(4-溴苯基)(2-氯苯基)甲酮 | 464190-33-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (4-溴苯基)(2-氯苯基)甲酮
• 英文名称: 2-chloro-4'-bromobenzophenone
• 英文别名: (4-bromophenyl)(2-chlorophenyl)methanone；4-Bromo-2'-chlorobenzophenone；(4-bromophenyl)-(2-chlorophenyl)methanone
• CAS: 464190-33-8
• 化学式: C₁₃H₈BrClO
• 分子量: 295.563
• InChiKey: YXCBKESUCSTXNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2914700090

反应信息

• 作为反应物：
  描述：

  3-氰基-5-甲氧基苯硼酸频那醇酯 、 (4-溴苯基)(2-氯苯基)甲酮 在 四(三苯基膦)钯 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 11.0h， 以83%的产率得到4'-(2-chlorobenzoyl)-5-methoxy-[1,1'-biphenyl]-3-carbonitrile
  参考文献：
  名称：

  Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance

  摘要：

  DOI：

  10.1016/j.ejmech.2021.113930
• 作为产物：
  描述：

  (4-bromophenyl)(2-chlorophenyl)methanol 在 chromium(VI) oxide 、 硫酸 作用下， 以 丙酮 为溶剂， 反应 0.17h， 生成 (4-溴苯基)(2-氯苯基)甲酮
  参考文献：
  名称：

  SAR of benzoylpyridines and benzophenones as p38α MAP kinase inhibitors with oral activity

  摘要：

  Benzoylpyridines and benzophenones were synthesized and evaluated in vitro as p38alpha inhibitors and in vivo in several models of rheumatoid arthritis. Oral activity was found to depend upon substitution: 1,1-dimethylpropynylamine substituted benzophenone 10b (IC50: 14 nM) and pyridinoyl substituted benzimidazole 17b (IC50: 21 nM) showed highest efficacy and selectivity with ED50S of 9.5 and 8.6 mg/kg po in CIA. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.03.111

文献信息

• Insertion of arynes into carbon–halogen σ-bonds: regioselective acylation of aromatic rings
  作者：Hiroto Yoshida、Yasuhiro Mimura、Joji Ohshita、Atsutaka Kunai

  DOI：10.1039/b701581j

  日期：——

  Arynes were found to insert into carbon–halogen σ-bonds of various acid halides, enabling acyl and halogen moieties to be introduced simultaneously into adjacent positions of aromatic rings.

  氮烯能够插入各种酰卤中的碳-卤素σ键，从而使得酰基和卤素基团同时引入到芳香环的相邻位置。
• Hallogenated aminobenzophenones and aminobenzoylpyridines as inhibitors of il-1and tnf
  申请人：——

  公开号：US20040097731A1

  公开（公告）日：2004-05-20

  Compounds of formula I and pharmaceutically-acceptable and -cleavable esters thereof and acid addition salts thereof wherein the symbols are as defined are MAP kinase inhibitors, useful pharmaceutically for treating TNF&agr; and IL-1 mediated diseases such as rheumatoid arthritis and diseases of bone metabolism, e.g. osteoporosis.

  化合物I的公式及其药用可接受和可水解酯以及其酸加成盐，其中符号如定义的那样，是MAP激酶抑制剂，可用于药物治疗TNFα和IL-1介导的疾病，如类风湿性关节炎和骨代谢疾病，例如骨质疏松症。
• Hallogenated aminobenzophenones and aminobenzoylpyridines as inhibitors of IL-1 and TNF
  申请人：Révész Lászlo

  公开号：US06919336B2

  公开（公告）日：2005-07-19

  Compounds of formula I and pharmaceutically-acceptable and -cleavable esters thereof and acid addition salts thereof wherein the symbols are as defined are MAP kinase inhibitors, useful pharmaceutically for treating TNFα and IL-1 mediated diseases such as rheumatoid arthritis and diseases of bone metabolism, e.g. osteoporosis.

  式I化合物及其药学上可接受和可水解酯及其酸加成盐是MAP激酶抑制剂，可用于药学上治疗TNFα和IL-1介导的疾病，例如类风湿性关节炎和骨代谢疾病，如骨质疏松症。
• Poly(arylene thioether) copolymers and process for production thereof
  申请人：Tosoh Corporation

  公开号：EP0351136A2

  公开（公告）日：1990-01-17

  A novel class of poly(arylene) thioether) copolymers which are not only thermoplastic but thermosetting in nature. The copolymer may be prepared by copolymerizing a combination of dihalogenobenzonitrile, dihalogenobenzophenone and thioetherifying agent in an organic solvent. The copolymers are highly resistant to heat and solvents and exhibit excellent mechanical properties at raised temperatures.

  一种新型聚（芳烯烃）硫醚共聚物，不仅具有热塑性，还具有热固性。这种共聚物可通过在有机溶剂中共聚二卤代苯腈、二卤代二苯甲酮和硫醚化剂的组合来制备。 这种共聚物具有很强的耐热性和耐溶剂性，在高温下具有优异的机械性能。
• Catalytic Friedel–Crafts acylation: magnetic nanopowder CuFe2O4 as an efficient and magnetically separable catalyst
  作者：Ramarao Parella、Naveen、Amit Kumar、Srinivasarao Arulananda Babu

  DOI：10.1016/j.tetlet.2013.01.081

  日期：2013.3

  Catalytic regioselective Friedel-Crafts acylation of an array of anisoles/arenes with various acid chlorides using 5-20 mol % of magnetic nanopowder CuFe2O4 is reported. Unlike the conventional Friedel-Crafts reactions, which are catalyzed by moisture sensitive homogeneous catalysts/promoters, the nanopowder CuFe2O4 catalyst is moisture insensitive and the product/ketone-catalyst isolation is easily achieved using the magnetic properties of CuFe2O4. (C) 2013 Elsevier Ltd. All rights reserved.