized compounds were submitted to evaluation against host cells infected with Toxoplasma gondii. The present studies showed that thiosemicarbazones 2 and 4-thiazolidinone derivatives 3 were effective against intracellular T. gondii. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.03.048