(3R)-3,5-二羟基-3-甲基戊酸酯 | 1192-42-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: (3R)-3,5-二羟基-3-甲基戊酸酯
• 中文别名: 英卡膦酸二钠
• 英文名称: (R)-mevalonate
• 英文别名: mevalonate；(3R)-3,5-dihydroxy-3-methylpentanoate
• CAS: 1192-42-3
• 化学式: C₆H₁₁O₄
• 分子量: 147.151
• InChiKey: KJTLQQUUPVSXIM-ZCFIWIBFSA-M

物化性质

• 沸点：
  105-106 °C(Press: 5 Torr)
• 密度：
  1.266±0.06 g/cm3(Predicted)
• 碰撞截面：
  132.9 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  80.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2932209090

反应信息

• 作为反应物：
  描述：

  (3R)-3,5-二羟基-3-甲基戊酸酯 、 L-阿拉伯糖 以 乙酸乙酯 为溶剂， 反应 40.0h， 以to form mevalonolactone, and 700 μl of ethyl acetate的产率得到甲瓦龙酸内酯
  参考文献：
  名称：

  METHODS OF GENERATING PROTEIN VARIANTS

  摘要：

  本发明提供了设计和生成多肽变体的方法，这些变体与母体多肽相比具有改变的性质。本发明还提供了用于进行变体多肽设计的计算机程序产品。本发明还提供了编码酶变体的核酸，以及包含这些核酸的载体和宿主细胞。本发明还提供了变体酶；制备变体酶的方法；以及使用这些酶制备化合物的方法。

  公开号：

  US20080318292A1
• 作为产物：
  描述：

  D-甲瓦龙酸?酯 在 水 、 potassium hydroxide 、 盐酸 作用下， 反应 1.0h， 生成 (3R)-3,5-二羟基-3-甲基戊酸酯
  参考文献：
  名称：

  Identification of enzymes involved in the mevalonate pathway of Flavobacterium johnsoniae

  摘要：

  The mevalonate pathway is prevalent in eukaryotes, archaea, and a limited number of bacteria. This pathway yields the fundamental precursors for isoprenoid biosynthesis, i.e., isopentenyl diphosphate and dimethylally diphosphate. In the downstream part of the general eukaryote-type mevalonate pathway, mevalonate is converted into isopentenyl diphosphate by the sequential actions of mevalonate kinase, phosphomevalonate kinase, and diphosphomevalonte decarboxylase, while a partial lack of the putative genes of these enzymes is sometimes observed in archaeal and bacterial genomes. The absence of these genes has led to the recent discovery of modified mevalonate pathways. Therefore, we decided to investigate the mevalonate pathway of Flavobacterium johnsoniae, a bacterium of the phylum Bacter-oidetes, which is reported to lack the genes of mevalonate kinase and phosphomevalonate kinase. This study provides proof of the existence of the general mevalonate pathway in E johnsoniae, although the pathway involves the kinases that are distantly related to the known enzymes. (C) 2017 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bbrc.2017.04.120

文献信息

• Production of farnesol and geranylgeraniol
  申请人：Arkion Life Sciences LLC.

  公开号：US20040110257A1

  公开（公告）日：2004-06-10

  The invention provides a biological method of producing farnesol or geranylgeraniol.

  本发明提供了一种生物制备法用于生产芳樟醇或虫脂醇。
• Method of vitamin production
  申请人：DCV, Inc., d/b/a Bio-Technical Resources

  公开号：US20030125573A1

  公开（公告）日：2003-07-03

  The invention provides a method of producing &agr;-tocopherol and &agr;-tocopheryl esters. The method comprises using a biological system to produce farnesol or geranylgeraniol. Then, the farnesol or geranylgernaiol is chemically converted into &agr;-tocopherol or an &agr;-tocopheryl ester.

  本发明提供了一种生产α-生育酚和α-生育酚酯的方法。该方法包括使用生物系统生产法尼醇或戊二烯醇。然后，将法尼醇或戊二烯醇在化学上转化为α-生育酚或α-生育酚酯。
• METHODS OF GENERATING PROTEIN VARIANTS
  申请人：KEASLING JAY D.

  公开号：US20080318292A1

  公开（公告）日：2008-12-25

  The present invention provides methods of designing and generating polypeptide variants that have altered properties compared to a parent polypeptide. The present invention further provides a computer program product for carrying out the design of a variant polypeptide. The present invention further provides nucleic acids encoding enzyme variants, as well as vectors and host cells comprising the nucleic acids. The present invention further provides variant enzymes; methods of producing the variant enzymes; and methods of producing compounds using the enzymes.

  本发明提供了设计和生成多肽变体的方法，这些变体与母体多肽相比具有改变的性质。本发明还提供了用于进行变体多肽设计的计算机程序产品。本发明还提供了编码酶变体的核酸，以及包含这些核酸的载体和宿主细胞。本发明还提供了变体酶；制备变体酶的方法；以及使用这些酶制备化合物的方法。
• Production of Isoprenoids
  申请人：Millis R. James

  公开号：US20070231861A1

  公开（公告）日：2007-10-04

  The invention provides a biological method of producing isoprenoids.

  本发明提供了一种生物制备异戊二烯类化合物的方法。
• Combination Of Dehydroepiandrosterone Or Dehydroepiandrosterone-Sulfate With An Anticholinergic Bronchodilator For Treatment Of Asthma Or Chronic Obstructive Pulmonary Disease
  申请人：Robinson Cynthia B.

  公开号：US20080279789A1

  公开（公告）日：2008-11-13

  A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and/or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising an anticholinergic bronchodilator for the treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases.

  一种药物或兽医用组合物，包括第一活性成分，所述第一活性成分由去氢表雄酮和/或去氢表雄酮硫酸盐或其盐选出，以及第二活性成分，所述第二活性成分包括抗胆碱能支气管扩张剂，用于治疗哮喘、慢性阻塞性肺疾病或其他呼吸系统疾病。该组合物以各种配方和套装形式提供。该专利产品用于预防和治疗哮喘、慢性阻塞性肺疾病或其他呼吸系统疾病。