(6CI)-嘧啶并[4,5-d]嘧啶-2(1H)-酮 | 120614-17-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: (6CI)-嘧啶并[4,5-d]嘧啶-2(1H)-酮
• 英文名称: Pyrimido[4,5-d]pyrimidin-2(1H)-one
• 英文别名: 1H-pyrimido[4,5-d]pyrimidin-2-one
• CAS: 120614-17-7
• 化学式: C₆H₄N₄O
• 分子量: 148.12
• InChiKey: JPOJBQLUJAIHHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-[3-(tert-butyldiphenylsilyloxyethyl)phenyl]-3-(2,4-dichlorophenyl)-7-[4-[2-(diethylamino)ethoxy]anilino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one 、 、 四丁基氟化铵 在 silica gel 、 正己烷 、 3-(2,4-dichlorophenyl)-7-[4-[2-(diethylamino)ethoxy]anilino]-3,4-dihydro-1-[3-(2-hydroxyethyl))phenyl 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以gave 60 mg (42%) 3-(2,4-dichlorophenyl)-7-[4-[2-(diethylamino)ethoxy]anilino]-3,4-dihydro-1-[3-(2-hydroxyethyl))phenyl]pyrimido[4,5-d]pyrimidin-2(1H)-one as a white solid of melting point 110° C.的产率得到(6CI)-嘧啶并[4,5-d]嘧啶-2(1H)-酮
  参考文献：
  名称：

  Bicyclic nitrogen heterocycles

  摘要：

  式中R.sup.1代表氢、低碳基、芳基、芳基-低碳基、杂环芳基、杂环芳基-低碳基、低环烷基或低环烷基-低碳基，R.sup.2代表低碳基、芳基、芳基-低碳基、杂环芳基、杂环芳基-低碳基、低环烷基或低环烷基-低碳基，R.sup.3代表氢、低碳基、芳基、芳基-低碳基、杂环芳基、杂环芳基-低碳基、低环烷基、低环烯基或低环烷基-低碳基，以及其药学上可接受的盐是蛋白激酶抑制剂。它们可用于治疗或预防炎症、免疫、肿瘤、支气管肺部、皮肤和心血管疾病，在哮喘、中枢神经系统疾病或糖尿病并发症的治疗中，或用于移植手术后预防移植排斥。

  公开号：

  US06150373A1

文献信息

• [EN] AMIDE DERIVATIVES OF 7-AMINO-3-PHENYL-DIHYDROPYRIMIDO [4,5-d]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS<br/>[FR] DERIVES AMIDE DE 7-AMINO-3-PHENYL-DIHYDROPYRIMIDO [4,5-D]PYRIMIDINONES, AINSI QUE LEUR PREPARATION ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE LA PROTEINE KINASE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2006024487A1

  公开（公告）日：2006-03-09

  The present invention relates to novel amide derivatives of 7-amino-3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).

  本发明涉及7-氨基-3-苯基二氢嘧啶[4,5-d]嘧啶酮的新型酰胺衍生物，其制造工艺，含有它们的药物及其制造，以及这些化合物作为药物活性剂的使用。本发明的衍生物是通用公式（I）的新化合物。
• Amide Derivatives of 3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents
  申请人：Engh Richard

  公开号：US20070232611A1

  公开（公告）日：2007-10-04

  The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).

  本发明涉及3-苯基二氢嘧啶并[4,5-d]嘧啶酮的新酰胺衍生物，以及其制备方法、含有它们的药物、以及这些化合物作为药用活性剂的用途。本发明的衍生物是一般式(I)的新化合物。
• [EN] USE OF KINASE INHIBITORS TO PROMOTE NEOCHONDROGENESIS<br/>[FR] UTILISATION D'INHIBITEURS DE KINASES POUR FAVORISER LA NEOCHONDROGENESE
  申请人：WARNER LAMBERT CO

  公开号：WO2006038112A1

  公开（公告）日：2006-04-13

  This invention provides methods for utilizing compounds that inhibit cyclin­dependent kinase and tyrosine kinase enzymes in the promotion of neochondrogenesis and the enhancement, protection and repair of cartilage. In certain embodiments the invention relates to methods of using compounds of formula (I): and pharmaceutically acceptable salts thereof, to promote neochondrogenesis, wherein, R1,R2, R3, R4, R5, R6, A, B, D, and E have any of the values defined therefor in the specification.

  本发明提供了一种利用抑制周期素依赖性激酶和酪氨酸激酶的化合物来促进新软骨生成以及增强、保护和修复软骨的方法。在某些实施方式中，本发明涉及使用公式(I)的化合物以及药用可接受的盐来促进新软骨生成，其中R1、R2、R3、R4、R5、R6、A、B、D和E具有说明书中为其定义的任何值。
• Kinase inhibitors
  申请人：——

  公开号：US20040019210A1

  公开（公告）日：2004-01-29

  This invention provides phenyl-substituted pyrimidopyrimidines, dihydropyrimido-pyrimidines, pyridopyrimidines, naphthyridines, and pyridopyrazines of the general formula: 1 that inhibit cyclin-dependent kinase and tyrosine kinase enzymes, methods and intermediate compounds for their synthesis, as well as pharmaceutical compositions and methods for their use in treating, inhibiting or preventing maladies associated with cell proliferative disorders, including angiogenesis, atherosclerosis, restenosis, and cancer.

  本发明提供了抑制周期蛋白依赖性激酶和酪氨酸激酶酶的通用公式： 1 的苯基取代嘧啶嘧啶、二氢嘧啶嘧啶、嘧啶嘧啶、萘啶和嘧啶吡唑，以及用于合成它们的中间化合物、药物组合物和用于治疗、抑制或预防与细胞增殖紊乱相关的疾病，包括血管生成、动脉粥样硬化、再狭窄和癌症。
• PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS
  申请人：KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20210061810A1

  公开（公告）日：2021-03-04

  Disclosed are a compound selected from novel pyrimido[4,5-d]pyrimidin-2-one derivative compounds having excellent anti-proliferative activity against cancer cells, pharmaceutically acceptable salts thereof, hydrates thereof and stereoisomers thereof, a method for preparing the compound, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative diseases containing the compound as an active ingredient, and an anticancer composition against cancer cells, containing the compound as an active ingredient. The compounds of this invention exhibit most excellent selective inhibitory activity agaist LCK and anti-proliferative activity against cancer cells, thus being useful for inhibiting cancer cells, and for preventing or treating cancer metastasis and proliferative diseases.

  本发明涉及一种选择自新型嘧啶并[4,5-d]嘧啶-2-酮衍生物化合物的化合物，该化合物对癌细胞具有出色的抗增殖活性，其药学上可接受的盐、水合物和立体异构体，一种制备该化合物的方法，一种包含该化合物作为活性成分的用于预防、缓解或治疗癌转移和增殖性疾病的药物组合物，以及一种针对癌细胞的抗癌组合物，其中包含该化合物作为活性成分。本发明的化合物表现出对LCK的最优选择性抑制活性和对癌细胞的抗增殖活性，因此对于抑制癌细胞、预防或治疗癌转移和增殖性疾病非常有用。