(5S,6Z,8E,10E,14Z)-5-羟基-12-氧代二十-6,8,10,14-四烯酸 | 136696-10-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: (5S,6Z,8E,10E,14Z)-5-羟基-12-氧代二十-6,8,10,14-四烯酸
• 中文别名: 2-硝基-1-(2-苯氧基乙基)-1H-咪唑
• 英文名称: 12-keto-leukotriene b4
• 英文别名: 12-Oxo-ltb4；(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid
• CAS: 136696-10-1
• 化学式: C₂₀H₃₀O₄
• 分子量: 334.456
• InChiKey: SJVWVCVZWMJXOK-NOJHDUNKSA-N

物化性质

• 沸点：
  524.2±50.0 °C(Predicted)
• 密度：
  1.036±0.06 g/cm3(Predicted)
• 溶解度：
  DMF：可混溶； DMSO：可混溶；乙醇：可混溶； PBS (pH 7.2)：> 1 mg/mL
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  白三烯B4 在 potassium chloride 、 human microsomal dehydrogenase reductase 9 作用下， 以 aq. phosphate buffer 为溶剂， 生成 (5S,6Z,8E,10E,14Z)-5-羟基-12-氧代二十-6,8,10,14-四烯酸
  参考文献：
  名称：

  Dehydrogenase reductase 9 (SDR9C4) and related homologs recognize a broad spectrum of lipid mediator oxylipins as substrates

  摘要：

  DOI：

  10.1016/j.jbc.2021.101527

文献信息

• GENE INVOLVED IN IMMORTALIZATION OF HUMAN CANCER CELL AND USE THEREOF
  申请人：Kabushiki Kaisha Yakult Honsha

  公开号：EP2034017A1

  公开（公告）日：2009-03-11

  The present invention provides a gene related to cancer cell immortalization (an immortalization determining gene) and a process that is useful for selective cancer treatment targeting a cancer cell having the gene. The present invention determines an immortalized cancer cell using a polynucleotide having a base sequence of at least 15 bases that specifically hybridizes with a continuous base sequence of at least 15 bases within any one of abase sequences represented by SEQ ID Nos. 1 to 13. In the foregoing process, the polynucleotide is used as a primer or probe for detecting an immortalization determining gene that exhibits high expression specifically in an immortalized cancer cell.

  本发明提供了一种与癌细胞永生化有关的基因（永生化决定基因）和一种可用于针对具有该基因的癌细胞进行选择性癌症治疗的方法。本发明使用一种多核苷酸来确定永生化癌细胞，该多核苷酸具有至少 15 个碱基的碱基序列，该碱基序列与 SEQ ID 号 1 至 13 所代表的任何一个碱基序列中至少 15 个碱基的连续碱基序列特异性杂交。在上述过程中，多核苷酸被用作引物或探针，用于检测在永生化癌细胞中特异性高表达的永生化决定基因。
• Gene involved in immortalization of human cancer cell and use thereof
  申请人：Kabushiki Kaisha Yakult Honsha

  公开号：EP2412805A1

  公开（公告）日：2012-02-01

  The present invention provides a gene related to cancer cell immortalization (an immortalization determining gene) and a process that is useful for selective cancer treatment targeting a cancer cell having the gene. The present invention determines an immortalized cancer cell using a polynucleotide having a base sequence of at least 15 bases that specifically hybridizes with the base sequence represented by SEQ ID No. 13. In the foregoing process, the polynucleotide is used as a primer or probe for detecting an immortalization determining gene that exhibits high expression specifically in an immortalized cancer cell.

  本发明提供了一种与癌细胞永生化有关的基因（永生化决定基因）和一种可用于针对具有该基因的癌细胞进行选择性癌症治疗的方法。本发明使用一种多核苷酸来确定永生化癌细胞，该多核苷酸具有至少 15 个碱基序列，能与 SEQ ID 编号 13 所代表的碱基序列特异性杂交。在上述过程中，多核苷酸被用作引物或探针，用于检测在永生化癌细胞中特异性高表达的永生化决定基因。
• 12-Oxo-LTB4, a Key Pivotal Intermediate in LTB4 Metabolism
  作者：Subhash P. Khanapure、Sukumar Manna、Joshua Rokach、Robert C. Murphy、Pat Wheelan、William S. Powell

  DOI：10.1021/jo00111a044

  日期：1995.3

  The first total synthesis of the very unstable and elusive biochemical intermediate 5(S)-hydroxy-12-oxo-6(Z),8(E),10(E),14(Z)-eicosatetraenoic acid (12-oxo-LTB(4)) (2) has been accomplished. Incubation of the synthetic 12-oxo-LTB(4) (2) with human keratinocytes produced 5(S),12-dihydroxy-6-glutathionyl-7(E),9(E),14(Z)-eicosatrienoic acid (c-LTB(3)) and 5(S),12-dihydroxy-6-cysteinylglycyl-7(E),9(E),14(Z)-eicosatrienoic acid (d-LTB(3)), two new intriguing mediators which have been identified recently during the incubations of LTB(4) with keratinocytes. We have also confirmed the identity of 12-oxo-LTB(4) prepared from porcine leukocytes by comparison with the synthetic material and identified the formation in these incubates of the 6-trans-isomer of 12-oxo-LTB(4).
• PREVENTION OF SALMONELLA RECRUDESCENSE
  申请人：Universiteit Gent

  公开号：EP2736922B1

  公开（公告）日：2017-11-01
• US9125855B2
  申请人：——

  公开号：US9125855B2

  公开（公告）日：2015-09-08