(5Z,8Z,10E,12S,14Z,17Z)-12-羟基-5,8,10,14,17-二十碳五烯酸 | 81187-21-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: (5Z,8Z,10E,12S,14Z,17Z)-12-羟基-5,8,10,14,17-二十碳五烯酸
• 英文名称: 12-Hydroxyeicosapentaenoic acid
• 英文别名: (5Z,8Z,10E,14Z,17Z)-12-hydroxyicosa-5,8,10,14,17-pentaenoic acid
• CAS: 81187-21-5
• 化学式: C₂₀H₃₀O₃
• 分子量: 318.4
• InChiKey: MCRJLMXYVFDXLS-QGQBRVLBSA-N

物化性质

• 溶解度：
  0.1 M Na2CO3：2 mg/mL； DMF：可混溶； DMSO：可混溶；乙醇：可混溶； PBS pH 7.2：0.8 mg/mL
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Biomarkers for sensitive detection of statin-induced muscle toxicity
  申请人：Zora Biosciences OY

  公开号：EP2508895A1

  公开（公告）日：2012-10-10

  The present invention inter alia provides a method, and uses thereof, of predicting statin-induced muscle toxicity or its complications, such as myalgia, myopathy and rhabdomyolysis, by detecting the lipid concentrations or lipid-lipid concentration ratios of a biological sample and comparing them to a control. This method has identified lipid markers that are more specific and sensitive in detecting these statin-induced muscle toxicity than the currently utilized clinical markers. Also provided is an antibody towards said lipids, and the use thereof for predicting, diagnosing, statin-induced muscle toxicity. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of statin-induced muscle toxicity.

  本发明特别提供了一种方法及其用途，通过检测生物样本的脂质浓度或脂质-脂质浓度比，并将其与对照组进行比较，预测他汀类药物诱发的肌肉毒性或其并发症，如肌痛、肌病和横纹肌溶解症。与目前使用的临床标记物相比，该方法发现的脂质标记物在检测他汀类药物引起的肌肉毒性方面更具特异性和敏感性。本发明还提供了一种针对上述脂质的抗体，及其用于预测、诊断他汀类药物诱发的肌肉毒性。本发明还涉及包含脂质和/或其抗体的试剂盒，用于预测和/或诊断他汀类药物诱发的肌肉毒性。
• BIOMARKERS FOR SENSITIVE DETECTION OF STATIN-INDUCED MUSCLE TOXICITY
  申请人：Zora Biosciences OY

  公开号：EP2977764A1

  公开（公告）日：2016-01-27

  The present invention inter alia provides a method, and uses thereof, of predicting statin-induced muscle toxicity or its complications, such as myalgia, myopathy and rhabdomyolysis, by detecting the lipid concentrations or lipid-lipid concentration ratios of a biological sample and comparing them to a control. This method has identified lipid markers that are more specific and sensitive in detecting these statin-induced muscle toxicity than the currently utilized clinical markers. Also provided is an antibody towards said lipids, and the use thereof for predicting, diagnosing, statin-induced muscle toxicity. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of statin-induced muscle toxicity.

  本发明特别提供了一种方法及其用途，通过检测生物样本的脂质浓度或脂质-脂质浓度比，并将其与对照组进行比较，预测他汀类药物诱发的肌肉毒性或其并发症，如肌痛、肌病和横纹肌溶解症。与目前使用的临床标记物相比，该方法发现的脂质标记物在检测他汀类药物引起的肌肉毒性方面更具特异性和敏感性。本发明还提供了一种针对上述脂质的抗体，及其用于预测、诊断他汀类药物诱发的肌肉毒性。本发明还涉及包含脂质和/或其抗体的试剂盒，用于预测和/或诊断他汀类药物诱发的肌肉毒性。
• Oils with anti-inflammatory activity containing natural specialized proresolving mediators and their precursors
  申请人：SOLUTEX NA LLC

  公开号：US10568858B2

  公开（公告）日：2020-02-25

  The present invention encompasses oils that have anti-inflammatory or resolution-stimulating activity that contain or are enriched with Specialized Proresolving Mediators (SPM) or SPM precursors, which originate from an oil obtained from organisms containing long chain omega-3 polyunsaturated fatty acids, such as fish, crustaceae, algae, and mollusks. The invention also encompasses a method for the production of these oils, and the utilization of the oils for nutritional supplements, pharmaceutical formulations, and cosmetic formulations, which can be employed for treating an inflammatory condition.

  本发明包括具有抗炎或刺激溶解活性的油类，这些油类含有或富含特化促溶解介质（SPM）或 SPM 前体，这些特化促溶解介质或 SPM 前体来源于从含有长链欧米加-3 多不饱和脂肪酸的生物（如鱼类、甲壳类、藻类和软体动物）中获得的油类。本发明还包括生产这些油的方法，以及将这些油用于营养补充剂、药物制剂和化妆品制剂的方法，这些制剂可用于治疗炎症。
• Oils with anti-inflammatory activity containing natural Specialized Proresolving Mediators and their precursors
  申请人：Solutex NA LLC

  公开号：US11077083B2

  公开（公告）日：2021-08-03

  The present invention encompasses oils that have anti-inflammatory or resolution-stimulating activity that contain or are enriched with Specialized Proresolving Mediators (SPM) or SPM precursors, which originate from an oil obtained from organisms containing long chain omega-3 polyunsaturated fatty acids, such as fish, crustaceae, algae, and mollusks. The invention also encompasses a method for the production of these oils, and the utilization of the oils for nutritional supplements, pharmaceutical formulations, and cosmetic formulations, which can be employed for treating an inflammatory condition.

  本发明包括具有抗炎或刺激溶解活性的油类，这些油类含有或富含特化促溶解介质（SPM）或 SPM 前体，这些特化促溶解介质或 SPM 前体来源于从含有长链欧米加-3 多不饱和脂肪酸的生物（如鱼类、甲壳类、藻类和软体动物）中获得的油类。本发明还包括生产这些油的方法，以及将这些油用于营养补充剂、药物制剂和化妆品制剂的方法，这些制剂可用于治疗炎症。
• OILS WITH ANTI-INFLAMMATORY ACTIVITY CONTAINING NATURAL SPECIALIZED PRORESOLVING MEDIATORS AND THEIR PRECURSORS
  申请人：Solutex NA LLC

  公开号：EP2858496A2

  公开（公告）日：2015-04-15