(4-乙氧基苯基)肼 | 39943-51-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (4-乙氧基苯基)肼
• 英文名称: 4-ethoxyphenyl hydrazine
• 英文别名: 4-ethoxyphenylhydrazine；(4-ethoxy-phenyl)-hydrazine；(4-Aethoxy-phenyl)-hydrazin；4-Hydrazino-phenol-aethylaether；4-Hydrazino-phenetol；p-ethoxyphenylhydrazine；(4-ethoxyphenyl)hydrazine
• CAS: 39943-51-6
• 化学式: C₈H₁₂N₂O
• mdl: MFCD12403348
• 分子量: 152.196
• InChiKey: LPOSDRDCHBRQLT-UHFFFAOYSA-N

物化性质

• 熔点：
  118-119 °C
• 沸点：
  290.5±23.0 °C(Predicted)
• 密度：
  1.114±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  47.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (4-乙氧基苯基)肼 在 二氯乙酸 、 硫酸二甲酯 作用下， 生成 (4-ethoxy-phenylhydrazono)-acetic acid amide
  参考文献：
  名称：

  Process of forming colored images by means of aryl hydrazones of glyoxylic acid amide

  摘要：

  公开号：

  US02449388A1
• 作为产物：
  描述：

  对乙氧基苯胺 在 盐酸 、 水 、 sodium nitrite 作用下， 生成 (4-乙氧基苯基)肼
  参考文献：
  名称：

  Stolz, Chemische Berichte, 1892, vol. 25, p. 1664

  摘要：

  DOI：

文献信息

• Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts
  申请人：SHANGHAI HYBRID-CHEM TECHNOLOGIES

  公开号：US20190152896A1

  公开（公告）日：2019-05-23

  The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

  本发明提供了一种连续流程，用于合成苯肼盐和取代苯肼盐。重氮化、还原、酸性水解和酸化与酸类创新地集成在一起。使用苯胺或取代苯胺的酸性液体、重氮化试剂、还原剂和酸类作为原料，通过合成过程获得苯肼衍生物盐，这是一个包括重氮化、还原、酸性水解和酸化的三步连续串联反应。所述的合成过程是一种集成解决方案，是在一个集成反应器中进行的。集成反应器的进料口连续填充原料。在集成反应器中，重氮化、还原、酸性水解和酸化被连续有序地进行，苯肼盐或取代苯肼盐在集成反应器的出口处获得，没有中断。总反应时间不超过20分钟。
• Unprecedented Direct Conversion of N-N and N=N bonds to N-(tert-Butyloxy)-carbamates
  作者：S. Chandrasekhar、Ch. Raji Reddy、R. Jagadeeshwar Rao

  DOI：10.1055/s-2001-17439

  日期：——

  For the first time a one step direct conversion of aromatic hydrazines and azo compounds to N-(tert-butoxycarbonyl) amines is achieved via reductive cleavage of N-N and N=N bonds using the inexpensive and safe hydride source polymethylhydrosiloxane (PMHS) and di-tert-butyl dicarbonate [(Boc)2O] in the presence of a catalytic amount of 10% Pd-C.

  首次通过使用廉价且安全的氢化物源聚甲基氢硅氧烷（PMHS）与二叔丁基二碳酸酯[（Boc）2O]，在10% Pd-C催化剂的催化作用下，实现了芳香肼和偶氮化合物通过还原断裂N-N与N=N键，一步直接转化为N-（叔丁氧羰基）胺。
• [EN] PREPARATION OF 3-AMINOALKYL-SUBSTITUTED INDOLE DERIVATIVES FROM PHENYLHYDRAZINES AND AMINOKETONES<br/>[FR] PREPARATION DE DERIVES D'INDOLE A SUBSTITUTION 3-AMINOALKYLE A PARTIR DE PHENYLHYDRAZINES ET D'AMINOCETONES
  申请人：SUVEN LIFE SCIENCES LTD

  公开号：WO2004041781A1

  公开（公告）日：2004-05-21

  The present invention relates to a process for the preparation of indole derivatives, particularly those, which are useful as pharmaceutical intermediates. The process involves formation of hydrazone derivative between a phenyl hydrazine and a ketone amine, followed by cyclisation to give desired 2,3-substituted indole derivative in the presence of acid catalyst.

  本发明涉及一种制备吲哚衍生物的方法，特别是那些作为药物中间体有用的衍生物。该方法涉及在酸催化剂存在下，通过苯基肼和酮胺之间的缩醛衍生物的形成，然后进行环化反应，得到所需的2,3-取代吲哚衍生物。
• Design and synthesis of new orally active inhibitors of human neutrophil elastase
  作者：K Ohmoto

  DOI：10.1016/s0968-0896(01)00007-4

  日期：2001.5

  To identify new orally active inhibitors, further modification of 1 (ONO-6818) was performed. Peptidic derivatives 4b, 4c and 4n showed more potent inhibitory activity than nonpeptidic derivatives 3a-c. As a result, a series of peptidic inhibitors, 4a-s and 5a-v, were discovered. Among these N-aryl derivatives 5a-g, 5i, 5m and 5o-v showed oral activity. Their oral activity showed good correlation with

  为了鉴定新的口服活性抑制剂，对1（ONO-6818）进行了进一步修饰。肽衍生物4b，4c和4n显示出比非肽衍生物3a-c更有效的抑制活性。结果，发现了一系列肽抑制剂4a-s和5a-v。在这些N-芳基衍生物中，5a-g，5i，5m和5o-v显示出口服活性。他们的口服活性与其代谢稳定性显示出良好的相关性。在仓鼠血浆中代谢极不稳定的化合物5h和5j-1没有口服活性。口服活性被认为是由至少两个因素共同决定的：口服吸收和代谢稳定性。
• METHOD FOR PRODUCING PYRAZOLE COMPOUND
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20170008853A1

  公开（公告）日：2017-01-12

  A method for producing a pyrazole compound represented by formula (1): (wherein R 1 represents an optionally substituted C 1-12 alkyl group, an optionally substituted C 3-12 cycloalkyl group, an optionally substituted C 6-16 aryl group, or an optionally substituted pyridyl group, R 2 and R 3 each independently represent a hydrogen atom, a halogen atom, a C 1-3 alkyl group, or a C 1-3 haloalkyl group), said method including a step in which a pyrazolidine compound represented by formula (2): (wherein R 1 , R 2 , and R 3 are as defined above) is reacted with a nitrite in the presence of an acid, allows a pyrazole compound to be produced industrially.

  一种生产由化学式（1）表示的吡唑化合物的方法：（其中R1代表可选取代的C1-12烷基基团，可选取代的C3-12环烷基基团，可选取代的C6-16芳基基团或可选取代的吡啶基团，R2和R3各自独立地代表氢原子，卤原子，C1-3烷基基团或C1-3卤代烷基基团），所述方法包括一步骤，在该步骤中，由化学式（2）表示的吡唑烷化合物：（其中R1，R2和R3如上定义）在酸的存在下与亚硝酸盐反应，从而可以工业化生产吡唑化合物。