(8S)-8-甲基-6,9-二氮杂螺[4.5]-7,10-二酮 | 90058-29-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (8S)-8-甲基-6,9-二氮杂螺[4.5]-7,10-二酮
• 英文名称: Alaptide
• 英文别名: (8S)-8-methyl-6,9-diazaspiro[4.5]decane-7,10-dione
• CAS: 90058-29-0
• 化学式: C₉H₁₄N₂O₂
• 分子量: 182.22
• InChiKey: LTRSPDHUDXWHRY-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  1--cyclopentan-carbonsaeure-(1)-methylester 以39的产率得到(8S)-8-甲基-6,9-二氮杂螺[4.5]-7,10-二酮
  参考文献：
  名称：

  GB2127807A

  摘要：

  公开号：

文献信息

• [EN] UTILIZATION OF ALAPTIDE AS TRANSDERMAL PENETRATION MODIFIER IN PHARMACEUTICAL COMPOSITIONS FOR HUMAN AND VETERINARY APPLICATIONS CONTAINING ANTI-INFLAMMATORY DRUGS AND/OR ANTIMICROBIAL CHEMOTHERAPEUTICS<br/>[FR] UTILISATION D'ALAPTIDE EN TANT QUE MODIFICATEUR DE PÉNÉTRATION TRANSDERMIQUE DANS DES COMPOSITIONS PHARMACEUTIQUES POUR DES APPLICATIONS HUMAINES ET VÉTÉRINAIRES CONTENANT DES MÉDICAMENTS ANTI-INFLAMMATOIRES ET/OU DES AGENTS CHIMIOTHÉRAPEUTIQUES ANTI
  申请人：UNIV VETERINARY AND PHARMACEUTICAL SCIENCES BRNO FACULTY OF PHARMACY

  公开号：WO2013020527A1

  公开（公告）日：2013-02-14

  The invention deals with the way of utilization of micronized, nanonized and/or surface-modified alaptide, which affects penetration of other pharmaceutically active compounds through the skin as a pharmaceutical adjuvant (excipient). These pharmaceutical compositions composed of alaptide as the excipient, pharmaceutical active ingredients (non-steroidal anti-inflammatory drugs and/or antipyretics/non-opiate analgesics and/or glucocorticoids and/or antimicrobial chemotherapeutics, i.e. antibacterials, antimycotics, antivirotics) and other pharmaceutical excipients can be used for preparation of drug formulations, which can influence the drug level in the body in time and can be used for both local and systemic administration.
• [EN] ALAPTIDE : METHODS OF EFFECTING ITS SOLUBILITY, MEMBRANE PERMEATION AND PHARMACEUTICAL COMPOSITIONS FOR HUMAN AND/OR VETERINARY APPLICATIONS<br/>[FR] ALAPTIDE : PROCÉDÉ DE SOLUBILISATION, ET DE MODIFICATION DE LA PERMÉATION MEMBRANAIRE, ET COMPOSITIONS PHARMACEUTIQUES POUR APPLICATIONS HUMAINES ET/OU VÉTÉRINAIRES
  申请人：UNIV VETERINARY AND PHARMACEUTICAL SCIENCES BRNO FACULTY OF PHARMACY

  公开号：WO2014019556A1

  公开（公告）日：2014-02-06

  The invention deals with the way of effecting the solubility of alaptide by the addition of low- molecular or high-molecular compounds or by generation of nanoparticles. These technological modifications of alaptide influence the penetration of alaptide through biological membranes, including skin. Alaptide modified in this way can be also used for preparation of pharmaceutical compositions (formulations), which can, in their turn, influence the absorption of alaptide.