(5-氨基-2-氯苯基)苯基甲酮 | 46495-60-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (5-氨基-2-氯苯基)苯基甲酮
• 英文名称: 5-amino-2-chlorobenzophenone
• 英文别名: 3-Amino-6-chlorophenyl phenyl ketone；5-Amino-2-chlor-benzophenon；(5-Amino-2-chlorophenyl)(phenyl)methanone；(5-amino-2-chlorophenyl)-phenylmethanone
• CAS: 46495-60-7
• 化学式: C₁₃H₁₀ClNO
• 分子量: 231.681
• InChiKey: KZJVQORHPPEMBG-UHFFFAOYSA-N

物化性质

• 沸点：
  416.1±30.0 °C(Predicted)
• 密度：
  1.274±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (5-氨基-2-氯苯基)苯基甲酮 在 三乙胺 、 三氯氧磷 作用下， 以 水 为溶剂， 反应 0.05h， 生成 2-chloro-5-aminothiobenzophenone
  参考文献：
  名称：

  在无溶剂条件下使用PSCl 3 / H 2 O / Et 3 N系统进行微波辅助的硫磺化反应

  摘要：

  一种新的硫化协议羰基化合物，与系统PSCl 3 / H 2 O /的Et 3 N有被发现。通过这种简单方便的方法，在无溶剂条件下用微波辐照，可以实现各种硫代羰基化合物（如硫代酰胺，硫代内酰胺，硫代酮，噻吨酮和硫代rid啶酮）的清洁，快速，高效合成。

  DOI：

  10.1021/jo7022069
• 作为产物：
  描述：

  2-氯-5-硝基苯甲酰氯 在 三氯化铝 、 铁粉 、 溶剂黄146 作用下， 生成 (5-氨基-2-氯苯基)苯基甲酮
  参考文献：
  名称：

  Utility of Complementary Molecular Reactivity and Molecular Recognition (CMR/R) Technology and Polymer-Supported Reagents in the Solution-Phase Synthesis of Heterocyclic Carboxamides

  摘要：

  The use of our recently reported chemical library purification strategy in the development of a herbicidal lead, N-(3-benzoylphenyl)-3-(1,1-dimethylethyl)-1-methyl-1H-pyrazole-5-carboxamide (3), is described. The approach applying fundamental properties of complementary molecular reactivity and molecular recognition (CMR/R) as the basis for a general purification strategy was utilized. Polymeric reagents were used in the synthesis to generate reactive species involved in product formation, and complementary molecular reactivity/molecular recognition polymer 8 (CMR/R polymer 8) was used in the solution-phase syntheses of building blocks, primary libraries, and lead refinement libraries. An extension of the CMR/R methodology was applied, utilizing a sequestration enabling reagent (SER), transforming a reactant into an electrophilic species sequestrable by CMR/R polymer 8. This library purification strategy enabled rapid lead generation and lead refinement to afford herbicide 27o. The CMR/R solid-phase purification technique enabled a simple, general, and powerful protocol, eliminating the usual tedious and time-consuming methods required for solution-phase product purification. The result was the synthesis of hundreds of compounds, prepared in a relatively short time, leading to a compound with a 4-fold improvement in herbicidal activity over the initial lead.

  DOI：

  10.1021/jo970571i

文献信息

• Sulphonamides derived from diarylmethanes, the processes for preparing
  申请人：SANOFI

  公开号：US04980349A1

  公开（公告）日：1990-12-25

  The invention relates to new compounds corresponding to formula I: ##STR1## in which: W represents C=O, CH.sub.2 or CHOH, Z represents ##STR2## R.sub.1 and R.sub.2 represent especially Cl or F, R, R' and R" represent especially H, X represents especially CH.sub.2, Y represents especially COOH, u and v are two integers ranging from 0 to 10, p and q take the value 0 or 1, n and m are two integers ranging 0 to 10 and t is 0 or 1 the total number of carbon atoms in the chain ##STR3## ranging from 2 to 20, and to their physiologically acceptable salts obtained with organic or inorganic acids. These compounds are useful for preparing medicinal products which have, especially, anti-inflammatory properties.

  该发明涉及与以下式I相对应的新化合物：##STR1## 其中：W代表C=O、CH.sub.2或CHOH，Z代表##STR2## R.sub.1和R.sub.2特别代表Cl或F，R、R'和R"特别代表H，X特别代表CH.sub.2，Y特别代表COOH，u和v是从0到10的两个整数，p和q取值为0或1，n和m是从0到10的两个整数，t为0或1链中的碳原子总数##STR3##范围从2到20，并且它们与有机或无机酸获得的生理上可接受的盐。这些化合物可用于制备具有特别抗炎性能的药物制剂。
• Trisubstituted carbocyclic cyclophilin binding compounds and their use
  申请人：——

  公开号：US20020165275A1

  公开（公告）日：2002-11-07

  The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invention further relates to the uses of these compounds and compositions for binding CyP-type proteins, inhibiting their peptidyl-prolyl isomerase activity, and for research, development, and therapeutic applications in a variety of medical disorders.

  本发明涉及一种新型的非肽类小有机化合物，其具有与环肽亚精蛋白（CyP）型免疫蛋白亲和力，并且涉及包含所述化合物中的一个或多个的药物组合物。该发明还涉及这些化合物和组合物用于结合CyP型蛋白，抑制其肽基脯氨酸异构酶活性，并在各种医学疾病的研究、开发和治疗应用中的用途。
• Potentiators of glutamate receptors
  申请人：——

  公开号：US20040006114A1

  公开（公告）日：2004-01-08

  The present invention relates to potentiators of metabotropic glutamate receptor function and specifically provides compounds of formula I, compositions thereof and methods of using the same. 1

  本发明涉及代谢型谷氨酸受体功能的增强剂，具体提供了化合物I的公式、其组合物以及使用方法。
• Exploring the influence of designer surfactant hydrophobicity in key C C/C N bond forming reactions
  作者：Singarajanahalli Mundarinti Krishna Reddy、Jagatheeswaran Kothandapani、Megarajan Sengan、Anbazhagan Veerappan、Subramaniapillai Selva Ganesan

  DOI：10.1016/j.mcat.2019.01.006

  日期：2019.3

  aqueous medium via 5-exo-trig cyclization reaction. The scope of the reaction was extended to intermolecular Csp2-Csp2 and Csp2-N bond forming reactions in water. Systematic investigations revealed that altering hydrophobicity of surfactant influences the yield of both CC and CN bond forming reactions in water.

  探索了设计胶束介质，以通过5-exo-trig环化反应在水性介质中将各种苯胺转化为相应的密集取代的生物学相关的粪臭素衍生物。反应的范围扩展到在水中的分子间Csp 2 -Csp 2和Csp 2 -N键形成反应。系统研究表明，改变表面活性剂的疏水性会影响水中C C和C N键形成反应的产率。
• CARROLL, R. D.;MILLER, M. W.;MYLARI, B. L.;CHAPPEL, L. R.;HOWES, H. L. ,,+, J. MED. CHEM., 1983, 26, N 1, 96-100
  作者：CARROLL, R. D.、MILLER, M. W.、MYLARI, B. L.、CHAPPEL, L. R.、HOWES, H. L. ,,+

  DOI：——

  日期：——