(4-氯-1-苯基丁基)苯 | 3312-08-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (4-氯-1-苯基丁基)苯
• 英文名称: 4-chloro-1,1-diphenylbutane
• 英文别名: 1,1-diphenyl-4-chlorobutane；1,1'-(4-Chlorobutylidene)bisbenzene；(4-chloro-1-phenylbutyl)benzene
• CAS: 3312-08-1
• 化学式: C₁₆H₁₇Cl
• 分子量: 244.764
• InChiKey: JLNYNSOPLYOWFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2903999090

反应信息

• 作为反应物：
  描述：

  (4-氯-1-苯基丁基)苯 在 lithium aluminium tetrahydride 、 三氯化铝 、 sodium carbonate 、 sodium iodide 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 200.0 ℃ 、1.72 MPa 条件下， 反应 0.08h， 生成 N-[1-(4,4-Diphenyl-butyl)-4-phenyl-piperidin-4-ylmethyl]-formamide
  参考文献：
  名称：

  Synthesis and pharmacological characterization of novel inverse agonists acting on the viral-encoded chemokine receptor US28

  摘要：

  G-protein coupled receptors encoded by viruses represent an unexplored class of potential drug targets. In this study, we describe the synthesis and pharmacological characterization of the first class of inverse agonists acting on the HCMV-encoded receptor US28. It is shown that replacement of the 4-hydroxy group of lead compound I with a methylamine group results in a significant 6-fold increase in affinity. Interestingly, increasing the rigidity of the spacer by the introduction of a double bond also leads to a significant increase in binding affinity compared to 1. These novel inverse agonists serve as valuable tools to elucidate the role of constitutive signaling in the pathogenesis of viral infection and may have therapeutic potential as leads for new antiviral drugs. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.06.054
• 作为产物：
  描述：

  1,1'-(4-氯-1-丁烯亚基)二苯 在 钯 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 15.0h， 以to give the analytically pure 4-Chloro-1,1-diphenylbutane (201 mg, 99%) as a colorless oil的产率得到(4-氯-1-苯基丁基)苯
  参考文献：
  名称：

  Substituted heterocycle fused gamma-carbolines

  摘要：

  本发明涉及由结构式（I）表示的某些新化合物或其药学上可接受的盐形式，其中R1、R5、R6a、R6b、R7、R8、R9、X、b、k、m和n以及虚线在本文中描述。本发明还涉及包含这些新化合物作为活性成分的药物制剂以及利用这些新化合物及其制剂治疗某些疾病。本发明的化合物是5-羟色胺激动剂和拮抗剂，可用于控制或预防中枢神经系统疾病，包括肥胖症、焦虑症、抑郁症、精神病、精神分裂症、睡眠障碍、性功能障碍、偏头痛、头痛相关疾病、社交恐惧症以及胃肠道疾病，如胃肠道运动功能障碍。

  公开号：

  US06713471B1

文献信息

• Antihypertensive 1-[bis-(substituted
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US04590274A1

  公开（公告）日：1986-05-20

  Antihypertensive piperazineethylidenebenzocycloalkanes are provided. These compounds have the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are independently C.sub.1 -C.sub.6 alkyl, hydrogen, C.sub.1 -C.sub.6 alkoxy, hydroxy, or halo, or R.sub.1 and R.sub.2 or R.sub.2 and R.sub.3 together can form a methylenedioxy bridge; R.sub.4 is H or C.sub.1 -C.sub.6 alkyl; n is 0, 1 or 2; m is 0, 1, 2 or 3; and Ar.sub.1 and Ar.sub.2 are independently phenyl optionally substituted with one or two of halogen, hydroxy, or C.sub.1 -C.sub.6 alkoxy groups, or a pharmaceutically acceptable salt thereof.

  提供抗高血压哌嗪乙烯基苯环烷烃。这些化合物的化学式为：##STR1##其中R.sub.1、R.sub.2和R.sub.3独立地为C.sub.1 -C.sub.6烷基、氢、C.sub.1 -C.sub.6烷氧基、羟基或卤素，或者R.sub.1和R.sub.2或R.sub.2和R.sub.3可以共同形成一个亚甲二氧桥；R.sub.4为H或C.sub.1 -C.sub.6烷基；n为0、1或2；m为0、1、2或3；Ar.sub.1和Ar.sub.2独立地为苯基，可选择地取代一个或两个卤素、羟基或C.sub.1 -C.sub.6烷氧基，或其药用可接受盐。
• Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine]
  申请人：Hoechst-Roussel Pharmaceuticals Incorporated

  公开号：US04521537A1

  公开（公告）日：1985-06-04

  Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine] compounds of the formula ##STR1## where the substituents are as defined herein, are useful in the treatment of hypertension in mammals. Such compounds, their use as antihypertensive agents, pharmaceutical compositions containing the compounds, intermediates and processes for preparing the compounds are provided.

  Spiro[2H-1,4-苯并二氧杂环己啶-3(5H)4'-哌啶和-3'-吡咯烷]化合物的结构式如下：##STR1##其中取代基如本文所定义，适用于治疗哺乳动物的高血压。提供了这种化合物、其用作降压剂的用途、含有这些化合物的药物组合物、中间体以及制备这些化合物的方法。
• Synthesis of Diphenylmethyl Analogues and Their Affinity for the Melanocortin-4 Receptor and the Serotonin Transporter
  作者：Dai Nozawa、Taketoshi Okubo、Takaaki Ishii、Shigeyuki Chaki、Shigeru Okuyama、Atsuro Nakazato

  DOI：10.1248/cpb.55.1044

  日期：——

  had a relatively high affinity for the MC4 receptor. When diphenylmethyl analogues were further examined, compounds 12c and 18 were also found to exhibit a high affinity for the MC4 receptor (IC(50)=46.7 nM and 33.2 nM, respectively). Furthermore, compound 12c was also found to show a high affinity for the serotonin transporter (IC(50)=10.7 nM). Here, we describe the synthesis and biological evaluation

  在检查黑皮质素4受体（MC4受体）的拮抗剂时，我们发现含有二苯甲基部分的化合物12b对MC4受体具有相对较高的亲和力。当进一步检查二苯甲基类似物时，还发现化合物12c和18对MC4受体表现出高亲和力（分别为IC（50）= 46.7 nM和33.2 nM）。此外，还发现化合物12c对5-羟色胺转运蛋白显示出高亲和力（IC（50）= 10.7 nM）。在这里，我们描述了各种二苯基甲基类似物的合成和生物学评估，以及它们对MC4受体和血清素转运蛋白的作用。
• Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'pyrrolidine]
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US04405631A1

  公开（公告）日：1983-09-20

  Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3-pyrrolidine] compounds of the formula ##STR1## where the substituents are as defined herein, are useful in the treatment of hypertension in mammals. Such compounds, their use as antihypertensive agents, pharmaceutical compositions containing the compounds, intermediates and processes for preparing the compounds are provided.

  Spiro[2H-1,4-苯并二氧杂环戊三(5H)4'-哌啶和-3-吡咯烷]化合物的结构式如下：##STR1##其中取代基的定义如此，对于哺乳动物高血压的治疗具有用处。提供了这种化合物、它们作为降压剂的用途、含有这些化合物的药物组合物、中间体和制备这些化合物的方法。
• Antihypertensive spiro[benzofuran-azalkanes]
  申请人：Hoechst-Roussel Pharmaceuticals Incorporated

  公开号：US04452802A1

  公开（公告）日：1984-06-05

  There are described antihypertensive spiro[benzofuran-azalkanes] of the formula ##STR1## where X is hydrogen or halogen (F, Cl, Br, or I); m and n are each 0, 1 or 2 but m plus n is 1 or 2; and R is ##STR2## k being 2 or 3 and Y being hydrogen or halogen, which are useful as antihypertensive agents and methods for synthesizing the same.

  以下是翻译结果： 描述了一种抗高血压的螺[苯并呋喃-氮烷]类化合物，其化学式为##STR1##其中X为氢或卤素（F、Cl、Br或I）；m和n分别为0、1或2，但m加n等于1或2；R为##STR2##k为2或3，Y为氢或卤素。这些化合物可作为抗高血压药物，同时还提供了它们的合成方法。