(3-氨基环丁基)乙酸 | 1408076-40-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (3-氨基环丁基)乙酸
• 英文名称: (3-Aminocyclobutyl)acetic acid
• 英文别名: 2-(3-aminocyclobutyl)acetic acid
• CAS: 1408076-40-3
• 化学式: C₆H₁₁NO₂
• 分子量: 129.16
• InChiKey: JZOKIDHQIVAHON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same
  申请人：Fan Hong

  公开号：US20050147555A1

  公开（公告）日：2005-07-07

  Methods for the preparation of multivalent constructs for therapeutic and diagnostic applications are provided. More specifically, novel methods for preparing multivalent constructs comprising the formula A-B-C-D-E-B′-F for therapeutic and diagnostic applications are provided which use a novel linker D comprising, in various embodiments, a dicarboxylic acid derivative such as, e.g., a glutaric acid bis N-hydroxysuccinimidyl ester or a derivative therof; or a diamine derivative. The remaining components in the multivalent construct A-B-C-D-E-B′-F are defined as follows: A is a first peptide, B is a first branching group, C is an optional first spacer, E is an optional second spacer which may be the same as or different from said first spacer C, B′ is an optional second branching group which may be the same as or different from said first branching group B, and F is a second peptide which may be the same as or different from said first peptide A.

  提供了制备用于治疗和诊断应用的多价构建物的方法。更具体地，提供了用于制备多价构建物的新方法，其包括公式A-B-C-D-E-B'-F，其中使用了一种新的连接剂D，该连接剂D包括各种衍生物，例如戊二酸双N-羟基琥珀酰亚胺酯或其衍生物；或者是一种二胺衍生物。多价构建物A-B-C-D-E-B'-F中的其余组分定义如下：A是第一肽，B是第一分支基团，C是可选的第一间隔物，E是可选的第二间隔物，可以与第一间隔物C相同或不同，B'是可选的第二分支基团，可以与第一分支基团B相同或不同，而F是第二肽，可以与第一肽A相同或不同。
• Pyrazolo-pyrimidin-amino-cycloalkyl compounds and their therapeutic uses
  申请人：RAPT THERAPEUTICS, INC.

  公开号：US11046699B2

  公开（公告）日：2021-06-29

  Disclosed herein are pyrozolo-pyrimidin-amino-cycloalkyl compounds, analogs thereof, pharmaceutical compositions comprising thereof and therapeutic uses therefor.

  本文公开了吡唑嘧啶-氨基环烷基化合物、其类似物、包含这些化合物的药物组合物及其治疗用途。
• METHODS FOR PREPARING MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS
  申请人：BRACCO International B.V.

  公开号：EP1778299A2

  公开（公告）日：2007-05-02
• EP1778299A4
  申请人：——

  公开号：EP1778299A4

  公开（公告）日：2009-08-26
• US7666979B2
  申请人：——

  公开号：US7666979B2

  公开（公告）日：2010-02-23