(4-硝基苯基)-磷酸 | 2175-86-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (4-硝基苯基)-磷酸
• 英文名称: 4-nitropheylphosphonic acid
• 英文别名: 4-nitrobenzenephosphonic acid；p-nitrophenyl phosphonic acid；4-nitrophenylphosphonic acid；p-nitrophenylphosphonic acid；para-nitrophenylphosphate；pNPP；(p-Nitrophenyl)phosphonic acid；(4-nitrophenyl)phosphonic acid
• CAS: 2175-86-2
• 化学式: C₆H₆NO₅P
• 分子量: 203.091
• InChiKey: CBWCNKVANCTCAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  (4-硝基苯基)-磷酸 在 氯化亚砜 作用下， 反应 5.0h， 生成 4-(Nitrophenyl)phosphonsaeure-dichlorid
  参考文献：
  名称：

  Harger, Martin J. P.; Smith, Adrian, Journal of the Chemical Society. Perkin transactions I, 1985, p. 1787 - 1792

  摘要：

  DOI：
• 作为产物：
  描述：

  4-nitrobenzenediazonium tetrafluoroborate 生成 (4-硝基苯基)-磷酸
  参考文献：
  名称：

  Williams,A. et al., Journal of the Chemical Society. Perkin transactions II, 1973, p. 25 - 33

  摘要：

  DOI：

文献信息

• [EN] METAL-FREE DIRECT ARYLATION OF DIALKYL PHOSPHONATES FOR THE SYNTHESIS OF MIXED ALKYL ARYL PHOSPHONATES<br/>[FR] ARYLATION DIRECTE SANS MÉTAL DE PHOSPHONATES DE DIALKYLE POUR LA SYNTHÈSE DE PHOSPHONATES D'ARYLE ALKYLE MIXTES
  申请人：THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIV OF NEVADA LAS VE

  公开号：WO2019028391A1

  公开（公告）日：2019-02-07

  Provided herein are phosphates, thiophosphates, phosphonates, and phosphinates, methods of making same, and methods of using these compounds and methods for the generation of pharmaceutically relevant phosphate, phosphonate, and phosphinate analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本文提供了磷酸盐、硫代磷酸盐、膦酸盐和膦酸盐，以及制备这些化合物的方法，以及使用这些化合物和用于生成与药用相关的磷酸盐、膦酸盐和膦酸盐类似物的方法。此摘要旨在作为搜索特定领域的扫描工具，并不限制本发明。
• Etude d'un schema de synthese peptidique intramoleculaire a l'aide de derives du phosphore tetraedrique
  作者：M. Mulliez

  DOI：10.1016/s0040-4020(01)97957-8

  日期：——

  A new scheme of repetitive and controlled peptide synthesis offers two advantages compared to the usual methods of synthesis : two steps only are used for the prolongation of a peptide chain with an aminoacid residue and the risk of racemisation is minimized. The two postulated steps are verified particularly by the rearrangement, in an alkaline alcoholic medium, of phosphordiamides 1 incorporating

  与常规的合成方法相比，重复和受控的肽合成的新方案具有两个优点：仅两个步骤用于延长带有氨基酸残基的肽链，并且将外消旋化的风险降至最低。特别地，通过在碱性醇介质中重新排列掺入一个氨基酸残基的磷二酰胺1，导致形成肽衍生物6和8，证实了这两个假定的步骤。讨论了此方法的严重局限性。
• Interactions of guanidinium with benzene-sulphonic, -phosphonic and -arsonic acids and several of their nitro-derivatives
  作者：Kay Latham、James E. Downs、Colin J. Rix、Jonathan M. White

  DOI：10.1016/j.molstruc.2010.11.062

  日期：2011.2

  Abstract The supramolecular interactions of the planar guanidinium cation ( C ( NH 2 ) 3 + ) with benzenesulphonate (1), -phosphonate (2) and -arsonate (3) anions, and several of their 3- and 4-nitro-substituted derivatives is reported. In all cases well-defined crystalline materials, containing hydrogen-bonded networks with quasi-hexagonal sheet lattices were formed. However, the unsubstituted sulphonate

  摘要 平面胍阳离子 ( C ( NH 2 ) 3 + ) 与苯磺酸根 (1)、-膦酸根 (2) 和-砷酸根 (3) 阴离子及其几种 3- 和 4-硝基取代衍生物的超分子相互作用被报道。在所有情况下，都形成了明确定义的晶体材料，包含具有准六方片晶格的氢键网络。然而，未取代的磺酸盐 (1) 形成了 1:1 胍:磺酸盐双层结构，而未取代的膦酸盐 (2) 和砷酸盐 (3) 形成了 2:1 胍:膦酸盐/砷酸盐单层结构，水被包裹在晶体中空隙。与（1）中的对称六方形式相比，额外的氢键相互作用导致（2）/（3）中的晶体空隙变形。对于硝基取代的磺酸盐衍生物，1：3-硝基苯磺酸盐 (4) 保留了母体 (1) 的 1 双层结构，但 4-硝基苯磺酸盐 (6) 转化为 1:1 单层系统。对于硝化膦酸，观察到相反的情况，其中（5）中的 4-硝基苯膦酸阴离子对（2）中看到的 2:1 单层结构和准六边形片几乎没有破坏，但
• Generation of Polyclonal Catalytic Antibodies Against Cocaine Using Transition State Analogs of Cocaine Conjugated to Diphtheria Toxoid.
  作者：Garo P. BASMADJIAN、Satendra SINGH、Budiono SASTRODJOJO、Blaine T. SMITH、Kwasi AVOR、Fengchun CHANG、Stanley L. MILLS、Thomas W. SEALE

  DOI：10.1248/cpb.43.1902

  日期：——

  Six novel transition state analogs (TSAs) of cocaine (10-14 and 17) and one non-cocaine, p-aminophenyl-phosphonyl ester of cyclohexanol (19), were synthesized and characterized by 1H- and 13C-NMR and FAB-MS.(1R)-ecgonine methyl ester or cyclohexanol were subjected to phenylphosphonylation in the presence of dicyclohexyl carbodiimde (DCC) and 4-N, N-dimethyl aminopyridine (4-DMAP). TSA-IV (10), however, was synthesized from norcocaine which was protected with dibromoethane to yield 4 before acid hydrolysis, esterification and phenyl-phosphonylation were carried out. TSA-III (11) TSA-I (12) and (19), using various length spacer arms, were coupled with the immunogenic protein, diphtheria toxoid (DT). The TSAs coupled with DT were used to immunize mice and after appropriate boosts their sera were tested for the presence and titer of anti-TSA polyclonal antibodies using ELISA. Preliminary results show that the mice immunized with these TSAs produced high titers of polyclonal catalytic antibodies, except for (19), with the ability to hydrolyze the substrate 125I-4'-iodococaine in an in vitro assay, even in the presence of noncatalytic anti-TSA antibodies.

  合成了六种新型可卡因过渡态类似物 (TSA) (10-14 和 17) 和一种非可卡因环己醇对氨基苯基膦酰酯 (19)，并通过 1H 和 13C-NMR 和 FAB-MS 进行表征(1R)-芽子碱甲酯或环己醇在二环己基碳二亚胺(DCC)和4-N，N-二甲基氨基吡啶(4-DMAP)存在下进行苯基膦酰化。然而，TSA-IV (10) 是由去甲可卡因合成的，在进行酸水解、酯化和苯基膦酰化之前，将去甲可卡因用二溴乙烷保护以产生4。 TSA-III (11) TSA-I (12) 和 (19) 使用不同长度的间隔臂与免疫原性蛋白白喉类毒素 (DT) 偶联。 TSA 与 DT 结合用于免疫小鼠，并在适当加强后，使用 ELISA 测试其血清中抗 TSA 多克隆抗体的存在和滴度。初步结果表明，用这些 TSA 免疫的小鼠产生了高滴度的多克隆催化抗体（（19）除外），在体外测定中具有水解底物 125I-4'-碘可卡因的能力，即使在存在非催化抗体的情况下也是如此。 -TSA 抗体。
• Process for Producing Polyester, Polyester Produced Using Said Process, and Polyester Molded Product
  申请人：Kageyama Katsuhiko

  公开号：US20080249280A1

  公开（公告）日：2008-10-09

  This invention provides a polyester and a polyester molded product, which, while maintaining color tone, transparency, and thermal stability, can realize a high polycondensation rate, are less likely to cause the production of polycondensation catalyst-derived undesired materials, and can simultaneously meet both quality and cost effectiveness requirements, which can exhibit the characteristic features, for example, in the fields of ultrafine fibers, high transparent films for optical use, or ultrahigh transparent molded products. These advantages can be realized by using, in the production of a polyester in the presence of an aluminum compound-containing polyester polycondensation catalyst, an aluminum compound having an absorbance of not more than 0.0132 as measured in the form of an aqueous aluminum compound solution, prepared by dissolving the aluminum compound in pure water to give a concentration of 2.7 g/liter in terms of the amount of aluminum element, under conditions of cell length 1 cm and wavelength 680 nm.

  本发明提供了一种聚酯和聚酯成型产品，可以在保持色调、透明度和热稳定性的同时，实现高聚酯化速率，不太可能引起聚酯化催化剂来源的不良材料的生产，并且可以同时满足质量和成本效益的要求，这些优点可以在超细纤维、用于光学的高透明薄膜或超高透明成型产品等领域展现出特征性能。通过在含有铝化合物聚酯聚合催化剂的聚酯生产中使用具有吸光度不超过0.0132的铝化合物，可以实现这些优点。该吸光度是在细胞长度为1厘米，波长为680纳米的条件下，将铝化合物溶解在纯水中以给定铝元素量浓度为2.7克/升形成的水溶性铝化合物溶液中测量得出的。